PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION
Rubrics: PEDIATRICS
Authors:
1.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Pediatrics and Neurophysiology, Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
2.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Pediatrics and Neurophysiology, Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(laboratoriya personalizirovannoy mediciny, rukovoditel')
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
4.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Pediatrics and Neurophysiology, Leading Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
5.
Scientific Centre for Family Health and Human Reproduction Problems
(Deputy Director for Clinical Work)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
6.
Nauchnyy centr problem zdorov'ya sem'i i reprodukcii cheloveka
(laboratoriya fiziologii i patologii endokrinnoy sistemy, starshiy nauchnyy sotrudnik)
Irkutsk State Medical Academy of Postgraduate Education (Department of Pedagogical and Information Technologies, Head)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk State Medical Academy of Postgraduate Education (Department of Pedagogical and Information Technologies, Head)
Irkutsk, Irkutsk region, Russian Federation
7.
Scientific Centre for Family Health and Human Reproduction Problems
(direktor)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 58
to 62
Status:
Published
Received:
01.11.2017
Accepted:
02.11.2017
Published:
02.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
podrostki, geny, essencial'naya arterial'naya gipertenziya, protromboticheskie izmeneniya, tromboz
Abstract (English):
Serdechno-sosudistye zabolevaniya (SSZ) ostayutsya vazhneyshey prichinoy smertnosti vo vsem mire. Naibolee rasprostranennym SSZ yavlyaetsya essencial'naya arterial'naya gipertenziya (EAG), rost zabolevaemosti kotoroy otmechaetsya sredi detey, osobenno sredi podrostkov. Issledovaniya po izucheniyu narusheniy v sisteme gemostaza u bol'nyh s EAG svidetel'stvuyut o vozmozhnosti formirovaniya protromboticheskih izmeneniy (PTI). Odnako problema ranney diagnostiki PTI u podrostkov s EAG yavlyaetsya na segodnyashniy den' aktual'noy i trebuyuschey vnimaniya pediatrov. Cel' issledovaniya – razrabotat' prognosticheskie kriterii riska vozniknoveniya PTI u podrostkov s EAG dlya svoevremennogo provedeniya profilakticheskih meropriyatiy i preduprezhdeniya razvitiya tromboticheskih oslozhneniy. Obsledovano 37 podrostkov s EAG i PTI i 60 – s EAG, v vozraste 14–17 let, prozhivayuschih na territorii Vostochnoy Sibiri, u kotoryh izuchali osobennosti genealogicheskogo anamneza, pokazateley sutochnogo monitorirovaniya urovnya arterial'nogo davleniya (SMAD), koagulyacionnye narusheniya sistemy gemostaza i strukturu polimorfizmov genov predraspolozhennosti k trombozam po dannym kliniko-anamnesticheskogo, funkcional'nogo i laboratornogo issledovaniy. Kontrol'nuyu vyborku sostavili zdorovye podrostki, sopostavimye po polu i vozrastu s pacientami klinicheskih grupp. V rezul'tate provedennogo issledovaniya sozdana model' prognozirovaniya riska razvitiya PTI, pozvolyayuschaya s tochnost'yu 86,18 % vyyavlyat' trombogennyy risk v podrostkovom vozraste u lic s EAG po opredelennym priznakam (polimorfizm S677T gena MTHFR, polimorfizm A66G gena MTRR, DADd, SADn, IV gipertenzii SADd, otyagoschennyy tromboticheskiy genealogicheskiy anamnez, rannee nastuplenie trombozov, IO tromboticheskogo anamneza) i svoevremenno nachat' provedenie profilakticheskih meropriyatiy s cel'yu snizheniya chastoty tromboticheskih oslozhneniy EAG i smertnosti bol'nyh.
Serdechno-sosudistye zabolevaniya (SSZ) ostayutsya vazhneyshey prichinoy smertnosti vo vsem mire. Naibolee rasprostranennym SSZ yavlyaetsya essencial'naya arterial'naya gipertenziya (EAG), rost zabolevaemosti kotoroy otmechaetsya sredi detey, osobenno sredi podrostkov. Issledovaniya po izucheniyu narusheniy v sisteme gemostaza u bol'nyh s EAG svidetel'stvuyut o vozmozhnosti formirovaniya protromboticheskih izmeneniy (PTI). Odnako problema ranney diagnostiki PTI u podrostkov s EAG yavlyaetsya na segodnyashniy den' aktual'noy i trebuyuschey vnimaniya pediatrov. Cel' issledovaniya – razrabotat' prognosticheskie kriterii riska vozniknoveniya PTI u podrostkov s EAG dlya svoevremennogo provedeniya profilakticheskih meropriyatiy i preduprezhdeniya razvitiya tromboticheskih oslozhneniy. Obsledovano 37 podrostkov s EAG i PTI i 60 – s EAG, v vozraste 14–17 let, prozhivayuschih na territorii Vostochnoy Sibiri, u kotoryh izuchali osobennosti genealogicheskogo anamneza, pokazateley sutochnogo monitorirovaniya urovnya arterial'nogo davleniya (SMAD), koagulyacionnye narusheniya sistemy gemostaza i strukturu polimorfizmov genov predraspolozhennosti k trombozam po dannym kliniko-anamnesticheskogo, funkcional'nogo i laboratornogo issledovaniy. Kontrol'nuyu vyborku sostavili zdorovye podrostki, sopostavimye po polu i vozrastu s pacientami klinicheskih grupp. V rezul'tate provedennogo issledovaniya sozdana model' prognozirovaniya riska razvitiya PTI, pozvolyayuschaya s tochnost'yu 86,18 % vyyavlyat' trombogennyy risk v podrostkovom vozraste u lic s EAG po opredelennym priznakam (polimorfizm S677T gena MTHFR, polimorfizm A66G gena MTRR, DADd, SADn, IV gipertenzii SADd, otyagoschennyy tromboticheskiy genealogicheskiy anamnez, rannee nastuplenie trombozov, IO tromboticheskogo anamneza) i svoevremenno nachat' provedenie profilakticheskih meropriyatiy s cel'yu snizheniya chastoty tromboticheskih oslozhneniy EAG i smertnosti bol'nyh.
Keywords:
podrostki, geny, essencial'naya arterial'naya gipertenziya, protromboticheskie izmeneniya, tromboz
podrostki, geny, essencial'naya arterial'naya gipertenziya, protromboticheskie izmeneniya, tromboz
1. Spislit podrostki s essencial'noy ag
