The review highlights the issues of formation and development of the sanogenesis, the classification of sanogenetic mechanisms, theirs role in rehabilitation. The interpenetration of sanogenetic and pathogenetic mechanisms, participation of different tissues in the sanogenesis, including blood, is defined. It is showed the structure and significance of the erythron, formation of red blood cells, building border line of red blood cells, the significance of autofluorescence in the evaluation of sanogenetic reactions. The energetic importance of mitochondria, the receptor apparatus, various enzymes, transport proteins, electron transport chain in the metabolism that determines the degree of loss of sanogenetic potential and formation of preexisting diseases is defined. It is established the role of sanogenic reactions in the prevention of stress and post-stress recovery.
sanogenesis, pathogenesis, the erythron, formation of red blood cells, mitochondria, stress.
1. Problemy donozologicheskoy gigienicheskoy diagnostiki: Mat-ly nauch. konf. / Amosov I.S. [i dr.]. L.: AN SSSR, 1989. S. 229-231.
2. Gavril´chak I.N., Ignat´ev V.V., Kidalov V.N., Rymkevich P.P., Solov´ev V.N., Khadartsev A.A. O formoobrazovanii eritrotsitov v potoke krovi. Vestnik novykh meditsinskikh tekhnologiy. 2006. № 1. S. 6-9.
3. Kidalov V.N., Khadartsev A.A., Kulikova L.N., Molochko L.N., Ignat´ev V.V., Yakushina G.N., Karetnikov A.V. Garmoniya ritmov, dinamika i fraktal´nost´ krovi, kak proyavleniya sanogeneza: Monografiya / Pod red. A.A. Khadartseva - Tula: OOO RIF «INFRA» - Sankt- Peterburg, 2006. 172 s.
4. Es´kov V.M., Zilov V.G., Khadartsev A.A. Novye napravleniya v klinicheskoy kibernetike s pozitsiy teorii khaosa i sinergetiki. Sistemnyy analiz i upravlenie v biomeditsinskikh sistemakh. 2006. T. 5, № 3. S. 613-617.
5. Izbrannye tekhnologii diagnostiki: Monografiya / V.M. Es´kov [i dr.]; pod red. A.A. Khadartseva, V.G. Zilova, N.A. Fudina. Tula: OOO RIF «INFRA», 2008. 296 s.
6. Kartashova N.M., Kidalov V.N., Naumova E.M., Khadartsev A.A. Izmeneniya konfiguratsii i ul´trastruktury eritrotsitov v ekstremal´nykh dlya kletok usloviyakh. Vestnik novykh meditsinskikh tekhnologiy. 2005. № 1. S. 5-8.
7. Kidalov V.N., Muromtsev V.A., Yakushina G.N., Kulikov V.E. Izmenenie konfiguratsii i svecheniya eritrotsitov, vystraivayushchikh kraevuyu liniyu (VKL) pri vozdeystvii energo-informatsionnykh priborov i KVCh-izlucheniya na akupunkturnye tochki u bol´nykh khronicheskoy obstruktivnoy bolezn´yu legkikh. Mezhakademicheskiy informatsionnyy byulleten´. Mezhdunarodnaya akademiya. 2001. № 16. S. 82-84.
8. Kidalov V.N., Krayukhin A.S., Lushnov M.S., Syasin N.I., Khadartsev A.A., Yakushina G.N. Izmeneniya formy, ul´trastruktury i fluorestsentsii eritrotsitov perifiricheskoy krovi, transformiruyushchikhsya v poykilotsity. Vestnik novykh meditsinskikh tekhnologiy. 2005. № 3-4. S. 26-29.
9. Kidalov B.H., Lysak V.F. Kvantitativnaya eritrogramma i vozmozhnost´ ee ispol´zovaniya v klinike i eksperimente. Laboratornoe delo. 1989. V.8. S.36-40.
10. Kidalov V.N., Khadartsev A.A. Sanogenez i sanogennye reaktsii eritrona. Problemy meditsiny i obshchee predstavlenie o sanogeneze. Vestnik novykh meditsinskikh tekhnologiy. 2005. № 3-4. S. 5-9.
11. Kidalov V.N., Khadartsev A.A., Bagautdinov Sh.M., Chechetkin A.V. Postoyanstvo nepostoyannogo v teziogrammakh preparatov krovi (k standartizatsii issledovaniy kristallizatsii biologicheskikh zhidkostey). Vestnik novykh meditsinskikh tekhnologiy. 2008. №4. S. 7-13.
12. Kidalov V.N., Makarova N.V., Syasin N.I., Khadartsev AA. Autofluorestsentsiya nativnykh pokrovnykh tkaney i kletok krovi u bol´nykh KhOBL. Vestnik novykh meditsinskikh tekhnologiy. 2004. № 4. S. 9-14.
13. Kidalov V.N., Syasin N.I., Khadartsev A.A. K voprosu o fiziologicheskoy znachimosti izmeneniy formy, ul´trastruktury i fluorestsentsii eritrotsitov perifericheskoy krovi, transformiruyushchikhsya v ekhinotsity. Vestnik novykh meditsinskikh tekhnologiy. 2005. № 2. S. 6-10.
14. Kidalov V.N., Syasin N.I., Khadartsev A.A., Yakushina G.N. Znachenie estestvennoy fluorestsentsii (biolyuminestsentsii) elementov zhivogo organizma s pozitsii energoobmena. Vestnik novykh meditsinskikh tekhnologiy. 2002. № 2. S. 27-28.
15. Kidalov V.N., Khadartsev A A., Yakushina G.N. Teziograficheskie issledovaniya krovi i ikh prakticheskie vozmozhnosti. Vestnik novykh meditsinskikh tekhnologiy. 2004. № 1. S. 23-25.
16. Komarov F.I. Voprosy reaktivnosti organizma i funktsional´naya patologiya vnutrennikh organov. Issledovanie predboleznennykh sostoyaniy. Tallin: DKBF, 1973. S. 15-22.
17. Morozov V.N., Khadartsev A.A. K sovremennoy traktovke mekhanizmov stressa. Vestnik novykh meditsinskikh tekhnologiy. 2010. № 1. C. 15-17.
18. Es´kov V.M., Khadartsev A.A., Filatova O.E. Sinergetika v klinicheskoy kibernetike. Chast´ II. Osobennosti sanogeneza i patogeneza v usloviyakh Khanty-Mansiyskogo avtonomnogo okruga - Yugry: Monografiya - Samara: OOO «Ofort», 2007. 289 s.
19. Sistemnyy analiz, upravlenie i obrabotka informatsii v biologii i meditsine. Ch. VI. Sistemnyy analiz i sintez v izuchenii yavleniy sinergizma pri upravlenii gomeostazom organizma v usloviyakh sanogeneza i patogeneza: Monografiya / Pod red. V.M. Es´kova, A.A. Khadartseva-Samara - OOO «Ofort», 2005. 153 s.
20. Sistemnyy analiz, upravlenie i obrabotka informatsii v biologii i meditsine. Chast´ VII. Sinergeticheskiy kompartmentno-kpasternyy analiz i sintez dinamiki povedeniya vektora sostoyaniya organizma cheloveka na severe RF v usloviyakh sanogeneza i patogeneza / V.I. Adaykin, F.I. Ausheva, Yu.G. Burykin i dr.; Pod red. V.M. Es´kova i A.A. Khadartseva. Samara: OOO «Ofort», 2008. 159 s.
21. Skulachev V.P. Energetika biologicheskikh membran. M.: Nauka, 1989. 564 s.
22. Soroko E.M. Kriteriy garmonii samoorganizuyushchikhsya sotsioprirodnykh sistem. Vladivostok: DVO AN SSSR, 1989. 56 s.
23. Subbota A.G. Garmoniya i disgarmoniya v meditsine. Vyp. 1. SPb.: SPb NII skoroy pomoshchi im I.I. Dzhanelidze, 2002. S. 22-32.
24. Ushakov I.B. Kachestvo zhizni i zdorov´e cheloveka. M- Voronezh: Istoki, 2005. 130 s.
25. Khadartsev A.A. Biofizikokhimicheskie protsessy v upravlenii biologicheskimi sistemami. Vestnik novykh meditsinskikh tekhnologiy. 1999. N2. S. 34-37.
26. Teoriya i praktika vosstanovitel´noy meditsiny / Khadartsev A.A.[i dr.]. T.1. Tula-M.: RAMN. 2004. 248 s.
27. Khadartsev A.A., Morozov V.N., Karaseva Yu.V., Khadartseva K.A., Fudin N.A. Patofiziologiya stressa, kak balans stressogennykh i antistressovykh mekhanizmov. Vestnik nevrologii, psikhiatrii i neyrokhirurgii. 2012. № 7. S. 16-21.
28. Integrativnaya meditsina / Shabrov A.V. [i dr.]. SPB: SPbGMA im. I.I. Mechnikova i dr., 2004. 60 s.
29. Uncoupling protein 3 mediates H2O2 preconditioning-afforded cardioprotection through the inhibition of MPTP opening / Chen Y., Liu J. [et al.]. Cardiovasc Res. 2015 Feb 1. 105(2). P. 192-202. DOIhttps://doi.org/10.1093/cvr/cvu256. Epub 2014 Dec 16.
30. Eskov V.M., Khadartsev A.A., Eskov V.V., Filatova O.E. Quantitative Registration of the Degree of the Voluntariness and Involuntariness (of the Chaos) in Biomedical Systems. Journal of Analytical Sciences, Methods and Instrumentation (JASMI). June 2013. Vol. 3, № 2. PP. 67-74.
31. Interaction between overtraining and the interindividual variability may (not) trigger muscle oxidative stress and cardiomyocyte apoptosis in rats / Ferraresso RL, de Oliveira R [et al.]. Oxid Med Cell Longev. 2012. 2012. 935483. DOI:https://doi.org/10.1155/2012/935483. Epub 2012 Jul 15.
32. Lemeshko V.V. VDAC electronics: 2. A new, anaerobic mechanism of generation of the membrane potentials in mitochondria. Biochim Biophys Acta. 2014. 1838(7). P. 1801-1808. DOIhttps://doi.org/10.1016/j.bbamem.2014.02.007. Epub 2014 Feb 22.
33. J Mitochondrial biology, targets, and drug delivery / Milane L, Trivedi M, [et al.]// Control Release. 2015. 10. 207. P. 40-58. doi:https://doi.org/10.1016/j.jconrel.2015.03.036. Epub 2015 Apr 1.
34. Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemiareperfusion injury in heart / Nederlof R, Eerbeek O, [et al.]. Br J Pharmacol. 2014. 171(8). P. 2067-2079. DOI:https://doi.org/10.1111/bph.12363.
35. Modulation of mitochondrial respiratory function and ROS production by novel benzopyran analogues / Petruş A., Duicu O.M. [et al.]. Can J Physiol Pharmacol. 2015. 30. P. 1-8.
36. Setoyama D1, Fujimura Y, Miura D. Metabolomics reveals that carnitine palmitoyltransferase-1 is a novel target for oxidative inactivation in human cells. Genes to Cells (Impact Factor: 2.81). 10/2013; 18(12). DOI:https://doi.org/10.1111/gtc.12098
37. Veenman L, Gavish M. The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development. Pharmacol Ther. 2006. 110(3). P. 503-524. Epub 2005 Dec 7.
