The article presents data examination of children and male adolescents, aged 8 to 17years without eye pathologies, with primary hypertension diagnosis – established at the clinic of Scientific Centre for Family Health and Human Re-production Problems. Examination results were: 42patients (84eyes) had primary hypertension with optic disc drusen, 8patients (16eyes) had primary hypertension without optic disc drusen.Characteristics of basic functional changes of patients ophthalmic status with and without optic disc drusen on the basis of data of visometry refractometry, keratometry, computer perimetry, ultrasonic ehobiometry. Doppler angio-graphic examination of ocular vessels, electroretinography (ERG) according to registration standards proposed by the International Society of Clinical electrophysiology of (ISCEV), visual-evoked potentials (VEP), biomicroscopy of the eye, fundus photo registration.To verify and differentiate the prominence of the optic disc drusen in cases of the prominence of stagnant disc with characteristic extension of perineural space, all patients underwent an ultrasound scan procedure of the eyeball. The study obtained data on early pre-clinical manifestations of hypertensive angiohorioretinopaty.The risk factors for the formation of drusen of the optic nerve were identified. We determined that the presence of drusen does not lead to the aggravation of the changes of the visual system, formed under the influence of high blood pressure, affecting only the indicators characterizing ischemic processes in the retina and the optic nerve, which is due to the influence of compression of drusen on glial tissue and the vascular wall.
children, essential arterial hypertension, drusen of the optic disc
1. BogolyubskayaAY (2007). Assessment of the state of the target organs in hypertensive patients [Otsenka sostoyaniya organov-misheney u bol’nykh arterial’noy gipertoniey]. Pediatriya, (2), 17-21
2. VolkovaNV, ShchukoAG, MalyshevVV (2010). Retrospective analysis of risk factors for the development of scar changes of outflow pathways of intraocular fluid after fistulizing antiglaucomatous surgery. Report1 [Retrospektivnyy analiz faktorov riska razvitiya rubtsovykh izmeneniy putey ottoka vnutriglaznoy zhidkosti posle fistuliziruyushchikh antiglaukomatoznykh operatsiy. Soobshchenie 1]. Natsional’nyy zhurnal Glaukoma, (3), 35-40.
3. VolkovaNV, ShchukoAG, YurevaTN, MalyshevVV(2006). Risk factors of inadequate formation of the outflow pathways after penetrating deep sclerectomy [Faktory riska neadekvatnogo formirovaniya putey ottoka posle nepronikayushchey glubokoy sklerektomii]. Sibirskiy meditsinskiy zhurnal, 7(65), 17-19.
4. KislyakOA (2007). Hypertension in adolescence [Arterial’naya gipertenziya v podrostkovom vozraste], 288.
5. KislyakOA (2003). Risk factors for cardiovascular disease in adolescents with hypertension [Faktory riska serdechno-sosudistykh zabolevaniy u podrostkov s arterial’noy gipertenziey]. Pediatriya, (2), 16-20.
6. .KolesnikovaLI (2010). Diagnosis, treatment, principles of prevention of hypertension in children and adolescents [Diagnostika, lechenie, printsipy profilaktiki arterial’noy gipertenzii u detey i podrostkov: metodicheskie rekomendatsii], 6.
7. KorolenkoAV, OliferovskayaNV, SavinaYN, Mikha-levichIM, MalyshevVV (201). Laser pleoptic and binarim-eter in the treatment of amblyopia in children of different ages [Lazerpleoptika i binarimetriya v lechenii ambliopii u detey raznogo vozrasta]. Kubanskiy nauchnyy meditsinskiy vestnik, (1), 61-65.
8. KorolenkoAV, SavinaYN, ShchukoAG (2013). Changes in regional blood flow in children with amblyopia [Izmeneniya regionarnogo krovoobrashcheniya u detey pri ambliopii]. Fedorovskie chteniya-2013: Sbornik tezisov XI Vserossiyskoy nauchno-prakticheskoy konferentsii, 260.
9. KorolenkoAV, SavinaYN, ShchukoAG, OliferovskayaNV, PutintsevaNP (2012). The study of regional circulation in the strabismic amblyopia [Issledovanie regionarnogo krovoobrashcheniya pri disbinokulyarnoy ambliopii]. Vestnik Novosibirskogo gosudarstvennogo universiteta. Seriya Biologiya, klinicheskaya meditsina, 10(5), 117-122.
10. LeontievaIV (2010). Damage of target organs in children and adolescents with hypertension [Porazhenie organov-misheney u detey i podrostkov s arterial’noy gipertenziey]. Rossiyskiy vestnik perinatologii i pediatrii, 55(2), 30-41
11. RozanovVB (2006). Prognostic value of blood pressure in adolescence (22-year prospective follow-up) [Prognosticheskoe znachenie arterial’nogo davleniya v podrostkovom vozraste (22-letnee prospektivnoe nablyudenie)]. Rossiyskiy vestnik perinatologii i pediatrii, (5), 27-41
12. SavinaYN, ZhukovaSI, ShchukoAG, YurevaTN (2013). Ophthalmic manifestations of essential hyper-tension in children and adolescents [Oftal’mologicheskie proyavleniya essentsial’noy arterial’noy gipertenzii u detey i podrostkov (Predvaritel’noe soobshchenie)]. Vestnik Orenburgskogo gosudarstvennogo universiteta, (4), 117-220.
13. ShchukoAG, ZhukovaSI, YurevaTN (2013). Ultrasound diagnosis in ophthalmology [Ul’trazvukovaya diagnostika v oftal’mologii], 129.
14. ShchukoAG, SavinaYN, ZhukovaSI, YurevaTI,DolgikhVV (2013). The role of highly informative methods in the diagnostics of early changes of the visual system in adolescents with essential hypertension [Rol’ vysokoinformativnykh metodov issledovaniya v diagnostike rannikh izmeneniy zritel’noy sistemy u podrostkov s essentsial’noy arterial’noy gipertenziey]. Aktual’nye voprosy sovremennoy oftal’mologii: Sbornik Yubileynoy Vserossiyskoy nauchno-prakticheskoy konferentsii, 218-221.
15. YariginNE, SerovVV (1977). Atlas of pathologic histology [Atlas patologicheskoy gistologii], 20
16. GrippoTM, RogersSW, TsaiJC (2012). Optic disc drusen. Glaucoma Today, (2), 19-24.
17. KenyonGT, MooreB, JeffsJ, DenningKS,StephensGJ, TravisBJ, GeorgeJS, TheilerJ, MarshakDW (2003). A model of high-frequency oscillatory potentials in retinal ganglion cells. Vis. Neurosci., 20(5), 465-480.
18. MarmorMF, HolderGE, SeeligerMW, YamamotoS (2004). Standard for clinical electroretinography. Documenta Ophthalmologica, (108), 107-114.
19. Optic Nerve Head Drusen (2001). Handbook of ocular disease management. Available at: http://en.academic.ru/dic.nsf/enwiki/4727562 (1.10.2014).
20. RubinsteinK, AliM (1982). Retinal complications of optic disc drusen. Br. J Ophthalmol., 66(2), 83-95.
21. SandersTE, GayAJ, NewmanM (1970). Drüsen of the optic disk-hemorrhagic complications. Trans. Am. Ophthalmol. Soc., (68), 186-218.
22. SpencerWH (1978). XXXIV Edward Jackson Memorial Lecture: drusen of the optic disc and aberrant axoplasmic transport. Ophthalmology, 85(1), 21-38.
23. TsoMO (1981). Pathology and pathogenesis of drusen of the optic nerve head. Ophthalmology, 88(10), 1066-1080
24. WilkinsJM, PomeranzHD (2004). Visual manifestations of visible and buried optic disc drusen. J.Neuroophthalmol., 24(2), 125-129.
