Medical Radiology and radiation safety

Медицинская радиология и радиационная безопасность

1024-6177 2618-9615

28900

10.12737/article_5cf3dfefe60b13.90120976

Лучевая диагностика

Diagnostic radiology

Лучевая диагностика

Single-Photon Emission Computerized Tomography in the Diagnosis and Monitoring of Lymphomas

Однофотонная эмиссионная компьютерная томография в диагностике и мониторинге лимфопролиферативных заболеваний

Чернов

В. И.

Chernov

V. I.

доктор медицинских наук;

doctor of medical sciences;

Дудникова

Е. А.

Dudnikova

E. A.

Гольдберг

В. Е.

Goldberg

V. E.

доктор медицинских наук;

doctor of medical sciences;

Кравчук

Т. Л.

Kravchuk

T. L.

кандидат медицинских наук;

candidate of medical sciences;

Данилова

А. В.

Danilova

A. V.

Зельчан

Р. В.

Zel'chan

R. V.

кандидат медицинских наук;

candidate of medical sciences;

Медведева

А. А.

Medvedeva

A. A.

кандидат медицинских наук;

candidate of medical sciences;

Синилкин

И. Г.

Sinilkin

I. G.

кандидат медицинских наук;

candidate of medical sciences;

Брагина

О. Д.

Bragina

O. D.

кандидат медицинских наук;

candidate of medical sciences;

Белевич

Ю. В.

Belevich

Yu. V.

Королева

Е. С.

Koroleva

E. S.

кандидат медицинских наук;

candidate of medical sciences;

Национальный исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук» Томск Россия Tomsk National Research Medical Center Tomsk Russian Federation

Национальный исследовательский Томский политехнический университет Томск Россия National Research Tomsk Polytechnic University Tomsk Russian Federation

Национальный исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук» Томск Россия Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science Tomsk Russian Federation

Сибирский государственный медицинский университет Томск Россия Siberian State Medical University Tomsk Russian Federation

64 3 58 63

https://zh-szf.ru/en/nauka/article/28900/view

Несмотря на высокую эффективность применения ПЭТ с 18F-ФДГ в диагностике, стадировании, мониторинге и прогнозе лечения лимфопролиферативных заболеваний, применение этого метода в нашей стране ограничено из-за высокой стоимости исследования и недостаточного количества ПЭТ-центров. В связи с этим представляется актуальным проведение научных исследований, направленных на применение известных и разработку оригинальных радиофармпрепаратов (РФП) для визуализации лимфом методом однофотонной эмиссионной компьютерной томографии (ОФЭКТ). В данном обзоре рассмотрены основные РФП (67Ga-цитрат, 201Tl-хлорид, 199Tl-хлорид, 99mTc-метокси-изобутил-изонитрил, 99mTc-тетрофосмин, 111In-октреотид), применение которых возможно для визуализации лимфом с помощью ОФЭКТ. Проанализированы особенности их применения, механизмы действия, возможности их использования при различных морфологических вариантах и локализациях поражения. Представлены результаты применения инновационного РФП 99mTc-1-тио-D-глюкоза, который является перспективным для диагностики, стадирования и мониторинга лимфопролиферативных заболеваний.

Despite the high efficiency of the use of 18F-FDG PET in the diagnosis, staging, monitoring and prognosis of treatment of lymphomas, the use of this method in our country is limited due to the high cost and the insufficient number of PET-centers. In this regard, it seems relevant to conduct research aimed at using known and developing original radiopharmaceuticals for lymphoma imaging with single-photon emission computed tomography (SPECT). In this review, the main radiopharmaceuticals (67Ga-citrate, 201Tl, 199Tl, 99mTc-methoxy-isobutyl-isonitrile, 99mTc-tetrofosmin, 111In-octreotide), which are possible for SPECT lymphoma imaging are shown. Also mechanisms of their action, the possibility of their using for various morphological variants of lymphomas and localizations of the lesion are described. In addition, the results of the use of an innovative radiopharmaceutical based on glucose - 99mTc-1-thio-D-glucose, which is promising for diagnostics, staging and monitoring of lymphoproliferative diseases, are presented.

лимфопролиферативные заболевания лимфома Ходжкина неходжкинские лимфомы однофотонная эмиссионная компьютерная томография 67Ga-цитрат таллий-201 таллий-199 99mTc-метокси-изобутил-изонитрил 99mTc-тетрофосмин 111In-октреотид 99mTc-1-Тио-D-глюкоза

lymphoproliferative disease Hodgkin's lymphoma non-Hodgkin's lymphomas single-photon emission computed tomography 67Ga-citrate thallium-201 thallium-199 99mTc-methoxy-isobutyl-isonitrile 99mTc-tetrofosmin 111In-octreotide 99mTc-1-Thio -D-glucose

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