Bulletin physiology and pathology of respiration Bulletin physiology and pathology of respiration Бюллетень физиологии и патологии дыхания 1998-5029 13119 10.12737/21463 ОБЗОРЫ REVIEWS ОБЗОРЫ MODERN CONCEPTS OF ESTROGENS ROLE AT PREGNANCY (REVIEW) СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О РОЛИ ЭСТРОГЕНОВ ВО ВРЕМЯ БЕРЕМЕННОСТИ (ОБЗОР ЛИТЕРАТУРЫ) Довжикова Инна Викторовна Dovzhikova Inna Viktorovna dov_kova100@rambler.ru

доктор биологических наук;

doctor of sciences in biology;

 Луценко Михаил Тимофеевич Lutsenko Mikhail Timofeevich lucenkomt@mail.ru

доктор медицинских наук;

doctor of medical sciences;

 Дальневосточный научный центр физиологии и патологии дыхания RU Far Eastern Scientific Center of Physiology and Pathology of Respiration RU 15 09 2016 15 09 2016 1 61 120 127 https://zh-szf.ru/en/nauka/article/13119/view

Цель статьи – проанализировать значение эстрогенов в период беременности. Кратко изложен механизм эффектов гормонов. Рассмотрено влияние эстрогенов на маточно-плацентарный кровоток, их необходимость для запуска программы морфогенеза тканей в плаценте и матке, влияние на выработку других стероидных и белковых гормонов, стимулирующее действие на работу 11β-гидроксистероиддегидрогеназы, регуляция экспрессии липопротеидов низкой плотности. Показаны факторы роста, служащие медиаторами эстрогенов. Представлен вывод, что в начале беременности эстрогены способствуют морфологическому и функциональному росту, развитию и дифференцировке плаценты, во второй половине беременности эстрогены стимулировали функциональное созревание. Кроме этого, гормоны играют важную роль в развитии легких, почек, печени, фолликулов яичника, костной ткани плода и способствуют формированию различных изменений в организме матери, необходимых для подержания беременности.

The article analyzes the importance of estrogen during pregnancy. The mechanism of hormones effects is summarized. The effect of estrogen on utero-placental blood flow, its necessity to run tissue morphogenesis in placenta and uterus, the impact on other steroid and protein hormones production, stimulating effect on 11β-hydroxysteroid dehydrogenase work, regulation of LDL expression are studied. The growth factors that are mediators of estrogen are shown. There was made a conclusion that in early pregnancy estrogens contribute to morphological and functional growth, development and differentiation of placenta and in the second half of pregnancy estrogens stimulate functional maturation. Furthermore, hormones play an important role in the development of lung, kidney, liver, ovarian follicles, fetal bone and promote the formation of different changes in the mother necessary for the maintenance of pregnancy.

 эстрогены механизм действия беременность. estrogens mechanism of action pregnancy

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