Clinical Medicine and Pharmacology Clinical Medicine and Pharmacology Клиническая медицина и фармакология 2409-3750 89366 10.12737/2409-3750-2024-10-2-5-8 Клинические наблюдения clinical observations Клинические наблюдения Chronic myeloproliferative disease Хроническое миелопролиферативное заболевание Долгополов М. С. Dolgopolov M. S. Тульский государственный университет Tula State University 04 10 2024 04 10 2024 10 2 5 8 04 10 2024 https://zh-szf.ru/en/nauka/article/89366/view

Хронические миелопролиферативные заболевания являются актуальной проблемой современной гематологии. Несмотря на то, что это относительно редкие патологии системы крови, пациенты с миелопролиферативными заболеваниями регулярно встречаются в практике гематолога. Возросший за последнее время интерес к этой группе заболеваний обусловлен увеличением частоты их диагностики у пациентов разного возраста. Представлено клиническое наблюдения пациента среднего возраста, трудности диагностики и подбора терапии

Chronic myeloproliferative diseases are an urgent problem of modern hematology. Despite the fact that these are relatively rare pathologies of the blood system, patients with myeloproliferative diseases are regularly encountered in the practice of a hematologist. The recent increased interest in this group of diseases is due to the increased frequency of their diagnosis in patients of different ages. A clinical observation of a middle-aged patient, diagnostic difficulties and therapy selection is presented.

 миелопролиферативное заболевание неспецифические симптомы гидроксикарбамид myeloproliferative disease nonspecific symptoms hydroxycarbamide

Kutti J., Ridell B. Epidemiology of the myeloproliferative disorders: essential thrombocythaemia, polycythaemiavera and idiopathic myelofibrosis. // Pathol. Biol., 2001, v.4, p.164-164; Kutti J., Ridell B. Epidemiology of the myeloproliferative disorders: essential thrombocythaemia, polycythaemiavera and idiopathic myelofibrosis. // Pathol. Biol., 2001, v.4, p.164-164; Johansson P., Kutti J., Andreasson B., Safai-Kutti S., Vilen L., Wedel H., Ridell B. Trends in the incidence of chronic Philadelphia chromosome negative (Ph-) myeloproliferative disorders in the city of Goteborg, Sweden, during 1983-99. // Journal of Internal Medicine, 2004, v.256,p.161-165; Johansson P., Kutti J., Andreasson B., Safai-Kutti S., Vilen L., Wedel H., Ridell B. Trends in the incidence of chronic Philadelphia chromosome negative (Ph-) myeloproliferative disorders in the city of Goteborg, Sweden, during 1983-99. // Journal of Internal Medicine, 2004, v.256,p.161-165; Bangerter M., Guthner С., Beneke H. et al. Pregnancy in essential thrombo-cythaemia: treatment and outcome of 17 pregnancies. // Eur. J. Haematol., 2000,v. 65, № 3, p. 165-169; Bangerter M., Guthner S., Beneke H. et al. Pregnancy in essential thrombo-cythaemia: treatment and outcome of 17 pregnancies. // Eur. J. Haematol., 2000,v. 65, № 3, p. 165-169; Hasselbalch H.C. Idiopathic myelofibrosis: a review. // Eur. J. Hematol., 1990,v. 45, N 2, p. 65-72; Hasselbalch H.C. Idiopathic myelofibrosis: a review. // Eur. J. Hematol., 1990,v. 45, N 2, p. 65-72; Heis-Vahidi-Fard N., Forberg E., Eichinger S. et al. Ineffectiveness of interferon-gamma in the treatment of idiopathic myelofibrosis: a pilot study. // Ann. Hematol, 2001, v. 80,N 2, p.79-82; Heis-Vahidi-Fard N., Forberg E., Eichinger S. et al. Ineffectiveness of interferon-gamma in the treatment of idiopathic myelofibrosis: a pilot study. // Ann. Hematol, 2001, v. 80,N 2, p.79-82; Злокачественные новообразования в России в 1998 году (заболеваемость и смертность). Под ред. В.И. Чиссова, В.В. Старинского, М.: МНИОИ им. П.А. Герцена, 1999, 288 с; Zlokachestvennye novoobrazovaniya v Rossii v 1998 godu (zabolevaemost' i smertnost'). Pod red. V.I. Chissova, V.V. Starinskogo, M.: MNIOI im. P.A. Gercena, 1999, 288 s; Bain B.J. The relationship between the myelodysplastic syndromes and the myeloproliferative disorders. // Leuk. Lymphoma, 1999, v. 34, № 5-6, p. 443-449; Bain B.J. The relationship between the myelodysplastic syndromes and the myeloproliferative disorders. // Leuk. Lymphoma, 1999, v. 34, № 5-6, p. 443-449; Kutti J., Ridell B. Epidemiology of the myeloproliferative disorders: essential thrombocythaemia, polycythaemiavera and idiopathic myelofibrosis. // Pathol. Biol. (Paris), 2001, v. 49, N 2, p. 164-166; Kutti J., Ridell B. Epidemiology of the myeloproliferative disorders: essential thrombocythaemia, polycythaemiavera and idiopathic myelofibrosis. // Pathol. Biol. (Paris), 2001, v. 49, N 2, p. 164-166; Клиническая онкогематология, ред. Волковой М.А. М.; 2001, c.263-300; Klinicheskaya onkogematologiya, red. Volkovoy M.A. M.; 2001, c.263-300; Шиффман Ф. Дж. Патофизиология крови: Пер. с англ., М.,СПб.: "Издательство БИНОМ", "Невский диалект". 2000, 448 с.; Shiffman F. Dzh. Patofiziologiya krovi: Per. s angl., M.,SPb.: "Izdatel'stvo BINOM", "Nevskiy dialekt". 2000, 448 s.; AdamkovМ., Plank L., Szepe P. Occurrence of myelofibrosis in individual types of chronic myeloproliferative diseases. // Bratisl. Lek.Listy, 1998, v. 99, N. 5, p. 240-244; AdamkovM., Plank L., Szepe P. Occurrence of myelofibrosis in individual types of chronic myeloproliferative diseases. // Bratisl. Lek.Listy, 1998, v. 99, N. 5, p. 240-244; Murphy S. Diagnostic criteria and prognosis in polycythemia vera and essential thrombocythemia. // Semin. Hematol., 1999., v.36, N.1, Suppl. 2, p.9-13; Murphy S. Diagnostic criteria and prognosis in polycythemia vera and essential thrombocythemia. // Semin. Hematol., 1999., v.36, N.1, Suppl. 2, p.9-13; Tefferi A., Murphy S. Current opinion in essential thrombocythemia: pathogenesis, diagnosis, and management. // Blood. Rev., 2001, v.15, N.3, p.121-131; Tefferi A., Murphy S. Current opinion in essential thrombocythemia: pathogenesis, diagnosis, and management. // Blood. Rev., 2001, v.15, N.3, p.121-131; Bench A.J., Cross N.C., Huntly B.J. et al. Myeloproliferative disorders. // Best. Pract. Res. Clin. Haematol., 2001, v.14, p.531-551; Bench A.J., Cross N.C., Huntly B.J. et al. Myeloproliferative disorders. // Best. Pract. Res. Clin. Haematol., 2001, v.14, p.531-551; Tefferi A., Vardiman J. W. Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 2008, 22: 14- 22; Tefferi A., Vardiman J. W. Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 2008, 22: 14- 22; AyalewTefferi, Juergen Thiele, and James W. Vardiman. The 2008 World Health Organization Classification System for Myeloproliferative Neoplasms. // Cancer, 2009, v.115, №9, p. 3842-3847; AyalewTefferi, Juergen Thiele, and James W. Vardiman. The 2008 World Health Organization Classification System for Myeloproliferative Neoplasms. // Cancer, 2009, v.115, №9, p. 3842-3847; James W. Vardiman, Julergen Thiele, Daniel A. Arber, Richard D. Brunning, Michael J. Borowitz, Anna Porwit, Nancy Lee Harris, Michelle M. Le Beau, Eva Hellstrom-Lindberg, Ayalew Tefferi, and Clara D. Bloomfield The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. // Blood,2009, v. 114, №5, p.937-951; James W. Vardiman, Julergen Thiele, Daniel A. Arber, Richard D. Brunning, Michael J. Borowitz, Anna Porwit, Nancy Lee Harris, Michelle M. Le Beau, Eva Hellstrom-Lindberg, Ayalew Tefferi, and Clara D. Bloomfield The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. // Blood,2009, v. 114, №5, p.937-951; Соколова Н.А., Савина М.И. // Молодой ученый, 2011, №5, т.2, c. 216-219; Sokolova N.A., Savina M.I. // Molodoy uchenyy, 2011, №5, t.2, c. 216-219; МисюринА.В. Молекулярный патогенез миелопролиферативных заболеваний. // Клиническая онкогематология, 2009, т.2, №3,с.211-219; MisyurinA.V. Molekulyarnyy patogenez mieloproliferativnyh zabolevaniy. // Klinicheskaya onkogematologiya, 2009, t.2, №3,s.211-219; Глузман Д.Ф., Скляренко Л.М., Надгорная В.А., Абраменко И.В. Новая классификация ВОЗ опухолей кроветворной и лимфоидной ткани. // Онкология, 2001, т.3, №4, с.299-300. Gluzman D.F., Sklyarenko L.M., Nadgornaya V.A., Abramenko I.V. Novaya klassifikaciya VOZ opuholey krovetvornoy i limfoidnoy tkani. // Onkologiya, 2001, t.3, №4, s.299-300.