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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Clinical Medicine and Pharmacology</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Clinical Medicine and Pharmacology</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Клиническая медицина и фармакология</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2409-3750</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">124435</article-id>
   <article-id pub-id-type="doi">10.12737/2409-3750-2026-12-1-2-7</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>Обзоры</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>reviews</subject>
    </subj-group>
    <subj-group>
     <subject>Обзоры</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">POSTOPERATIVE ANASTOMOSIS: STATUS OF THE PROBLEM AND PROSPECTS (literature review)</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ПОСЛЕОПЕРАЦИОННЫЕ АНАСТОМОЗИТЫ: СОСТОЯНИЕ ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ (обзор литературы)</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Казаков</surname>
       <given-names>М. С.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kazakov</surname>
       <given-names>M. S.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Гусейнов</surname>
       <given-names>Ариф Зиядович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Guseynov</surname>
       <given-names>Arif Ziyadovich</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Тульский государственный университет</institution>
    </aff>
    <aff>
     <institution xml:lang="en">Tula State University</institution>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Тульский государственный университет</institution>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Тульский государственный университет</institution>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2026-05-26T11:19:13+03:00">
    <day>26</day>
    <month>05</month>
    <year>2026</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-05-26T11:19:13+03:00">
    <day>26</day>
    <month>05</month>
    <year>2026</year>
   </pub-date>
   <volume>12</volume>
   <issue>1</issue>
   <fpage>2</fpage>
   <lpage>7</lpage>
   <history>
    <date date-type="received" iso-8601-date="2026-05-26T00:00:00+03:00">
     <day>26</day>
     <month>05</month>
     <year>2026</year>
    </date>
   </history>
   <self-uri xlink:href="https://zh-szf.ru/en/nauka/article/124435/view">https://zh-szf.ru/en/nauka/article/124435/view</self-uri>
   <abstract xml:lang="ru">
    <p>Анастомозиты представляют собой сложный патофизиологический каскад, объединяющий воспалительные реакции, повреждения тканей и глубокие нарушения процессов регенерации. В этиологии анастомозитов выделяют механические факторы, ишемию зоны анастомоза, инфекционные контаминации и модифицирующие факторы. Диагностика анастомозитов и формирующихся стриктур основывается на комплексном применении инструментальных и лабораторных методов. Эндоскопия (ЭГДС, колоноскопия) по праву считается «золотым стандартом» для прямой визуальной оценки состояния зоны анастомоза. Лечение анастомозитов представляет сложную проблему, носит комплексный характер и включает общее и местное лечение. Общая терапия направлена на поддержку жизненно важных функций, ликвидацию инфекции и обеспечение репарации тканей. Местная терапия включает непосредственное воздействие на зону анастомоза. Эндоскопическое лечение стало основой терапии послеоперационных анастомозитов и стриктур, предлагая малоинвазивные альтернативы реоперации. Баллонная дилатация остается методом выбора при относительно ранних стенозах.&#13;
Перспективным направлением является применение регенеративных агентов и тканевой инженерии. Профилактика анастомозитов включает совершенствование хирургической техники, применение экстрамукозных швов, предоперационный отбор и подготовку пациентов, соблюдение послеоперационных протоколов.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Anastomositis represents a complex pathophysiological cascade that combines inflammatory reactions, tissue damage, and profound impairments of regenerative processes. Mechanical factors, anastomotic ischemia, infectious contamination, and modifying factors are identified in the etiology of anastomositis.&#13;
Diagnosis of anastomositis and developing strictures is based on the integrated use of instrumental and laboratory methods. Endoscopy (EGD, colonoscopy) is rightfully considered the &quot;gold standard&quot; for direct visual assessment of the anastomotic area. Treatment of anastomositis is complex and comprehensive, involving both general and local treatment. General therapy is aimed at supporting vital functions, eliminating infection, and promoting tissue regeneration.&#13;
Local therapy involves direct interventions at the anastomotic area. Endoscopic treatment has become the mainstay of treatment for postoperative anastomositis and strictures, offering minimally invasive alternatives to reoperation. Balloon dilation remains the treatment of choice for relatively early stenoses.&#13;
A promising approach is the use of regenerative agents and tissue engineering. Prevention of anastomositis involves improving surgical technique, using extramucosal sutures, preoperative patient selection and preparation, and adherence to postoperative protocols.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>анастомозит</kwd>
    <kwd>диагностика</kwd>
    <kwd>общая терапия</kwd>
    <kwd>эндоскопическое лечение</kwd>
    <kwd>баллонная дилатация</kwd>
    <kwd>профилактика.</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>anastomosis</kwd>
    <kwd>diagnostics</kwd>
    <kwd>general therapy</kwd>
    <kwd>endoscopic treatment</kwd>
    <kwd>balloon dilation</kwd>
    <kwd>prevention.</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
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