THE CORRELATION OF THE 48BP VNTR LOCUS OF DRN4 GENE WITH OVERWEIGHT / OBESITY (LITERATURE REVIEW)
Rubrics: GENETICS, PROTEOMICS & METABOLOMICS
Authors:
1.
Irkutsk, Irkutsk region, Russian Federation
2.
Scientific Centre for Family Health and Human Reproduction Problems
(laboratoriya personalizirovannoy mediciny, rukovoditel')
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(direktor)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 63
to 68
Status:
Published
Received:
19.10.2017
Accepted:
22.11.2017
Published:
22.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
izbytochnaya massa tela, ozhirenie, dofamin, receptory dofamina 2 tipa, DRD4, lokus VNTR, sistema podkrepleniya, narusheniya pischevogo povedeniya
Abstract (English):
Rasprostranennost' izbytochnogo vesa i ozhireniya v sovremennom mire imeet obschemirovoy masshtab. Po dannym Vsemirnoy organizacii zdravoohraneniya (2014) v mire okolo 2 milliardov vzroslyh imeyut izbytochnyy ves. V vozraste do 5 let izbytochnoy massoy tela ili ozhireniem stradayut 42 milliona detey. Predstavlen vzglyad na ozhirenie kak bihevioral'noe zabolevanie, voznikayuschee vsledstvie narusheniy v funkcionirovanii genov receptorov dofaminergicheskoy sistemy 2 tipa, a imenno – gena DRD4. Proveden analiz literaturnyh dannyh, posvyaschennyh poisku vzaimosvyazi polimorfnogo varianta gena DRD4 s narusheniyami pischevogo povedeniya, izbytochnoy massoy tela i ozhireniem. Naibol'shiy interes predstavlyaet tandemnyy povtor 48bp VNTR. Dannye literatury po poisku vzaimosvyazi 48bp VNTR polimorfizma s izbytochnoy massoy tela, ozhireniem i narusheniem pischevogo povedeniya krayne protivorechivy: v populyacii vzroslogo naseleniya Pol'shi, Shvecii, Kanady, SShA, a takzhe v detskoy populyacii Kanady ustanovlena polozhitel'naya svyaz' mezhdu nositel'stvom dlinnoy 7R-alleli i indeksom massy tela, ozhireniem, narusheniyami pischevogo povedeniya. Odnako issledovaniya, provedennye v SShA, Brazilii, ne vyyaviv ukazannoy svyazi, pokazali znachimost' drugih, v tom chisle korotkih alleley, tandemnogo povtora VNTR. Tret'ya gruppa issledovateley ne obnaruzhila dostovernyh svyazey ni dlya dlinnoy, ni dlya korotkoy alleley VNTR polimorfizma DRD4 v populyaciyah Germanii, Turcii i Ispanii. Takim obrazom, v stat'e predstavlen obzor literatury, prizvannyy obobschit' vzaimosvyaz' mezhdu tandemnym povtorom 48bp VNTR gena DRD4 i izbytochnym vesom, ozhireniem i narusheniem povedeniya, udelyaya pri etom osoboe vnimanie na razlichiya v metodologii i rezul'tatah issledovaniya.
Rasprostranennost' izbytochnogo vesa i ozhireniya v sovremennom mire imeet obschemirovoy masshtab. Po dannym Vsemirnoy organizacii zdravoohraneniya (2014) v mire okolo 2 milliardov vzroslyh imeyut izbytochnyy ves. V vozraste do 5 let izbytochnoy massoy tela ili ozhireniem stradayut 42 milliona detey. Predstavlen vzglyad na ozhirenie kak bihevioral'noe zabolevanie, voznikayuschee vsledstvie narusheniy v funkcionirovanii genov receptorov dofaminergicheskoy sistemy 2 tipa, a imenno – gena DRD4. Proveden analiz literaturnyh dannyh, posvyaschennyh poisku vzaimosvyazi polimorfnogo varianta gena DRD4 s narusheniyami pischevogo povedeniya, izbytochnoy massoy tela i ozhireniem. Naibol'shiy interes predstavlyaet tandemnyy povtor 48bp VNTR. Dannye literatury po poisku vzaimosvyazi 48bp VNTR polimorfizma s izbytochnoy massoy tela, ozhireniem i narusheniem pischevogo povedeniya krayne protivorechivy: v populyacii vzroslogo naseleniya Pol'shi, Shvecii, Kanady, SShA, a takzhe v detskoy populyacii Kanady ustanovlena polozhitel'naya svyaz' mezhdu nositel'stvom dlinnoy 7R-alleli i indeksom massy tela, ozhireniem, narusheniyami pischevogo povedeniya. Odnako issledovaniya, provedennye v SShA, Brazilii, ne vyyaviv ukazannoy svyazi, pokazali znachimost' drugih, v tom chisle korotkih alleley, tandemnogo povtora VNTR. Tret'ya gruppa issledovateley ne obnaruzhila dostovernyh svyazey ni dlya dlinnoy, ni dlya korotkoy alleley VNTR polimorfizma DRD4 v populyaciyah Germanii, Turcii i Ispanii. Takim obrazom, v stat'e predstavlen obzor literatury, prizvannyy obobschit' vzaimosvyaz' mezhdu tandemnym povtorom 48bp VNTR gena DRD4 i izbytochnym vesom, ozhireniem i narusheniem povedeniya, udelyaya pri etom osoboe vnimanie na razlichiya v metodologii i rezul'tatah issledovaniya.
Keywords:
izbytochnaya massa tela, ozhirenie, dofamin, receptory dofamina 2 tipa, DRD4, lokus VNTR, sistema podkrepleniya, narusheniya pischevogo povedeniya
izbytochnaya massa tela, ozhirenie, dofamin, receptory dofamina 2 tipa, DRD4, lokus VNTR, sistema podkrepleniya, narusheniya pischevogo povedeniya
1. Spislit svyaz' tandemnogo
