Medical Radiology and radiation safety Medical Radiology and radiation safety Медицинская радиология и радиационная безопасность 1024-6177 2618-9615 47810 10.12737/1024-6177-2021-66-6-63-70 Ядерная медицина Nuclear medicine Ядерная медицина Current Trends in Targeted Radionuclide Therapy Development СОВРЕМЕННЫЕ ТЕНДЕНЦИИ РАЗВИТИЯ ТАРГЕТНОЙ РАДИОНУКЛИДНОЙ ТЕРАПИИ Воронцова М. С. Vorontsova M. S. Кармакова Т. А. Karmakova T. A. Панкратов А. А. Pankratov A. A. Каприн А. Д. Kaprin A. D. Московский научно-исследовательский онкологический институт (МНИОИ) имени П.А.Герцена, Москва Россия .A. Hertsen Moscow Oncology Research Institute. Moscow, Russia Russian Federation Московский научно-исследовательский онкологический институт (МНИОИ) имени П.А.Герцена, Москва Россия P.A. Hertsen Moscow Oncology Research Institute. Moscow, Russia Russian Federation Московский научно-исследовательский онкологический институт (МНИОИ) имени П.А.Герцена, Москва Россия P.A. Hertsen Moscow Oncology Research Institute. Moscow, Russia Russian Federation Московский научно-исследовательский онкологический институт (МНИОИ) имени П.А.Герцена, Москва Россия P.A. Hertsen Moscow Oncology Research Institute. Moscow, Russia Russian Federation 66 6 63 70 17 12 2021 https://zh-szf.ru/en/nauka/article/47810/view

СОДЕРЖАНИЕ Введение 1. Особенности адресной доставки терапевтических радионуклидов 2. Дизайн препаратов для таргетной радионуклидной терапии (ТРНТ) 2.1 Радионуклиды 2.2 Синтез радиоконъюгатов 2.3 Векторные носители 3. Субклеточное нацеливание радионуклидов 4. Дозиметрия при ТРНТ Заключение

Introduction 1. Features of Targeted Delivery of Therapeutic Radionuclides 2. Design of Pharmaceuticals for Targeted Radionuclide Therapy (TRT) 2.1. Radionuclides 2.2. Synthesis of Radioconjugates 2.3. Targeting Carriers 4. Subcellular Targeting of Radionuclides 5. TRT Dosimetry Conclusion

 солидные злокачественные опухоли таргетная радионуклидная терапия cancer solid tumors targeted radionuclide therapy

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