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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Journal of Natural Sciences Research</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Journal of Natural Sciences Research</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Журнал естественнонаучных исследований</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2500-0489</issn>
   <issn publication-format="online">2500-0489</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">85225</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>Медицинские науки</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>MEDICINE SCIENCE</subject>
    </subj-group>
    <subj-group>
     <subject>Медицинские науки</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">Syndemia of chronic obstructive pulmonary disease and cardiovascular diseases</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Синдемия хронической обструктивной болезни легких и сердечно-сосудистых заболеваний</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Холомина</surname>
       <given-names>А. Ю.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Holomina</surname>
       <given-names>A. Yu.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">ООО ЭВЕР Нейро Фарма</institution>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">EVER Neuro Farma LLC</institution>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">ООО МСД ФАРМАСЬЮТИКАПС</institution>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">MSD PHARMACEUTICALS LLC</institution>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2024-07-09T15:49:24+03:00">
    <day>09</day>
    <month>07</month>
    <year>2024</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2024-07-09T15:49:24+03:00">
    <day>09</day>
    <month>07</month>
    <year>2024</year>
   </pub-date>
   <volume>9</volume>
   <issue>2</issue>
   <fpage>52</fpage>
   <lpage>55</lpage>
   <history>
    <date date-type="received" iso-8601-date="2024-07-08T00:00:00+03:00">
     <day>08</day>
     <month>07</month>
     <year>2024</year>
    </date>
   </history>
   <self-uri xlink:href="https://zh-szf.ru/en/nauka/article/85225/view">https://zh-szf.ru/en/nauka/article/85225/view</self-uri>
   <abstract xml:lang="ru">
    <p>В статье рассматривается проблема коморбидности хронической обструктивной болезни легких и сердечно-сосудистых заболеваний, которая на сегодняшний день приобрела характер синдемии. Анализируется распространенность этих патологий и их совместного течения, описываются общие патофизиологические механизмы и биомаркеры, лежащие в основе взаимоотягощающего течения указанных патологий. Уделено внимание особенностям применения сердечно-сосудистых препаратов у пациентов с хронической обструктивной болезнью легких и их влиянию на течение респираторной патологии. Рассматривается прогностическое значение коморбидности описываемого континуума, ассоциированный с ней повышенный риск неблагоприятных исходов.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>The article deals with the problem of comorbidity of chronic obstructive pulmonary disease and cardiovascular diseases, which has acquired the character of syndemia to date. The prevalence of these pathologies and their joint course is analyzed. The general pathophysiological mechanisms and biomarkers underlying the mutually aggravating course of these pathologies are described. Attention is paid to the peculiarities of the use of cardiovascular drugs in patients with chronic obstructive pulmonary disease and their effect on the course of respiratory pathology. The prognostic value of comorbidity of the described continuum and the associated increased risk of adverse outcomes are considered.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>хроническая обструктивная болезнь легких</kwd>
    <kwd>коморбидность</kwd>
    <kwd>сердечнососудистые заболевания</kwd>
    <kwd>синдемия</kwd>
    <kwd>предиктивная диагностик</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>chronic obstructive pulmonary disease</kwd>
    <kwd>comorbidity</kwd>
    <kwd>cardiovascular diseases</kwd>
    <kwd>syndemia</kwd>
    <kwd>predictive diagnosis</kwd>
   </kwd-group>
  </article-meta>
 </front>
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  <p></p>
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