Tomsk, Tomsk, Russian Federation
Tomsk, Tomsk, Russian Federation
Tomsk, Tomsk, Russian Federation
Krasnoyarsk V.F. Voino‐Yasenetsky State Medical University (kafedra biologicheskoy himii s kursami medicinskoy, farmacevticheskoy i toksikologicheskoy himii, professor)
Krasnoyarsk, Krasnoyarsk, Russian Federation
Ocenivali rol' karbonilirovaniya belkov v molekulyarnyh mehanizmah regulyacii proliferacii opuholevyh kletok linii MSF-7 pri deystvii roskovitina – selektinogo ingibitora ciklinzavisimyh kinaz. Roskovitin privodil k snizheniyu redoks-potenciala sistemy glutationa, uvelicheniyu karbonil'nyh proizvodnyh belkov i sposobstvoval ostanovke kletochnogo cikla v G0/G1 i G2/M fazah za schet vzaimodeystviya s ciklin-zavisimymi kinazami, a takzhe mog sposobstvovat' karbonilirovaniyu ferentov.
karbonil'nye proizvodnye belkov, proliferaciya, okislitel'nyy stress, redoks-status, adenokarcinoma molochnoy zhelezy
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