Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
The review reveals modern concepts of morphology and biochemistry of the intercellular substance of connective tissue of the skin dermis, as well as the characteristic of its cellular composition (fibroblasts, mast cells, histiocytes). The main physical factors influencing the aging process have been studied. It has been shown that age-related skin changes are associated with the decrease in the number of fibroblasts and the amount of collagen, changes in its structure and the relation between its different types of collagens.
connective tissue, dermis, a basic substance, fibers, fibroblasts, histiocytes, mast cells, skin aging.
1. Alekseev N.T., Glukhov A.A., Ostroushko A.P. The role of fibroblast cells differon in the process of wound healing. Bulletin of experimental and clinical surgery 2012; 5(3):601-608 (in Russian).
2. Arabian E.R. Age-related changes in the dermis, new information and ways of correction by means of daily care. Russkiy meditsinskiy zhurnal 2008; 16(8):574-575 (in Russian).
3. Akhtyamov S.N., Butov Yu.S. Practical dermatocosmetology. Moscow: Meditsina; 2003 (in Russian).
4. Bezuglyy A.P. Advanced techniques in cosmetology physiotherapy. In: Proceedings of the IV International Conference "Modern technologies of regenerative medicine (diagnostics, recovery, rehabilitation)". Sochi; 2001: 62-67 (in Russian).
5. Barinov É.F., Aĭziatulov R.F., Barinova M.É., Sulaeva O.N. Functional morphology of the skin: from fundamentals of histology to the problems of dermatology. Klinicheskaya dermatologiya i venerologiya 2012; 10(1):90-93 (in Russian).
6. Bozo I.J., Deev R.V., Pinaev G.P. Is «fibroblast» a specialized cell or a functional condition of mesenchymal cells derivatives? Tsitologiya 2010; 52(2):99-109 (in Russian).
7. Getling Z.M.. Ultrastructural studies of the dermis. Esteticheskaya meditsina 2002; 1(4):315-322 (in Russian).
8. Zorina A.I., Bozo I.Ya., Zorin V.L., Cherkasov V.R., Deev R.V. Derma fibroblasts: peculiarities of cytogenesis, histophysiology and possible clinical use. Cellular Transplantation and Tissue Engineering 2011; VI(2):15-26 (in Russian).
9. Margolina A. Stress as a cosmetic problem. Part 2: Stress and skin. Kosmetika & meditsina 2000; 2:42-52 (in Russian).
10. Manturova N.E., Gorodilov R.V., Kononov A.V. Skin ageing: mechanism of development and structural changes. Annaly plasticheskoy, rekonstruktivnoy i esteticheskoy khirurgii 2010; 1:88-92 (in Russian).
11. Myadelets O.D., Adaskevich V.P. Morphofunctional dermatology. Moscow: Meditsinskaya literatura; 2006 (in Russian).
12. Maliuk E.A., Tseluyko S.S., Krasavina N.P. Morphofunctional characteristic skin limbs of rats in a latent period when local cooling on the background of Dihydroquercetin. In: Proceedings of the International Conference "Issues of fundamental and applied science". Moscow; 2015: 23-30 (in Russian).
13. Maliuk E.A., Tseluyko S.S., Krasavina N.P. Structural changes in the limbs skin in rats at local cold exposure during treatment with antioxidants. Dal´nevostochnyy meditsinskiy zhurnal 2015; 2:101-105 (in Russian).
14. Omelʹyanenko N.P. Slutskiy L.I. Connective tissue (cytophysiology and biochemistry). Pt.1. Moscow: Izvestiya; 2009 (in Russian).
15. Orekhova E.M., Vasilieva E.S.. General Biological Processes of Functional Changes in Skin Aging. Novye meditsinskie tekhnologii. Novoe meditsinskoe oborudovanie 2010; 11:22-28 (in Russian).
16. Smirnova I.O., Kvetnoy I.M., Knyazkin I.V., Danilov S.I. Neuro-immuno-endocrinology of skin and molecular markers of aging. St. Petersburg: DEAN; 2005 (in Russian).
17. Tikhonova I.V., Tankanag A.V., Kosyakova N.I., Chemeris N.K., Age features of the functioning of the microvasculature of human skin. Rossiyskiy fiziologicheskiy zhurnal imeni I.M.Sechenova 2005; 91(10):1132-1137 (in Russian).
18. Shuginina E.A.. Aging of skin as a reflection of general biological aging process. In: Proceedings of the International Conference "Problematic issues of Plastic and Reconstructive Surgery". Moscow; 2004: 247-248 (in Russian).
19. Amagai M.. Desmoglein as a target in autoimmunity and infection. J. Am. Acad. Dermatol. 2003; 48(2):244-252.
20. Baumann L., Weinkle S. Improving elasticity: the science of aging skin. Cosmet. Dermatol. 2007; 20:168-172.
21. Baumann L. Cosmetic dermatology: Principles and Practice. New York: McGraw-Hill Medical; 2002.
22. Doljanski F. The sculpturing role of fibroblast-like cells in morphogenesis. Perspect. Biol. Med. 2004; 47(3):339-356.
23. El-Domyati M., Attia S., Saleh F., Brown D., Birk D.E., Gasparro F., Ahmad H., Uitto J. Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp. Dermatol. 2002; 11(5):398-405.
24. Feingold K.R. Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis. J. Lipid Res. 2007; 48(12):2531-2546.
25. Jakob T., Ring J., Udey M.C. Multistep navigation of Langerhans/dendritic cells in and out of the skin. J. Allergy Clin. Immunol. 2001; 108(5):688−696.
26. Kalinin A., Marekov L.N., Steinert P.M. Assembly of the epidermal cornified cell envelope. J. Cell Sci. 2001; 114(Pt.17):3069-3070.
27. Lahmann C., Bergemann J., Harrison G., Young A.R. Matrix metalloproteinase-1 and skin ageing in smokers. Lancet 2001; 357(9260):935-936.
28. Scharffetter-Kochanek K., Brenneisen P., Wenk J., Herrmann G., Ma W., Kuhr L., Meewes C., Wlaschek M. Photoaging of the skin from phenotype to mechanisms. Exp. Gerontol. 2000; 35(3):307-316.
29. Yaar M., Gilchrest B.A. Skin aging: postulated mechanisms and consequent changes in structure and function. Clin. Geriatr. Med. 2001; 17(4):617−630.
30. Zhuang L., Wang B., Shinder G.A., Shivji G.M., Mak T.W., Sauder D.N. TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation. J. Immunol. 1999; 162(3):1440 -1447.
31. Zouboulis C.C., Baron J.M., Böhm M., Kippenberger S., Kurzen H., Reichrath J., Thielitz A. Frontiers in sebaceous gland biology and pathology. Exp. Dermatol. 2008; 17(6):542-551.
