Clinical Medicine and Pharmacology Clinical Medicine and Pharmacology Клиническая медицина и фармакология 2409-3750 109281 10.12737/2409-3750-2025-11-3-8-15 Обзоры reviews Обзоры Relationship between diabetes mellitus and stomach cancer, the effect of metformin on the course of diseases and prognosis Взаимосвязь сахарного диабета и рака желудка, влияние метформина на течение заболеваний и прогноз Радыгина Л. В. Radygina L. V. Барыбкина М. Н. Barybkina M. N. Всероссийский институт научной и технической информации Российской академии наук Россия Всероссийский институт научной и технической информации Российской академии наук Russian Federation Всероссийский институт научной и технической информации Российской академии наук Россия Всероссийский институт научной и технической информации Российской академии наук Russian Federation 03 12 2025 03 12 2025 11 3 8 15 03 12 2025 https://zh-szf.ru/en/nauka/article/109281/view

В статье рассматривается взаимосвязь сахарного диабета и рака желудка и влияние метформина на прогноз у пациентов с этими патологиями. Большинство исследований показывают, что у пациентов с сахарным диабетом риск развития рака желудка повышен. У больных с сахарным диабетом и раком желудка после операции гастрэктомии чаще возникают осложнения, а прогноз может быть хуже, чем у пациентов без сахарного диабета, однако при этом после гастрэктомии у пациентов с сахарным диабетом и раком желудка наблюдается улучшение контроля гликемии. Связь между сахарным диабетом и раком желудка может быть обусловлена общими факторами риска, такими как гипергликемия, неправильное питание, курение, инфекция Helicobacter pylori, а также использование некоторых лекарственных препаратов, например, инсулина, метформина, статинов, аспирина и ингибиторов протонной помпы. Отдельные исследования указывают на снижение риска развития рака желудка у пациентов с сахарным диабетом 2 типа при применении метформина. Это подтверждается данными многочисленных исследований in vitro и на животных моделях. Метформин также может снижать риск инфицирования Helicobacter pylori, который является важным фактором риска развития рака желудка. Также известно, что у пациентов с раком желудка метформин может улучшать выживаемость и снижать частоту рецидивов.

The article discusses the relationship between diabetes mellitus and stomach cancer, as well as the impact of metformin on the prognosis of patients with these conditions. Most studies suggest that patients with diabetes mellitus have an increased risk of developing stomach cancer. Patients with diabetes mellitus and stomach cancer are more likely to experience complications after gastrectomy, and their prognosis may be worse than that of patients without diabetes mellitus. However, patients with diabetes mellitus and stomach cancer may experience improved glycemic control after gastrectomy. The association between diabetes mellitus and gastric cancer may be due to common risk factors such as hyperglycemia, poor diet, smoking, Helicobacter pylori infection, and the use of certain medications, such as insulin, metformin, statins, aspirin, and proton pump inhibitors. Some studies suggest that the use of metformin may reduce the risk of gastric cancer in patients with type 2 diabetes mellitus. This is supported by numerous in vitro and animal model studies. Metformin can also reduce the risk of Helicobacter pylori infection, which is an important risk factor for stomach cancer. Additionally, metformin has been shown to improve survival rates and reduce the incidence of recurrence in patients with stomach cancer.

 сахарный диабет рак желудка гастрэктомия Helicobacter pylori метформин diabetes gastric cancer gastrectomy Helicobacter pylori metformin

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