Tula, Tula, Russian Federation
UDC 61
Hematological malignant neoplasms are a group of diseases characterized by the complexity of diagnosis, which requires the doctor to know clinical and laboratory indicators. The case of acute myeloid leukemia in a 78-year-old patient is presented. The diagnosis was made in the therapeutic department within 14 days, and a sternal puncture, myelogram evaluation, cytochemical examination, and immunophenotyping allowed for a reliable diagnosis of the M4 variant. The patient's age and concomitant diseases were identified as unfavorable prognostic factors. The patient's leukemia was treated with the LDAraC (cytarabine) regimen, which had a positive but short-lived effect.
acute leukemia, myeloid leukemia, agranulocytosis, anemia, thrombocytopenia, cytarabine.
1. Klinika, diagnostika i lechenie zabolevaniy vnutrennih organov: uchebnoe posobie dlya podgotovki k prakticheskim zanyatiyam studentov 5 kursa lechebnogo fakul'teta po discipline «Gospital'naya terapiya»/Pod red. prof. L.I. Knyazevoy. – Kursk: KGMU, 2018. – 484 s.
2. Baranova O.Yu., Shirin A.D. Sovremennyy vzglyad na patogenez, diagnostiku i lechenie otdel'nyh redkih variantov ostryh leykozov // Klinicheskaya onkogematologiya. - 2022; 15(4). - S. 307-326. DOI:https://doi.org/10.21320/2500-2139-2022-15-4-307-326.
3. Atabaeva A. K., Hismetova Z. A., Nurahmetova Zh. B. Epidemiologiya novoobrazovaniy sistemy krovi. Obzor literatury // Nauka i zdravoohranenie. - 2021. - №6. - S.188-197.
4. Tolstyh T.N., Misyurina E.N., Mingalimov M.A. i dr. Effektivnost' lecheniya pacientov s ostrym mieloidnym leykozom po dannym moskovskogo onkologicheskogo registra v period s 2019 po 2023 g. // Onkogematologiya. - 2024;19(3). – C. 99–111. DOI: https://doi.org/10.17650/1818-8346-2024-19-3-99-111
5. Vinogradov A. V., Rezaykin A. V., Sazonov S. V., Schetinin E. V., Bobryshev D. V., Sergeev A. G. Issledovanie vozrastnoy dinamiki geneticheskih i morfologicheskih variantov ostryh mieloidnyh leykozov // Medicinskiy vestnik Severnogo Kavkaza. – 2022. - №17(4). - S. 357-360. DOI – https://doi.org/10.14300/mnnc.2022.1708.
6. Gindina T. L., Smirnova A. G., Bondarenko S. N. Ostryy mieloidnyy leykoz (lekciya) // Vestnik gematologii. - 2023. - №2. - S.54-67. URL: https://cyberleninka.ru/article/n/ostryy-mieloidnyy-leykoz-lektsiya.
7. Uchebnik po gematologii / N.I. Stuklov, G.I. Kozinec, N.G. Tyurina. — M.: Prakticheskaya medicina, 2018. – 336 str.
8. Egamova, S. K. Epigeneticheskie markery ostrogo mieloidnogo leykoza // Buharskiy gosudarstvennyy medicinskiy institut, Buhara, Uzbekistan. -2024. - №2. - S. 169-174.
9. Kurkova A. A., Grigor'eva A. I. Differencial'naya diagnostika ostrogo limfoblastnogo i ostrogo mieloblastnogo leykozov // Smolenskiy medicinskiy al'manah. - 2018. - №1. – S. 193-197.URL: https://cyberleninka.ru/article/n/differentsialnaya-diagnostika-ostrogo-limfoblastnogo-i-ostrogo-mieloblastnogo-leykozov.
10. Klinicheskie rekomendacii. Ostrye mieloidnye leykozy. Obscherossiyskiy nacional'nyy soyuz "Associaciya onkologov Rossii". God utverzhdeniya: 2020 g. Vozrastnaya gruppa: vzroslye. Utverzhdeny: Obscherossiyskiy nacional'nyy soyuz "Associaciya onkologov Rossii». S.95.
11. Zlokachestvennye novoobrazovaniya v Rossii v 2020 godu (zabolevaemost' i smertnost'). Pod red. A.D. Kaprina, V.V. Starinskogo, A.O. Shahzadovoy. M.: MNIOI im. P.A. Gercena – filial FGBU «NMIC radiologii» Minzdrava Rossii, 2021. 252 s.
12. Döhner H., Wei A., Appelbaum F. et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood 2022;140(12):1345–77.DOI:https://doi.org/10.1182/blood.202201686.
13. Shallis R.M. et al. Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. // Blood Rev. 2019. Vol. 36. P. 70–87.
14. Osnovy vnutrenney mediciny. V 2 t. T. 2 / Red. V.S. Moiseev, Zh.D. Kobalava, I.V. Maev, A.D. Kaprin,E.I. Gusev, M.V. Shestakova, S.V. Moiseev. — [2-e izd., pererab. i dop.] — Moskva : OOO «Medicinskoe informacionnoe agentstvo», 2020. — 724 s.
15. Mirzaahmedova I. Z. Kachestvo zhizni bol'nyh ostrymi leykozami// Ekonomika i socium. 2021. №4-2 (83). – S.201-204. URL: https://cyberleninka.ru/article/n/kachestvo-zhizni-bolnyh-ostrymi-leykozami.



