Acta biomedica scientifica Acta biomedica scientifica Acta biomedica scientifica 2541-9420 2587-9596 14778 10.12737/23736 Клиническая медицина Clinical Medicine Клиническая медицина DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY ЗАВИСИМОСТЬ РЕЗУЛЬТАТА ЛАЗЕРНОГО ЛЕЧЕНИЯ ГИПЕРТРОФИЧЕСКИХ РУБЦОВ ОТ ИСХОДНОЙ РЕАКТИВНОСТИ ОРГАНИЗМА Кобец Максим Владимирович Kobets Maksim Владимирович kobetsmv@gmail.com Васильева Людмила Сергеевна Vasilyeva Lyudmila Сергеевна lsvirk@mail.ru 23 12 2016 23 12 2016 1 6 60 65 https://zh-szf.ru/en/nauka/article/14778/view

Цель – выявление взаимосвязи между реактивностью организма и результатом лечения гипертрофических рубцов. Установлено, что при положительном результате лечения у пациенток был ниже контрольного уровень СТГ (0,5±0,1мме/мл) и выше – уровни прогестерона (6,0±0,4нмоль/л) и ФСГ (6,7±0,5мме/мл); при отрицательном результате выше индекс атерогенности (2,6±0,2) и уровень СТГ (2,1±0,5), ниже – уровни кортизола (346,8±39нмоль/л), тестостерона (1,5±0,2мме/мл), IL-10 (3,89±1,6нг/мл) и антител к IFN-γ (0,206±0,05отн.ед.), IFN-α (0,385±0,02) и Fc-фрагментам (0,317±0,04)

The purpose of the study was to identify the relationship between the initial state of the organism and the result of the treatment of hypertrophic scars. 38women of 16–35years of age were examined on the 5–7th days of the menstrual cycle, 16 of them had normotrophic scars and 22 – hypertrophic scars. The quality of scars, lipid profile, the concen-tration of thyrotropin, free fraction of thyroxine, growth hormone (GH), luteinizing and follicle stimulating hormone (FSH), cortisol, prolactin, estradiol, testosterone, progesterone , the concentration of TNF-α, IL-4, IL-6, IL-10, and the level of autoantibodies to DNA, IFN-α , IFN-γ, b2-glycoprotein, Fc-fragments, collagen-2 were determined. Further on the laser treatment was performed: the scar surface was treated by multiple perforations under local anesthesia. Treatment outcome was assessed in 3months by the clinical characteristics of the scar. It was found that in 10women hypertrophic scars reformed in normotrophic scars after the treatment, and 12women still had hypertrophic scars. Patients with a positive result of treatment had a low concentration of GH (0.5±0.1) and high concentrations of proges-terone (6.0±0.4) and FSH (6.7±0.5 in the follicular phase of the cycle). The negative result of the treatment obtained in patients with significant shifts reactivity indicators: high atherogenic index (2.6±0.2) and the level of GH (2.1±0.5), low levels of cortisol (346.8±39), testosterone (1.5±0.2), IL-10 (3.89±1.6) and antibodies to IFN-γ (0.206±0.05), IFN-α (0.385±0.02), Fc-fragments (0.317±0.04).

 лечение гипертрофических рубцов реактивность организма патогенез гипертрофиче-ских рубцов treatment of hypertrophic scars reactivity pathogenesis of hypertrophic scars

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