Acta biomedica scientifica Acta biomedica scientifica Acta biomedica scientifica 2541-9420 2587-9596 16549 10.12737/article_590823a5489433.14864804 обзоры Review обзоры RESULTS OF THE STUDY OF THE PATHOPHYSIOLOGICAL EFFECTS OF DYSREGULATION OF FREE-RADICAL PROCESSES: DEADLOCK OR A NEW IMPULSE? ИТОГИ ИЗУЧЕНИЯ ПАТОФИЗИОЛОГИЧЕСКИХ ПОСЛЕДСТВИЙ НАРУШЕНИЯ РЕГУЛЯЦИИ СВОБОДНОРАДИКАЛЬНЫХ ПРОЦЕССОВ: ТУПИК ИЛИ НОВЫЙ ИМПУЛЬС? Ланкин Вадим Зиновьевич Lankin Vadim Zinovievich lankin@cardio.ru

доктор биологических наук;

doctor of sciences in biology;

 Тихазе Алла Карловна Tikhaze Alla Karlovna tikhaze@cardio.ru

доктор медицинских наук;

doctor of medical sciences;

 Национальный медицинский исследовательский центр кардиологии имени академика Е.И. Чазова Москва Россия E.I. Chazov National Medical Research Centre of Cardiology Moscow Russian Federation Институт клинической кардиологии Москва Россия Institute of Clinical Cardiology Moscow Russian Federation 1 3 160 167 https://zh-szf.ru/en/nauka/article/16549/view

В обзоре приводятся результаты многолетних работ авторов и данные зарубежных исследований, свидетельствующие о важной роли свободнорадикальных процессов в этиологии и патогенезе атеросклероза. Высказана гипотеза о том, что существует единый молекулярный механизм первичных предатерогенных повреждений стенки сосудов при атеросклерозе и диабете, который состоит в усиленном образовании карбонил-модифицированных липопротеидов низкой плотности, накапливающихся в пенистых клетках.

В обзоре приводятся результаты многолетних работ авторов и данные зарубежных исследований, свидетельствующие о важной роли свободнорадикальных процессов в этиологии и патогенезе атеросклероза. Высказана гипотеза о том, что существует единый молекулярный механизм первичных предатерогенных повреждений стенки сосудов при атеросклерозе и диабете, который состоит в усиленном образовании карбонил-модифицированных липопротеидов низкой плотности, накапливающихся в пенистых клетках.

 свободные радикалы модифицированные липопротеиды низкой плотности окислительный стресс карбонильный стресс атеросклероз сахарный диабет

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