The authors described a case of a rare, asymptomatic form of tumors of the retroperitoneal space (leiomyoma) with a successful outcome in the young man, 19 years old. Connective tissue mast cells were detected in the tumor and examined. The instability of their population is morphologically obvious, and morpho-functional parameters in different areas of the tumor are heterogeneous. A slight amount of mast cells have been detected in dense parts and nodular tumors. Their number and degree of degranulation were highest in areas of inflammation and plethora, as well as on the periphery of the cystic parts of the tumor. The reactivity of a population of mast cells in the processes of tumor formation was confirmed morphologically by the results of this study. It is recommended to consider with prognostic purposes and with a view to developing optimal therapeutic and preventive strategies.
leiomyoma, retroperitoneal tumor, mast cells, young man
1. Vasil´ev Yu.M. Soedinitel´naya tkan´ i opukholevyy rost v eksperimente. M.: Medgiz. 1961. 139 s.
2. Vershinina S.F., Potyavina E.V. Primenenie prirodnykh regulyatorov v onkologii. Voprosy onkologii. 2003. T. 49. №2. S. 145-151.
3. Vinogradov V.V., Vorob´eva N.F. Tuchnye kletki. N., 1973. 120 s.
4. Dzodzikova M.E. Tuchnye kletki cheloveka i zhivotnykh v protsesse razvitiya raka molochnoy zhelezy . Avtoreferat dissertatsii na soiskanie uchenoy stepeni doktora biologicheskikh nauk. Moskva, 2006. 46 s.
5. Dzodzikova M.E., Alaverdova S.A., Pogosyan A.A., Turieva D.V. Zlokachestvennye novoobra-zovaniya predstatel´noy zhelezy u muzhchin RSO-Alaniya.// Mat. XII Vseross. onkologich. kongr. Moskva, 2008. C. 206-207.
6. Dzodzikova M.E., Berezov T.T. Zabolevaemost´ zlokachestvennymi novoobrazovaniyami v res-publike Severnaya Osetiya Alaniya v 1991-2000 gg.. zh. Voprosy onkologii. 2003. T.49, №2. S. 181-185.
7. Dzodzikova M.E., Berezov T.T., Shakhlamov V.A., Salbiev K.D. Tuchnye kletki molochnoy zhelezy v protsesse formirovaniya raka molochnoy zhelezy v eksperimente.. Vestnik VNTs RAN. 2003. №4. S. 37-43.
8. Dzodzikova M.E.,Turieva D.V., Pogosyan A.A., Kasabieva E.E. Lekarstvennye rasteniya Sever-noy Osetii v lechenii opukholey molochnoy zhelezy.. Sb. tr. Vseross.konf. «Floristicheskie issledova-niya Severnogo Kavkaza». g. Groznyy, 2011. S. 57-59.
9. Dzodzikova M.E., Dzugkoeva F.S., Kastueva N.Z., Akkalaev A.M. Vozrastnye aspekty zabole-vaemosti zlokachestvennymi novoobrazovaniyami naseleniya RSO-Alaniya v 1997-1999 gg.. III Ukra-inskaya konferentsiya, posvyashchennaya pamyati akademika V. V. Frol´kisa. Institut geront. AMN Ukrainy.-Kiev, 2002. S. 172-173.
10. Dzodzikova M.E., Suanova L.A., Salbiev K.D., Doev G.S., Kakabadze S.A., Kataeva D.G., Ba-sieva F. M. Endoskopicheskie aspekty diagnostiki zlokachestvennykh novoobrazovaniy legkikh. Vestnik VNTs RAN. 2006. T.6, №3. S. 65-69.
11. Dzodzikova M.E., Suanova L.A., Soltanova E.E., Alaverdova S.A. Retrospektivnyy analiz zabolevaemosti rakom legkogo v Severnoy Osetii-Alanii s 1990 po 2005 gody. Mat 7-y mezhduna-rodn.nauch.-praktich. konf. «Zdorov´e i obrazovanie v KhKhI veke». Moskva, 2006. S.481-482.
12. Dzodzikova M.E., Turiev A.V. Zlokachestvennye novoobrazovaniya predstatel´noy zhelezy u muzhchin Severnoy Osetii.. Mat. mezhdunar. nauch.-prakt. konf. «Aktual´nye problemy zashchity okru-zhayushchey sredy i tekhnosfernoy bezopasnosti v menyayushchikhsya antropogennykh usloviyakh» - «Belye nochi-2014». Groznyy, 2014. S. 105-109.
13. Dzodzikova M.E., Turiev A.V., Turieva D.V., Dzhadzhieva M.Yu., Butaeva F.M. Zabolevaemost´ i smertnost´ pri zlokachestvennykh novoobrazovaniyakh molochnoy zhelezy u zhenshchin Severnoy Osetii.. Elektr-y nauchno-obraz-y Vestnik "Zdorov´e i obrazovanie v XXI veke". 2014. T.16, №4. S.18-20.
14. Durnov L.A., Bukhny F.A., Lebedev V.I. Opukholi zabryushinnogo prostranstva i bryushnoy polosti u detey. M.: Meditsina, 1972. 320 s.
15. Letyagin V.P., Protchenko N.V., Rybakov Yu.L., Dobrynin Ya.V. Opyt primeneniya vikhrevogo magnitnogo polya v lechenii raka molochnoy zhelezy. Voprosy onkologii. 2003. T.49, №6. S. 748-751.
16. Ovsienko V.V. Kontaktnoe vzaimodeystvie tuchnykh kletok i limfotsitov pri opukholevom roste . Avtoref. dis. … kand. biol. nauk: 14.00.14. AN USSR. Inst. Probl. Onkologii im. R.E. Kavets-kogo. Kiev, 1998. 19 s.
17. Chisov V.I. Zlokachestvennye novoobrazovaniya v Rossii v 2011 godu.(pod red. Chisova V.I., Starinskogo V.V., Petrovoy G.V.). M.: FGBU «MNIOI im. P.A. Gertsena» Minzdrava Rossii, 2013. 289 s.
18. Yurina N.A., Radostina A.I. Morfofunktsional´naya geterogennost´ i vzaimodeystvie kletok soedinitel´noy tkani. M.: Izd. UDN, 1990. 398 s.
19. Anderson L.E., Morris J.E., Sasser L.B., Stevens R.J. Effect jf constant light on DMBA mammary tumorgenesis in rats. Cancer Lett. 2000. V. 148. P. 121-126.
20. Bowrey PF, King J, Magarey C, Schwartz P, Marr P, Bolton E, Morris DL. Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect?. Br J Cancer. 2000. 82(1). P. 167-170.
21. Enerback L. Mucosal mast cell in the rat and man.. Ant. Allergy Appl. Immunol. 1987. V.82, No 3-4. R. 246-255.
22. Kaliner M.A. and Metcalfe D.D. The Mast Cell in Health and Disease. New York: Dekker, 1993.
23. Meininger C.J. Mast cells and tumor-associated angiogenesis. Chem. Immunol. 1995. 62. R. 239-257.
24. Metcalfe D.D., Baram D., Mekori Y. Mast cells. Physiol. Rev. 1997. Vol. 77. P. 1033-1079.
25. Global cancer statistics / Parkin D.M. [et al]. CA Cancer Journal for Clinicians. 2005. 55. P. 74-108.
26. Rodewald H.R., M. Dessing, A.M. Dvorak and S.J. Galli: Identification of a committed precursor for the mast cell lineage. Science. 1996. 271. R. 818-822.
27. Samoszuk M., Corwin M.A. Mast cell inhibitor cromolyn increases blood clotting and hypoxia in murine breast cancer.. Int J Cancer. 2003. 107(1). R. 159-163.
28. Samoszuk M.K., Nguyen V., Gluzman R., Pham J.H. Occult deposition of eosinophil peroxidase in a subset of human breast carcinomas.. Am J Pathol. 1996. V. 148(3). R. 701-706.
29. Selye H. The Mast Cell. Butterworths, Washington, 1965. 498 r.
