Medical Radiology and radiation safety Medical Radiology and radiation safety Медицинская радиология и радиационная безопасность 1024-6177 2618-9615 28862 10.12737/article_5cf232752e83d4.66034976 Радиационная медицина Radiation medicine Радиационная медицина Spectral Correlation Analysis of EEG of liquidators of the Chernobyl Accident with Neurological Disorders Спектрально-корреляционный анализ ЭЭГ у ликвидаторов аварии на ЧАЭС с неврологическими нарушениями Торубаров Ф. С. Torubarov F. S.

доктор медицинских наук;

doctor of medical sciences;

 Кулешова М. В. Kuleshova M. V.

кандидат медицинских наук;

candidate of medical sciences;

 Лукьянова С. Н. Luk'yanova S. N. Зверева З. Н. Zvereva Z. F.

доктор медицинских наук;

doctor of medical sciences;

 Самойлов А. С. Samoylov A. S.

доктор медицинских наук;

doctor of medical sciences;

 Федеральный медицинский биофизический центр им. А.И.Бур­на­зяна ФМБА России Москва Россия A.I. Burnasyan Federal Medical Biophysical Center (FMBC) FMBA Moscow Russian Federation Федеральный медицинский биофизический центр им. А.И.Бур­на­зяна ФМБА России Москва Россия A.I. Burnasyan Federal Medical Biophysical Center (FMBC) FMBA Moscow Russian Federation Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА России Москва Россия A.I. Burnasyan Federal Medical Biophysical Center of FMBA Moscow Russian Federation Федеральный медицинский биофизический центр им. А.И.Бур­на­зяна ФМБА России Москва Россия A.I. Burnasyan Federal Medical Biophysical Center (FMBC) FMBA Moscow Russian Federation Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА России Москва Россия A.I. Burnasyan Federal Medical Biophysical Center of FMBA Moscow Russian Federation 64 3 40 45 https://zh-szf.ru/en/nauka/article/28862/view

Цель: Сравнительный анализ спектрально-корреляционных характеристик ЭЭГ у ликвидаторов аварии на ЧАЭС и лиц группы сопоставления, имеющих неврологические нарушения. Материал и методы: Исследование выполнено для 141 ликвидатора аварии на ЧАЭС и 84 человек группы сопоставления. Ионизирующему воздействию могли подвергаться только ликвидаторы. Средняя доза облучения в группе ликвидаторов составила 110±14 мЗв. Группы были сопоставимы по возрасту и трудовой занятости. Все лица прошли клинико-неврологическое и электрофизиологическое обследование в условиях клиники ФМБЦ им. А.И. Бурназяна. Основное внимание было уделено спектрально-корреляционному анализу ЭЭГ. Результаты: Клиническое обследование позволило диагностировать в обеих группах неврологические нарушения в виде: вегетососудистой дистонии, нейроциркуляторной дистонии, дисциркуляторной энцефалопатии различной этиологии – со статистически значимым преобладанием их количества и качества у ликвидаторов. Спектрально-корреляционный анализ ЭЭГ дополняет эти данные, демонстрируя наличие коррелят рассматриваемых нозологий и достоверные различия между группами ликвидаторов и сопоставления. Наблюдаемые у ликвидаторов изменения являются функциональными и носят неспецифический характер. Выводы: В группе ликвидаторов выявлено достоверное увеличение количества и степени выраженности рассматриваемых неврологических нарушений. При этом в спектре ЭЭГ ликвидаторов статистически значимо усиливается индекс дельта-активности и снижается выраженность альфа-диапазона по сравнению с группой сопоставления. Важно, что эти изменения сопровождаются ослаблением корреляционных связей между структурами мозга и нарушением нормальной семиотики ЭЭГ покоя.

Purpose: Comparative analysis of spectral correlation characteristics of EEG from liquidators of the Chernobyl accident and persons group, with neurological disorders. Material and methods: A study carried out with the participation of 141 of the liquidator of the Chernobyl accident and 84 people group. Ionizing effects could be subject only to the liquidators. The average radiation dose in a group of liquidators was 110 ± 14 mSv. Groups were matched on age and employment. All persons have passed clinical neurological and electrophysiological examination. The focus of the article given that spectral and correlation analysis of EEG. Results: Clinical examination made it possible to diagnose neurological disorders in both groups as: vegetovascular dystonia, neurocirculatory dystonia, dyscirculatory encephalopathy of different etiology. Their number and extent dominated statistically in a group of liquidators of the Chernobyl accident. It is important to note that increasing the frequency of their manifestations depending on the liquidators received radiation doses have not been identified. However, the disorder is diagnosed more often in the psychoemotional sphere among liquidators, than in the group mapping (61.7 % and 29.7 %, respectively). The analysis reveals statistically significant differences in EEG spectra in the presence of specified diagnoses compared with known characteristic of norms. Spectral and correlation analysis of EEG complements these data, demonstrating the existence of correlative considered diagnoses and significant differences between groups of liquidators and mappings. Liquidators increased delta-range observed in the authentically greater degree (as compared to a matched group) and combined with a significant reduction in the alpha-frequency index. The observed changes among liquidators are functional and non-specific in nature. Picture of the totality of the observed changes is not specific. It is regarded as one of the non-pathogenic mechanisms of development of the asthenic symptoms of different etiology. Conclusions: In the group of liquidators revealed a significant increase in the quantity and the degree of neurological disorders. In the spectrum of EEG liquidators reliably amplifies the index delta-activity and decreases the severity of alpha range compared to a mappings group. It is important that these changes are accompanied by a weakening of the correlations between brain structures and disruption EEG rest.

 ликвидаторы аварии на ЧАЭС группа сопоставления клинико-неврологическое обследование спектрально-корреляционный анализ ЭЭГ достоверные различия liquidators of the Chernobyl NPP accident group comparison clinical neurological examination spectral and correlation analysis of EEG significant differences

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