Angarsk, Irkutsk region, Russian Federation
The article describes the comparative study of the effect of lead intoxication in healthy animals and in terms of mod-elled hyperlipidemic condition on lipid metabolism, ECG performance, behavior in the test of the extrapolation of deliverance. The study was performed on 40 albino outbred adult male rats. Modeling hyperlipidemic condition was carried out daily by feeding natural unsalted fat at the rate of 8 grams per animal for 16 days. Lead intoxication was created after the atherogenic diet by adding lead acetate into drinking water in a dose of 50mg/kg of body weight for 4weeks. To investigate the lipid metabolism was measured in serum total cholesterol, triglycerides, HDL choles-terol, LDL cholesterol. In the test of extrapolation deliverance 70% of animals with lead intoxication on the lipid load background did not cope with the task versus 40% of albino rats in the group with lead acetate exposure alone. All control animals successfully solved the problem of the deliverance test. The deterioration of the functioning of the car-diovascular system of rats with lead poisoning on the background of atherogenic diet was manifested by elongation of intraventricular conduction intervals on an electrocardiogram as compared with animals with lead intoxication alone. Disorders of lipid metabolism were manifested by increased levels of LDL cholesterol in rats with lead intoxication on the background of hyperlipidemia to 0.86 (0.69–1.14)mmol/l compared with the value of 0.67(0.58–0.79)mmol/l in animals with lead intoxication.
lead, hyperlipidemia, electrocardiography, behavior, rats
1. BarsukovAP, AntonovAR (2007). Features of lipid profile and body mass indices of adult population in the territory of compact residence of indigenous inhab-itants of the Republic of Sakha (Yakutia) [Osobennosti lipidnogo profilya i pokazateley massy tela vzroslogo naseleniya na territorii kompaktnogo prozhivaniya ko-rennykh zhiteley respubliki Sakha (Yakutiya)]. Aktual’nye voprosy zdravookhraneniya regionov Sibiri: materialy nauchno-prakticheskoy konferentsii molodykh uchenykh, (6), 251-253.
2. VerichGE (1984). Effect of acetic lead on the systemic arterial pressure and ECG values [Vliyanie uksusnokislogo svintsa na sistemnoe arterial’noe davlenie i pokazateli EKG]. Vrachebnoe delo, (5), 112-114.
3. KoshkinaVS, KotlyarNN, KotelnikovaLV, Dol-gushinaNA (2013). Clinical and toxicological character-istics of plumbum and its compounds [Kliniko-toksiko-logicheskaya kharakteristika svintsa i ego soedineniy]. Meditsinskie novosti, (1), 20-25.
4. KulkybaevGA, NamazbaevaZI, MukashevaMA(2005). The principle of hygienic assessment of the urban environment in the environmental and health monitoring system (review of literature) [Printsip gigienicheskoy otsenki gorodskoy sredy v sisteme ekologo-gigieniches-kogo monitoringa (obzor literatury)]. Zdorov’e i bolezn’, (9), 4-8.
5. MartinM (2012). Guidelines on electrocardiography of small animals [Rukovodstvo po elektrokardiografii melkikh domashnikh zhivotnykh], 144.
6. On the state and protection of the environment in the Russian Federation in 2014. State report (2015) [O sostoyanii i ob okhrane okruzhayushchey sredy Rossiys-koy Federatsii v 2014 godu: Gosudarstvennyy doklad].
7. RevichBA (2001). On the peculiarities of ecological and epidemiological study of specific environment-related changes in health status of the population [Ob osoben-nostyakh ekologo-epidemiologicheskogo izucheniya spetsificheskikh ekologicheski obuslovlennykh izmeneniy sostoyaniya zdorov’ya naseleniya]. Gigiena i sanitariya, (5), 49-53
8. GaretsVI, FedchenkoNP, KonchaLI (1995). Method of atherosclerosis modelling: Patent 2033646 of the Russian Federation [Sposob modelirovaniya ateroskleroza: Patent No 2033646 Ros. Federatsiya].
9. TitovVN (1999). Commonability of atherosclero-sis and inflammation: specificity of atherosclerosis as an inflammatory process (hypothesis) [Obshchnost’ ateroskleroza i vospaleniya: spetsifichnost’ ateroskleroza kak vospalitel’nogo protsessa (gipoteza)]. Rossiyskiy kar-diologicheskiy zhurnal, (5), 48-56.
10. ShprakhVV, SayutinaSB, RomazinaTA, Mikha-levichIM (2011). Predicting the development of cognitive disorders in patients with combined atherosclerosis of cerebral and coronary arteries [Prognozirovanie razv-itiya kognitivnykh narusheniy u bol’nykh sochetannym aterosklerozom tserebral’nykh i koronarnykh arteriy]. Sibirskiy meditsinskiy zhurnal, (6), 57-59
11. WHO (2007). Level of lead in children’s blood.
