Irkutsk Scientific Center SB RAS (otdel mediko-biologicheskih issledovaniy i tehnologiy, starshiy nauchnyy sotrudnik)
Irkutsk State University (docent)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk State University (docent)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk Scientific Center SB RAS (otdel mediko-biologicheskih issledovaniy i tehnologiy, glavnyy nauchnyy sotrudnik)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk Scientific Center SB RAS (otdel mediko-biologicheskih issledovaniy i tehnologiy, zaveduyuschiy)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk State University (professor)
Irkutsk, Irkutsk region, Russian Federation
Izucheny vozmozhnosti lazernoy konfokal'noy mikroskopii v analize ob'ema lipidnyh chastic i kolichestva funkcional'no-aktivnyh mitohondriy i produkcii aktivnyh form kisloroda v kletkah pecheni dlya ranney diagnostiki citohimicheskih narusheniy pri dislipoproteidemii. Ocenen potencial analiza urovnya mtDNK plazmy krovi na rannih srokah razvitiya dislipoproteidemii i pri eksperimental'nom infarkte miokarda. Poluchennye dannye budut sluzhit' osnovoy dlya sozdaniya tehnologiy diagnosticheskogo monitoringa vyrazhennosti ateroskleroza i infarkta miokarda.
dislipoproteidemiya, ateroskleroz, infarkt miokarda, mitohondrii, aktivnye formy kisloroda, lipidnye chasticy, mitohondrial'naya DNK, molekulyarnye patterny riska
1. Sudakov NP, Popkova TP, Katyshev AI, Goldberg OA, Novikova MA, Ezhikeyeva SD, Ten MN, Nikiforov SB, Pushkaryov BG, Klimenkov IV, Lepekhova SA, Konstantinov YM (2011). Level of free-cell blood mitochondrial DNA in dyslipoproteinemia and adrenaline-caused myocarditis (experimental study) [Uroven’ svobodno tsirkuliruyushchey mitokhondrial’noy DNK krovi pri dislipoproteidemii i adrenalinovom miokardite (eksperimental’noe issledovanie)]. Izvestiya Irkutskogo Gosudarstvennogo universiteta. Seriya “Biologiya. Ekologiya”, 4 (4), 136-142.
2. Sudakov NP, Nikiforov SB, Konstantinov YM, Yakubov LA, Novikova NA, Karamysheva AN (2006). Mechanisms of mitochondria participation in pathological processes associated with ischemia and reperfusion [Mekhanizmy uchastiya mitokhondriy v razvitii patologicheskikh protsessov, soprovozhdayushchikhsya ishemiey i reperfuziey], Bulleten’ Vostocno-Sibirskogo naucnogo centra, (5), 332-336.
3. Chiu RW, Chan LY, Lam NY, Tsui NB, Ng EK, Rainer TH, Lo YM (2003). Quantitative analysis of circulating mitochondrial DNA in plasma. Clin. Chem., (49), 719-726.
4. Ellinger J, Müller SC, Wernert N, von Ruecker A, Bastian PJ (2008). Mitochondrial DNA in serum of patients with prostate cancer: a predictor of biochemical recurrence after prostatectomy. BJU Int., (102), 628-632.
5. Herms A, Bosch M, Ariotti N, Reddy BJ, Fajardo A, Fernández-Vidal A, Alvarez-Guaita A, Fernández-Rojo MA, Rentero C, Tebar F, Enrich C, Geli MI, Parton RG, Gross SP, Pol A (2013). Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity. Curr. Biol., (23), 1489-1496.
6. Ricci F, De Caterina R (2011). Isolated creatine kinase-MB rise with normal cardiac troponins: a strange occurrence with difficult interpretation. J. Cardiovasc. Med., (12), 736-740.
7. Sudakov NP, Popkova TP, Novikova MA, Katyshev AI, Nikiforov SB, Pushkarev BG, Goldberg AO, Klimenkov IV, Lepekhova SA, Ezhikeeva SD, Ten MN, Osipov VG, Konstantinov YM (2012). The level of blood plasma mitochondrial DNA upon acute myocardium damage in experiment. Biopolymers and Cell, 28 (4), 321-324.
8. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ (2010). Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature, (464), 104-107.
