Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Habarovsk, Khabarovsk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
The contents of interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the blood serum were studied in 89 women in the first trimester of pregnancy. The first group (control) was made out of 25 women with uncomplicated pregnancy; the second had 23 women with the exacerbation of chronic simple bronchitis caused by parainfluenza of the 3rd type with antibody titer 1:16-1:64; the third one consisted of 21 patients with the exacerbation of chronic simple bronchitis induced by parainfluenza infection with antibody titers 1:32-1:128; the fourth group had 20 women with exacerbation of chronic simple bronchitis of parainfluenza etiology with antibody titer 1:64-1:256 at early stages of gestation. In the second group in comparison with the first one there were higher contents of IL-4: 21.1±2.00 pg/ml and INF-γ: 29.5±2.31 pg/ml than in the control group: 12.9±1.16 pg/ml (р<0.001) and 22.3±2.08 pg/ml (р<0.05), respectively. In the third group in comparison with the first one there were higher values of IL-4 (the growth by 132.6%, р<0.001), TNF-α (by 36%, p<0.01) and IFN-γ (by 43%, p<0.01). The patients in the fourth group in comparison with the third one did not have significant differences in TNF-α and IFN-γ. Buy there was the decrease of the level of IL-4 by 11.3% (р<0.05) that shows the imbalance of cytokines in women with exacerbation of chronic simple bronchitis caused by parainfluenza of the third type with antibody titer 1:64-1:256 at early stages of gestation. This may lead to persistent course of infectious-inflammatory process as well as to autoimmune damage of vital organs and the formation of initial placental insufficiency.
pregnancy, chronic bronchitis, parainfluenza virus type 3, antiviral antibodies titers, cytokines.
1. Avdeeva Zh.I., Alpatova N.A., Akol´zina S.E., Medunitsyn N.V. Immunoadjuvant effect of cytokines. Pacific medical journal 2009; 3:19−22 (in Russian).
2. Karpukhin G.I., editor. Influenza: the manual for doctors. St. Petersbug: Gippokrat; 2001 (in Russian).
3. Lobzin Yu.V., Mikhaylenko V.P., Lʹvov N.I. Droplet infection. St. Petersburg: Foliant; 2000 (in Russian).
4. Mikhaylova Yu.V. The clinical significance of cytokine profile and methods for medical correction in women with missed abortion: PhD thesis (Med. Sci.). Volgograd; 2007 (in Russian).
5. Nakhamchen L.G., Gorikov I.N., Kolosov V.P., Odireev A.N., Reznik V.I., Kolosov A.V. System inflammatory response at the exacerbation of chronic simple bronchitis caused by influenza virus A(H3N2) in women in the first trimester of pregnancy. Bûlleten´ fiziologii i patologii dyhaniâ 2016; 59:41-43 (in Russian).
6. Pavlenko V.I., Kolosov V.P., Naryshkina S.V. Features of comorbid flow, predicting and treatment of chronic obstructive pulmonary disease and coronary heart disease. Blagoveshchensk; 2014 (in Russian).
7. Paleev N.R., Paleev F.N. Cytokines and their role in pathogenesis of heart disease. Klinicheskaya meditsina 2004; 82(5):4-7 (in Russian)..
8. Ryazantseva N.V., Novitskii V.V., Belokon V.V., Zima A.P., Zhukova O.B., Nasledmkova I. О, Litvinova L. S, Kolobovnikova U.B., Chasovskih N.U. Cytokines and antiviral immuniy. Uspekhi fiziologicheskikh nauk 2006; 37(4):34-44 (in Russian).
9. Freydlin I.S., Nazarov P.G. Regulatory functions of pro-inflammatory cytokines and acute-phase proteins. Vestnik Rossiyskoy akademii meditsinskikh nauk 1999; 5:28-32 (in Russian).
10. Shipilov M.V., Ivanov V.V. Interferon-γ - the basis of antiviral protection in acute respiratory viral infections Uralskiy meditsinskiy zhurnal 2011; 7:72-75 (in Russian).
11. Yarilin A.A. Basics of immunology. Moscow: Meditsina; 1999 (in Russian).
12. Paludan S.R. Interleukin-4 and interferon-gamma: the quintessence of a mutual antagonistic relationship. Scand. J. Immunol. 1998; 48(5):459-468.
13. Paul W.E. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 1991; 77(9):1859-1870.
