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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Clinical Medicine and Pharmacology</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Clinical Medicine and Pharmacology</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Клиническая медицина и фармакология</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2409-3750</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">19991</article-id>
   <article-id pub-id-type="doi">10.12737/article_5a72e5f69abd12.30490466</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>Актуальные вопросы фармакотерапии</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>topical issues of pharmacotherapy</subject>
    </subj-group>
    <subj-group>
     <subject>Актуальные вопросы фармакотерапии</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">EVOLUTION OF METHODS OF INTRODUCTION OF PHARMACOLOGICAL  PREPARATIONS</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ЭВОЛЮЦИЯ СПОСОБОВ ВВЕДЕНИЯ   ФАРМАКОЛОГИЧЕСКИХ ПРЕПАРАТОВ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Заволко</surname>
       <given-names>М. С.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Zavolko</surname>
       <given-names>M. S.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Никифоров</surname>
       <given-names>А. В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Nikiforov</surname>
       <given-names>A. V.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Токарев</surname>
       <given-names>А. Р.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Tokarev</surname>
       <given-names>A. R.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Киреев</surname>
       <given-names>Семен Семенович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kireev</surname>
       <given-names>Semen Semenovich</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Наумов</surname>
       <given-names>А. В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Naumov</surname>
       <given-names>A. V.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-5"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Елисеенков</surname>
       <given-names>О. Н.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Eliseenkov</surname>
       <given-names>O. N.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-6"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Шелухина</surname>
       <given-names>Н. В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Sheluhina</surname>
       <given-names>N. V.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-7"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Никифорова</surname>
       <given-names>Е В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Nikiforova</surname>
       <given-names>E V.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-8"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Тульский государственный университет</institution>
     <city>Тула</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Тульский государственный университет</institution>
     <city>Тула</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Тульский государственный университет</institution>
     <city>Тула</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Тульский государственный университет</institution>
     <city>Тула</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Тульский государственный университет</institution>
     <city>Тула</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Тульский государственный университет</institution>
     <city>Тула</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">Тульский государственный университет</institution>
     <city>Тула</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Тульский государственный университет</institution>
     <city>Тула</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-5">
    <aff>
     <institution xml:lang="ru">ГУЗ Тульская городская клиническая больница скорой медицинской помощи им. Д.Я. Ваныкина</institution>
     <city>Тула</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГУЗ Тульская городская клиническая больница скорой медицинской помощи им. Д.Я. Ваныкина</institution>
     <city>Тула</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-6">
    <aff>
     <institution xml:lang="ru">ГУЗ Тульская городская клиническая больница скорой медицинской помощи им. Д.Я. Ваныкина</institution>
     <city>Тула</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГУЗ Тульская городская клиническая больница скорой медицинской помощи им. Д.Я. Ваныкина</institution>
     <city>Тула</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-7">
    <aff>
     <institution xml:lang="ru">ГУЗ Тульская городская клиническая больница скорой медицинской помощи им. Д.Я. Ваныкина</institution>
     <city>Тула</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГУЗ Тульская городская клиническая больница скорой медицинской помощи им. Д.Я. Ваныкина</institution>
     <city>Тула</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-8">
    <aff>
     <institution xml:lang="ru">ГУЗ Тульская городская клиническая больница скорой медицинской помощи им. Д.Я. Ваныкина</institution>
     <city>Тула</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГУЗ Тульская городская клиническая больница скорой медицинской помощи им. Д.Я. Ваныкина</institution>
     <city>Тула</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <volume>3</volume>
   <issue>4</issue>
   <fpage>54</fpage>
   <lpage>58</lpage>
   <self-uri xlink:href="https://zh-szf.ru/en/nauka/article/19991/view">https://zh-szf.ru/en/nauka/article/19991/view</self-uri>
   <abstract xml:lang="ru">
    <p>В статье проведен обзор литературы по оптимизации путей введения лекарственных средств. Про-&#13;
веден анализ основных действующих способов доставки фармакологических препаратов с описанием их &#13;
преимуществ и недостатков. Более широко освещен ингаляционный путь введения, как наиболее современный и перспективный.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>В статье проведен обзор литературы по оптимизации путей введения лекарственных средств. Про-&#13;
веден анализ основных действующих способов доставки фармакологических препаратов с описанием их &#13;
преимуществ и недостатков. Более широко освещен ингаляционный путь введения, как наиболее современный и перспективный.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>способы доставки лекарственных средств</kwd>
    <kwd>ингаляционный путь введения</kwd>
    <kwd>современный способ доставки лекарств</kwd>
    <kwd>анестезиология</kwd>
    <kwd>премедикация</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chong CR, Sullivan D J. New uses for old drugs. Nature 2007; 448: 645-646</mixed-citation>
     <mixed-citation xml:lang="en">Chong CR, Sullivan D J. New uses for old drugs. Nature 2007; 448: 645-646</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Benni JM, Patil PA. J Basic Clin Physiol Pharmacol. Non-diabetic clinical applications of insulin.2016 Sep 1;27(5):445-56.</mixed-citation>
     <mixed-citation xml:lang="en">Benni JM, Patil PA. J Basic Clin Physiol Pharmacol. Non-diabetic clinical applications of insulin.2016 Sep 1;27(5):445-56.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">She P, Wang Y, Luo Z, Chen L, Tan R, Wang Y, Wu Y. Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa. Microbiologyopen. 2017 Nov 27.</mixed-citation>
     <mixed-citation xml:lang="en">She P, Wang Y, Luo Z, Chen L, Tan R, Wang Y, Wu Y. Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa. Microbiologyopen. 2017 Nov 27.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">World Health Organization. Development of Paediatric Medicines: Points to Consider in Formulation. Geneva, Switzerland: World Health Organization; 2012. WHO Technical Report Series, No. 970, Annex 5</mixed-citation>
     <mixed-citation xml:lang="en">World Health Organization. Development of Paediatric Medicines: Points to Consider in Formulation. Geneva, Switzerland: World Health Organization; 2012. WHO Technical Report Series, No. 970, Annex 5</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">European Medicines Agency. Guideline on pharmaceutical development of medicines for paediatric use. EMA/CHMP/QWP/805880/2012 Rev. 2</mixed-citation>
     <mixed-citation xml:lang="en">European Medicines Agency. Guideline on pharmaceutical development of medicines for paediatric use. EMA/CHMP/QWP/805880/2012 Rev. 2</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Бертрам Г.Кацунг Базисная и клиническая фармакология в 2х томах, 2 издание М:Бином 2007: том 1, 75</mixed-citation>
     <mixed-citation xml:lang="en">Bertram G.Kacung Bazisnaya i klinicheskaya farmakologiya v 2h tomah, 2 izdanie M:Binom 2007: tom 1, 75</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Avinash Y Kaushik, Ajay K Tiwari, and Ajay Gaur Role of excipients and polymeric advancements in preparation of floating drug delivery systems Int J Pharm Investig. 2015 Jan-Mar; 5(1): 1-12.</mixed-citation>
     <mixed-citation xml:lang="en">Avinash Y Kaushik, Ajay K Tiwari, and Ajay Gaur Role of excipients and polymeric advancements in preparation of floating drug delivery systems Int J Pharm Investig. 2015 Jan-Mar; 5(1): 1-12.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Back DJ1, Rogers SM Review: first-pass metabolism by the gastrointestinal mucosa.  Aliment Pharmacol Ther. 1987 Oct;1(5):339-57</mixed-citation>
     <mixed-citation xml:lang="en">Back DJ1, Rogers SM Review: first-pass metabolism by the gastrointestinal mucosa.  Aliment Pharmacol Ther. 1987 Oct;1(5):339-57</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Breitkreutz J, Wessel T, Boos J. 13. Dosage forms for oral drug administration. In: Choonara I, Nunn T, Kearns G, eds. Introduction to Paediatric and Perinatal Drug Therapy. Nottingham, UK: Nottingham University Press;2003:189-205</mixed-citation>
     <mixed-citation xml:lang="en">Breitkreutz J, Wessel T, Boos J. 13. Dosage forms for oral drug administration. In: Choonara I, Nunn T, Kearns G, eds. Introduction to Paediatric and Perinatal Drug Therapy. Nottingham, UK: Nottingham University Press;2003:189-205</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Marconati M, Raut S, Burbidge A, Engmann J, Ramaioli M An in vitro experiment to simulate how easy tablets are to swallow. Int J Pharm. 2017 Oct 18;535(1-2):27-37</mixed-citation>
     <mixed-citation xml:lang="en">Marconati M, Raut S, Burbidge A, Engmann J, Ramaioli M An in vitro experiment to simulate how easy tablets are to swallow. Int J Pharm. 2017 Oct 18;535(1-2):27-37</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Rudralingam M, Randall C, Mighell AJ The use of topical steroid preparations in oral medicine in the UK Br Dent J. 2017 Dec;223(9):633-638</mixed-citation>
     <mixed-citation xml:lang="en">Rudralingam M, Randall C, Mighell AJ The use of topical steroid preparations in oral medicine in the UK Br Dent J. 2017 Dec;223(9):633-638</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">van Hoogdalem E, de Boer AG, Breimer DD Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs. Clin Pharmacokinet. 1991 Jul;21(1):11-26.</mixed-citation>
     <mixed-citation xml:lang="en">van Hoogdalem E, de Boer AG, Breimer DD Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs. Clin Pharmacokinet. 1991 Jul;21(1):11-26.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Netter FH, Hansen JT,  Atlas Human of Anatomy 3rd edition 2003: 300-303</mixed-citation>
     <mixed-citation xml:lang="en">Netter FH, Hansen JT,  Atlas Human of Anatomy 3rd edition 2003: 300-303</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">de Boer AG, Moolenaar F, de Leede LG, Breimer DD Rectal drug administration: clinical pharmacokinetic considerations Clin Pharmacokinet. 1982 Jul-Aug;7(4):285-311</mixed-citation>
     <mixed-citation xml:lang="en">de Boer AG, Moolenaar F, de Leede LG, Breimer DD Rectal drug administration: clinical pharmacokinetic considerations Clin Pharmacokinet. 1982 Jul-Aug;7(4):285-311</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Quintana DS, Alvares GA, Hickie IB, Guastella AJ. Neurosci Biobehav Rev Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model. 2015; 49: 182-192.</mixed-citation>
     <mixed-citation xml:lang="en">Quintana DS, Alvares GA, Hickie IB, Guastella AJ. Neurosci Biobehav Rev Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model. 2015; 49: 182-192.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Thorne RG, Pronk GJ, Padmanabhan V, Frey WH II. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 2004; 127: 481-496.</mixed-citation>
     <mixed-citation xml:lang="en">Thorne RG, Pronk GJ, Padmanabhan V, Frey WH II. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 2004; 127: 481-496.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yamamoto A, Iseki T, Ochi-Sugiyama M, Okada N, Fujita T, Muranishi S. Absorption of water-soluble compounds with different molecular weights and [Asu1.7]-eel calcitonin from various mucosal administration sites.  J Control Release 2001; 76: 363-374.</mixed-citation>
     <mixed-citation xml:lang="en">Yamamoto A, Iseki T, Ochi-Sugiyama M, Okada N, Fujita T, Muranishi S. Absorption of water-soluble compounds with different molecular weights and [Asu1.7]-eel calcitonin from various mucosal administration sites.  J Control Release 2001; 76: 363-374.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Guastella AJ, Hickie IB, McGuinness MM, Otis M, Woods EA, Disinger HM et al Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research  . Psychoneuroendocrinology 2013; 38: 612-625.</mixed-citation>
     <mixed-citation xml:lang="en">Guastella AJ, Hickie IB, McGuinness MM, Otis M, Woods EA, Disinger HM et al Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research  . Psychoneuroendocrinology 2013; 38: 612-625.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Miller JL, Ashford JW, Archer SM, Rudy AC, Wermeling DP.  Comparison of intranasal administration of haloperidol with intravenous and intramuscular administration: a pilot pharmacokinetic study. Pharmacotherapy 2008; 28: 875-882.</mixed-citation>
     <mixed-citation xml:lang="en">Miller JL, Ashford JW, Archer SM, Rudy AC, Wermeling DP.  Comparison of intranasal administration of haloperidol with intravenous and intramuscular administration: a pilot pharmacokinetic study. Pharmacotherapy 2008; 28: 875-882.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Misra A, Ganesh S, Shahiwala A, Shah SP. Drug delivery to the central nervous system: a review. J Pharm Pharm Sci. 2003 May-Aug;6(2):252-73.</mixed-citation>
     <mixed-citation xml:lang="en">Misra A, Ganesh S, Shahiwala A, Shah SP. Drug delivery to the central nervous system: a review. J Pharm Pharm Sci. 2003 May-Aug;6(2):252-73.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Rosenbaum SE, Basic pharmacokinetics and pharmacodynamics, 2nd Edition. Hoboken, New Jersey : John Wiley &amp; Sons, Inc., 2017.</mixed-citation>
     <mixed-citation xml:lang="en">Rosenbaum SE, Basic pharmacokinetics and pharmacodynamics, 2nd Edition. Hoboken, New Jersey : John Wiley &amp; Sons, Inc., 2017.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Gradon L., Sosnowski T.R. Formation of particles for dry powder inhalers. Advanced Powder Technology Volume 25, Issue 1, January 2014: 43-55.</mixed-citation>
     <mixed-citation xml:lang="en">Gradon L., Sosnowski T.R. Formation of particles for dry powder inhalers. Advanced Powder Technology Volume 25, Issue 1, January 2014: 43-55.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Tuncer DI, Nevin C. Controlled Delivery of Peptides and Proteins. Curr Pharm Des. 2007;13:99-117</mixed-citation>
     <mixed-citation xml:lang="en">Tuncer DI, Nevin C. Controlled Delivery of Peptides and Proteins. Curr Pharm Des. 2007;13:99-117</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B24">
    <label>24.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ma JKH, Bhat M, Rojanasakul Y Drug metabolism and enzyme kinetics in the lung. In: Lenfant C, editor. Inhalation aerosols. Physical and biological basis for therapy. New York: Marcel Dekker Inc.; 1996. pp. 155-195. 94.</mixed-citation>
     <mixed-citation xml:lang="en">Ma JKH, Bhat M, Rojanasakul Y Drug metabolism and enzyme kinetics in the lung. In: Lenfant C, editor. Inhalation aerosols. Physical and biological basis for therapy. New York: Marcel Dekker Inc.; 1996. pp. 155-195. 94.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B25">
    <label>25.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Сапин М.Р., Бочаров В.Я., Никитюк Д.Б., Сатюкова Г.С., Селин Ю.М., Спирин Б.А. Анатомия человека в 2х томах, 5 изд., М.Медицина 2001: том 2, 221-226</mixed-citation>
     <mixed-citation xml:lang="en">Sapin M.R., Bocharov V.Ya., Nikityuk D.B., Satyukova G.S., Selin Yu.M., Spirin B.A. Anatomiya cheloveka v 2h tomah, 5 izd., M.Medicina 2001: tom 2, 221-226</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B26">
    <label>26.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Patton JS Mechanisms of macromolecule absorption by the lungs. Advanced Drug Delivery Rev. 1996;19:3-36.</mixed-citation>
     <mixed-citation xml:lang="en">Patton JS Mechanisms of macromolecule absorption by the lungs. Advanced Drug Delivery Rev. 1996;19:3-36.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B27">
    <label>27.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Smaldone GC, Perry RJ, Bennett WD, Messina MS, Zwang J, Ilowite J. Interpretation of ‘24 hour lung retention’ in studies of mucociliary clearance. J Aerosol Med. 1988;1:11-20.</mixed-citation>
     <mixed-citation xml:lang="en">Smaldone GC, Perry RJ, Bennett WD, Messina MS, Zwang J, Ilowite J. Interpretation of ‘24 hour lung retention’ in studies of mucociliary clearance. J Aerosol Med. 1988;1:11-20.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B28">
    <label>28.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Evans CM, Koo JAS. Airway mucus: the good, the bad, the sticky. Pharmacol Therapeut. 2009;121:332-48.</mixed-citation>
     <mixed-citation xml:lang="en">Evans CM, Koo JAS. Airway mucus: the good, the bad, the sticky. Pharmacol Therapeut. 2009;121:332-48.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B29">
    <label>29.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Londahl J, Massling A, Pagels J, Swietlicki E, Vaclavik E, Loft S. Size-resolved respiratory-tract deposition of fine and ultrafine hydrophobic and hygroscopic aerosol particles during rest and exercise. Inhal. Toxicol. 19(2), 109-16 (2007).</mixed-citation>
     <mixed-citation xml:lang="en">Londahl J, Massling A, Pagels J, Swietlicki E, Vaclavik E, Loft S. Size-resolved respiratory-tract deposition of fine and ultrafine hydrophobic and hygroscopic aerosol particles during rest and exercise. Inhal. Toxicol. 19(2), 109-16 (2007).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B30">
    <label>30.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Dunne RB, Shortt S. Comparison of bronchodilator administration with vibrating mesh nebulizer and standard jet nebulizer in the emergency department. Am J Emerg Med. 2017 Oct 31.</mixed-citation>
     <mixed-citation xml:lang="en">Dunne RB, Shortt S. Comparison of bronchodilator administration with vibrating mesh nebulizer and standard jet nebulizer in the emergency department. Am J Emerg Med. 2017 Oct 31.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B31">
    <label>31.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Tashkin  DP, Ferguson GT, Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease, Tashkin and Ferguson Respiratory Research 2013, http://respiratory-research.com/content/14/1/49</mixed-citation>
     <mixed-citation xml:lang="en">Tashkin  DP, Ferguson GT, Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease, Tashkin and Ferguson Respiratory Research 2013, http://respiratory-research.com/content/14/1/49</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B32">
    <label>32.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kerstjens Huib A.M., , Brand Paul L.P., Hughes MD., Robinson N. Jamie A Comparison of Bronchodilator Therapy with or without Inhaled Corticosteroid Therapy for Obstructive Airways Disease N Engl J Med 1992; 327:1413-1419</mixed-citation>
     <mixed-citation xml:lang="en">Kerstjens Huib A.M., , Brand Paul L.P., Hughes MD., Robinson N. Jamie A Comparison of Bronchodilator Therapy with or without Inhaled Corticosteroid Therapy for Obstructive Airways Disease N Engl J Med 1992; 327:1413-1419</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B33">
    <label>33.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Barker AF., Couch L., Fiel SB., Gotfried MH., Ilowite J., Meyer KC., O'donnell A.  Tobramycin Solution for Inhalation Reduces Sputum Pseudomonas aeruginosa Density in Bronchiectasis American Journal of Respiratory and Critical Care Medicine Vol. 162, No. 2 | Aug 01, 2000</mixed-citation>
     <mixed-citation xml:lang="en">Barker AF., Couch L., Fiel SB., Gotfried MH., Ilowite J., Meyer KC., O'donnell A.  Tobramycin Solution for Inhalation Reduces Sputum Pseudomonas aeruginosa Density in Bronchiectasis American Journal of Respiratory and Critical Care Medicine Vol. 162, No. 2 | Aug 01, 2000</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B34">
    <label>34.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ryan G, Singh M, Dwan K Inhaled antibiotics for long-term therapy in cystic fibrosis. Cochrane Database Syst Rev. 2011;3: CD001021.</mixed-citation>
     <mixed-citation xml:lang="en">Ryan G, Singh M, Dwan K Inhaled antibiotics for long-term therapy in cystic fibrosis. Cochrane Database Syst Rev. 2011;3: CD001021.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B35">
    <label>35.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kapustina V., Ovcharenko S.  The efficacy and safety of inhaled fluimucil-antibiotic-IT in the treatment of exacerbations of COPD and chronic bronchitis with bronchiectasis European Respiratory Journal 2013 42</mixed-citation>
     <mixed-citation xml:lang="en">Kapustina V., Ovcharenko S.  The efficacy and safety of inhaled fluimucil-antibiotic-IT in the treatment of exacerbations of COPD and chronic bronchitis with bronchiectasis European Respiratory Journal 2013 42</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B36">
    <label>36.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Poole Ph., Black PN., Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease, Cochrane Database Syst Rev. 2010; 2 (CD001287.)</mixed-citation>
     <mixed-citation xml:lang="en">Poole Ph., Black PN., Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease, Cochrane Database Syst Rev. 2010; 2 (CD001287.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B37">
    <label>37.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Qiu Yuan-Hua, Chen En-Guo, Dai Yuan-Rong, Ren Zhen-Yi Efficacy and Safety of Domestic Inhaled N-acetyl-L-cysteine Solution in Mucolytic Therapy Chinese Pharmaceutical Journal 2012-21</mixed-citation>
     <mixed-citation xml:lang="en">Qiu Yuan-Hua, Chen En-Guo, Dai Yuan-Rong, Ren Zhen-Yi Efficacy and Safety of Domestic Inhaled N-acetyl-L-cysteine Solution in Mucolytic Therapy Chinese Pharmaceutical Journal 2012-21</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B38">
    <label>38.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Розенберг О. А., Легочный сурфактант и его применение при заболеваниях легких, Общая реаниматология, 2007, том 3; №1</mixed-citation>
     <mixed-citation xml:lang="en">Rozenberg O. A., Legochnyy surfaktant i ego primenenie pri zabolevaniyah legkih, Obschaya reanimatologiya, 2007, tom 3; №1</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B39">
    <label>39.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">J.M.Borroa, A.Soléb, M.de la Torrea, A.Pastorb, R.Fernandeza, A.Saurab, M.Delgadoa, E.Monteb, D.Gonzaleza  Efficiency and Safety of Inhaled Amphotericin B Lipid Complex (Abelcet) in the Prophylaxis of Invasive Fungal Infections Following Lung Transplantation Transplantation Proceedings Volume 40, Issue 9, November 2008, Pages 3090-3093</mixed-citation>
     <mixed-citation xml:lang="en">J.M.Borroa, A.Soléb, M.de la Torrea, A.Pastorb, R.Fernandeza, A.Saurab, M.Delgadoa, E.Monteb, D.Gonzaleza  Efficiency and Safety of Inhaled Amphotericin B Lipid Complex (Abelcet) in the Prophylaxis of Invasive Fungal Infections Following Lung Transplantation Transplantation Proceedings Volume 40, Issue 9, November 2008, Pages 3090-3093</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B40">
    <label>40.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">S. GargEmail authorJ. RosenstockB. L. SilvermanB. SunC. S. KonkoyA. de la PeñaD. B. Muchmore Efficacy and safety of preprandial human insulin inhalation powder versus injectable insulin in patients with type 1 diabetes Diabetologia May 2006, 49:891</mixed-citation>
     <mixed-citation xml:lang="en">S. GargEmail authorJ. RosenstockB. L. SilvermanB. SunC. S. KonkoyA. de la PeñaD. B. Muchmore Efficacy and safety of preprandial human insulin inhalation powder versus injectable insulin in patients with type 1 diabetes Diabetologia May 2006, 49:891</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B41">
    <label>41.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Abigail L. Chua, Stephen Silberstein Inhaled drug therapy development for the treatment of migraine Expert Opinion on Pharmacotherapy Volume 17, 2016 - Issue 13</mixed-citation>
     <mixed-citation xml:lang="en">Abigail L. Chua, Stephen Silberstein Inhaled drug therapy development for the treatment of migraine Expert Opinion on Pharmacotherapy Volume 17, 2016 - Issue 13</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B42">
    <label>42.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Roncero Carlos, Ros-Cucurull Elena, Grau-López Lara, Fadeuilhe Christian, Casas Miguel,  Effectiveness of Inhaled Loxapine in Dual-Diagnosis Patients: A Case Series Clinical Neuropharmacology: July/August 2016 - Volume 39 - Issue 4 - p 206-209</mixed-citation>
     <mixed-citation xml:lang="en">Roncero Carlos, Ros-Cucurull Elena, Grau-López Lara, Fadeuilhe Christian, Casas Miguel,  Effectiveness of Inhaled Loxapine in Dual-Diagnosis Patients: A Case Series Clinical Neuropharmacology: July/August 2016 - Volume 39 - Issue 4 - p 206-209</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B43">
    <label>43.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Timothy Aksamit, Tiemo-JoergBandel, MargaritaCriollo, Anthony De Soyza, J  Stuart Elborn, ElisabethOperschall, Eva Polverino The RESPIRE trials: Two phase III, randomized, multicentre, placebo-controlled trials of Ciprofloxacin Dry Powder for Inhalation (Ciprofloxacin DPI) in non-cystic fibrosis bronchiectasis Contemporary Clinical Trials Volume 58, July 2017, Pages 78-85</mixed-citation>
     <mixed-citation xml:lang="en">Timothy Aksamit, Tiemo-JoergBandel, MargaritaCriollo, Anthony De Soyza, J  Stuart Elborn, ElisabethOperschall, Eva Polverino The RESPIRE trials: Two phase III, randomized, multicentre, placebo-controlled trials of Ciprofloxacin Dry Powder for Inhalation (Ciprofloxacin DPI) in non-cystic fibrosis bronchiectasis Contemporary Clinical Trials Volume 58, July 2017, Pages 78-85</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B44">
    <label>44.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kenneth N. Olivier, David E. Griffith, Gina Eagle, John P. McGinnis II, Liza Micioni, Keith Liu, Charles L. Daley, Kevin L. Winthrop, Stephen Ruoss, Doreen J. Addrizzo-Harris, Patrick A. Flume, Randomized Trial of Liposomal Amikacin for Inhalation in Nontuberculous Mycobacterial Lung Disease, American Journal of Respiratory and Critical Care Medicine, Vol. 195, No. 6 | Mar 15, 2017</mixed-citation>
     <mixed-citation xml:lang="en">Kenneth N. Olivier, David E. Griffith, Gina Eagle, John P. McGinnis II, Liza Micioni, Keith Liu, Charles L. Daley, Kevin L. Winthrop, Stephen Ruoss, Doreen J. Addrizzo-Harris, Patrick A. Flume, Randomized Trial of Liposomal Amikacin for Inhalation in Nontuberculous Mycobacterial Lung Disease, American Journal of Respiratory and Critical Care Medicine, Vol. 195, No. 6 | Mar 15, 2017</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B45">
    <label>45.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Onur Turan, Pakize Ayse Turan, Arzu Miric Parameters affecting inhalation therapy adherence in elderly patients with chronic obstructive lung disease and asthma,  Geriatrics &amp; Gerontology International ,Volume 17, Issue 6 June 2017 Pages 999-1005</mixed-citation>
     <mixed-citation xml:lang="en">Onur Turan, Pakize Ayse Turan, Arzu Miric Parameters affecting inhalation therapy adherence in elderly patients with chronic obstructive lung disease and asthma,  Geriatrics &amp; Gerontology International ,Volume 17, Issue 6 June 2017 Pages 999-1005</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B46">
    <label>46.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">El Baou C, Di Santostefano RL, Alfonso-Cristancho R, et al. Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis. BMC Pulm Med. 2017;17(1):31</mixed-citation>
     <mixed-citation xml:lang="en">El Baou C, Di Santostefano RL, Alfonso-Cristancho R, et al. Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis. BMC Pulm Med. 2017;17(1):31</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B47">
    <label>47.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Tony Velkov, Nusaibah Abdul Rahim, Qi (Tony) Zhou, Hak-Kim Chan, Jian Lia Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead, Adv Drug Deliv Rev. 2015 May; 85: 65-82</mixed-citation>
     <mixed-citation xml:lang="en">Tony Velkov, Nusaibah Abdul Rahim, Qi (Tony) Zhou, Hak-Kim Chan, Jian Lia Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead, Adv Drug Deliv Rev. 2015 May; 85: 65-82</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B48">
    <label>48.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Jia-Wei Yang, Li-Chao Fan, Hai-Wen Lu, Xia-Yi Miao, Bei Mao, Jin-Fu Xu Efficacy and safety of long-term inhaled antibiotic for patients with noncystic fibrosis bronchiectasis: a meta-analysis, The Clinical Respiratory Journal, Volume 10, Issue 6 November 2016 Pages 731-739</mixed-citation>
     <mixed-citation xml:lang="en">Jia-Wei Yang, Li-Chao Fan, Hai-Wen Lu, Xia-Yi Miao, Bei Mao, Jin-Fu Xu Efficacy and safety of long-term inhaled antibiotic for patients with noncystic fibrosis bronchiectasis: a meta-analysis, The Clinical Respiratory Journal, Volume 10, Issue 6 November 2016 Pages 731-739</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B49">
    <label>49.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Jonkman K, Duma A, Velzen M, Dahan A. Br J Anaesth., Ketamine inhalation. 2017 Feb;118(2):268-269.</mixed-citation>
     <mixed-citation xml:lang="en">Jonkman K, Duma A, Velzen M, Dahan A. Br J Anaesth., Ketamine inhalation. 2017 Feb;118(2):268-269.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
