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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Journal of New Medical Technologies. eJournal</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Journal of New Medical Technologies. eJournal</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Вестник новых медицинских технологий. Электронный журнал</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2075-4094</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">4702</article-id>
   <article-id pub-id-type="doi">10.12737/7380</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>LITERATURE REVIEWS</subject>
    </subj-group>
    <subj-group>
     <subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">Rheumatic diseases and pregnancy (review)</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Ревматоидные заболевания и беременность (обзор литературы)</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Мишина</surname>
       <given-names>Ю. В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Mishina</surname>
       <given-names>Yu. В.</given-names>
      </name>
     </name-alternatives>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Барсукова</surname>
       <given-names>Н.  А.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Barsukova</surname>
       <given-names>N.  А.</given-names>
      </name>
     </name-alternatives>
    </contrib>
   </contrib-group>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2014-12-26T00:00:00+03:00">
    <day>26</day>
    <month>12</month>
    <year>2014</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2014-12-26T00:00:00+03:00">
    <day>26</day>
    <month>12</month>
    <year>2014</year>
   </pub-date>
   <volume>8</volume>
   <issue>1</issue>
   <self-uri xlink:href="https://zh-szf.ru/en/nauka/article/4702/view">https://zh-szf.ru/en/nauka/article/4702/view</self-uri>
   <abstract xml:lang="ru">
    <p>Рассматривается актуальность проблемы беременности пациенток, страдающих ревматоидными заболеваниями. Наступление беременности у больной ревматоидными заболеваниями (РА) рекомендуется при клинической ремиссии заболевания и минимальной лекарственной нагрузке, сохра-няющихся не менее 3-х месяцев до зачатия. При наступлении беременности нередко наблюдается клиническое улучшение РА. Факторы риска осложненного течения РА при беременности – стойкая активность заболевания до зачатия и позитивность по АЦЦП. РА не оказывает прямого воздействия на фертильность, снижение фертильности может наблюдаться при сопутствующих заболеваниях (АФС), а также при приеме некоторых лекарственных препаратов. При отсутствии активности РА беременность протекает без осложнений и оканчивается естественными родами в срок с рождением нормального доношен-ного ребенка. К факторам риска неблагоприятного исхода беременности при РА относят присутствие Ro-SSA/La-SSB и антифосфолипидных антител. Установлены рекомендации по фармакотерапии больной РА, планирующей беременность. Рассматривается допустимая иммуносупрессивная терапия при беременности, особенности ведения родов и послеродового периода у больных РА. Безопасность грудного вскармливания для новорожденных при лекарственной терапии их матерей определяется содержанием в грудном молоке лекарства. Рекомендуется план наблюдения за беременными с РА.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Pregnancy in patients with rheumatic disease is an important and well-recognized problem. The conception is recommended if patient is in clinical remission and pharmacological burden is minimal at least 3 months prior to the conception. There is often a clinical improvement in early pregnancy. Risk factors of complicated pregnancy include persistent high disease activity and positive ACCP.  rheumatoid diseases (RA) does not affect fertility directly, decreased fertility is observed in case of comorbidity (APLS) or some medications. The pregnancy is uncomplicated in inactive RA and results in natural childbirth. Risk factors of complicated delivery include presence of Ro-SSA/La-SSB and anti-phospholipid antibodies. Provided are some general recommenda-tions on pharmacotherapy of patients with RA planning pregnancy. The most commonly used disease-modifying antirheumatic drugs and immunosuppressants are reviewed peripartum and postpartum. Safety for the child is determined by the drug concentration in the milk of breastfeeding mother. Suggested here is a plan on how to manage a rheumatic disease during pregnancy.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>ревматоидные заболевания</kwd>
    <kwd>беременность</kwd>
    <kwd>факторы риска</kwd>
    <kwd>иммуносупрессивная терапия</kwd>
    <kwd>биологические препараты.</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>rheumatic diseases</kwd>
    <kwd>pregnancy</kwd>
    <kwd>risk factors</kwd>
    <kwd>immunosuppressants</kwd>
    <kwd>biological therapy.</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
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</article>
