Vladivostok, Vladivostok, Russian Federation
student
Russian Federation
Vladivostok, Vladivostok, Russian Federation
UDC 616.31
UDC 50
CSCSTI 34.39
Russian Classification of Professions by Education 31.06.01
Russian Library and Bibliographic Classification 5
Russian Trade and Bibliographic Classification 5
Oxidative stress (OS) is a key pathogenetic mechanism involved in the development of inflammatory periodontal diseases, such as chronic generalized periodontitis and gingivitis. This article presents a review of contemporary studies focusing on the molecular and cellular mechanisms by which free radical processes affect periodontal tissues, the influence of systemic factors (diabetes mellitus, bronchiectasis, stress) on the intensity of oxidative stress, as well as the possibilities of pathogenetic correction using antioxidant therapy. The mechanisms of oxidative damage formation, key biomarkers, and experimental and clinical approaches to reducing oxidative stress are discussed.
oxidative stress, inflammatory periodontal diseases, periodontitis, free radicals, antioxidants, pathogenesis, oxidative stress markers.
1. Galiullina E.F. Sovremennye predstavleniya o roli svobodnoradikal'nyh processov kak odnogo iz puskovyh patogeneticheskih mehanizmov razvitiya zabolevaniy parodonta // Problemy stomatologii. – 2015. – № 1. – S. 25–30.
2. Martusevich A.K., Karuzin K.A., Samoylov A.S. Oksidativnyy stress i ego rol' v formirovanii dizadaptacii i patologii // Bioradikaly i antioksidanty. – 2015. – № 2. – S. 5–18. EDN: https://elibrary.ru/VCFLPP
3. Kibkalo A.P., Sarkisov A.K., Polunina E.A., Sarkisov K.A. Uroven' markerov okislitel'nogo stressa pri generalizovannom parodontite na fone bronhoektaticheskoy bolezni // Kubanskiy nauchnyy medicinskiy vestnik. – 2019. – T. 26, № 5. – S. 42–51. DOI: https://doi.org/10.25207/1608-6228-2019-26-5-42-51; EDN: https://elibrary.ru/WWOPYC
4. Edranov S.S., Kalinichenko S.G., Matveeva N.Yu., Kovaleva I.V. Morfogeneticheskie i rostovye faktory v mehanizmah povrezhdeniya dentino-pul'parnogo kompleksa i periodonta // Tihookeanskiy medicinskiy zhurnal. – 2024. – № 1 (95). – S. 11–16. DOI: https://doi.org/10.34215/1609-1175-2024-1-11-16; EDN: https://elibrary.ru/LDSROU
5. Haydar D.A., Zahvatov A.N., Mosina L.M., Saushev I.V., Tarasova T.V., Zaharkin I.A. Patogeneticheskaya korrekciya oksidativnogo stressa novym proizvodnym 3-gidroksipiridina pri parodontite v eksperimente // International Research Journal. – 2024. – № 147. – S. 2–4.
6. Redinova T.L., Vershinina T.N., Bulavina A.L. Chastota diagnostiki razlichnyh sostoyaniy tkaney parodonta na prieme stomatologa-terapevta i faktory riska parodontita // Tihookeanskiy medicinskiy zhurnal. – 2020. – № 2 (80). – S. 61–63. DOI: https://doi.org/10.34215/1609-1175-2020-2-61-63; EDN: https://elibrary.ru/OGMHFW
7. Ivanov P.V., Malan'in I.V., Stomatov A.V., Gribovskaya Yu.V. Antioksidantnaya terapiya v kompleksnom lechenii parodontita // Fundamental'nye issledovaniya. – 2008. – № 11. – S. 23–27. EDN: https://elibrary.ru/JVMCAP
8. Zaharkin A.G., Adamchik A.A. Antioksidanty v kompleksnom lechenii hronicheskogo generalizovannogo parodontita // Obrazovatel'nyy vestnik «Soznanie». – 2006. – T. 8, № 6. – S. 281. EDN: https://elibrary.ru/UADPER
9. Darenskaya M.A., Goncharov I.S., Kolesnikov S.I., Semenova N.V., Kolesnikova L.I. Parodontit i okislitel'nyy stress: sovremennye tendencii v izuchenii patogeneticheskoy vzaimosvyazi i sposoby korrekcii // Patologicheskaya fiziologiya i eksperimental'naya terapiya. – 2025. – T. 69, № 1. – S. 81–91. DOI: https://doi.org/10.48612/pfiet/0031-2991.2025.01.81-91; EDN: https://elibrary.ru/KNXSCM
10. Nadeev A.D., Zinchenko V.P., Avdonin P.V., Goncharov N.V. Toksicheskie i signal'nye svoystva aktivnyh form kisloroda // Toksikologicheskiy vestnik. – 2014. – № 2 (15). – S. 22–27. EDN: https://elibrary.ru/ZCORMJ
11. Maskurova Yu.V., Gayvoronskaya T.V., Uvarova A.G. Effektivnost' primeneniya antioksidantov v kompleksnom lechenii parodontita sredney i tyazheloy stepeni na fone hronicheskogo stressa // Rossiyskiy stomatologicheskiy zhurnal. – 2016. – T. 20, № 6. – S. 337–340. DOI: https://doi.org/10.18821/1728-28022016;20(6)337-340; EDN: https://elibrary.ru/XWOUCN
12. Zhad'ko S.I. i dr. Rol' okislitel'nogo stressa v patogeneze zabolevaniy parodonta u bol'nyh saharnym diabetom 2 tipa // CRIMTJ Journal. – 2013. – № 2. – S. 37–41.
