The paper presents the results of study of the antibacterial effect of silver nanoparticles when ingested, on the experimental model of peritonitis and meningoencephalitis in vivo. In conditions of the increasing resistance of bacteria to antibacterial drags, the search of alternative means which will allow to effectively deal with clinically significant microorganisms, is relevant. Such tools are the nanoparticles of metals, particularly the silver nanoparticles. According to results of conducted research, they show quite a high antibacterial and antiviolence activity. The study prove that at intra-cerebral introduction of pathogenic strains of microorganisms (experimental meningoencephalitis), after per oral use of nanosilver - effect didn´t observed; in the group of animals with intra-peritoneal injection (experimental peritonitis) - the signs of inflammation of the peritoneum by microscopic examination didn´t revealed.
silver nanoparticles, biofilms, antibacterial effect, antibiotics, peritonitis, meningoencephalitis, bioaccumulation
В последние годы наночастицы серебра (AgNPs) успешно используются в медицине для доставки терапевтических агентов [3]. Они считаются менее токсичными, чем ионы серебра. Исследования показали, что AgNPs влияет на бактериальную проницаемость мембран и прикрепление бактерий к поверхности клеточной мембраны. Обнаружение в больших количествах наночастиц внутри бактерий предполагает, что это важнейший антибактериальный механизм. Кроме того, AgNPs взаимодействует с бактериальными мембранными белками, внутриклеточными белками, фосфатными остатками в ДНК, и вмешивается в деление клеток, что приводит к гибели бактериальной клетки [4, 5]. В фокусе научного анализа оказались биопленки, как особая и, тем не менее, абсолютно превалирующая форма существования микроорганизмов при инфекционных заболеваниях человека. Формируется новая ветвь профилактической и терапевтической медицины, нуждающаяся в разработке фармацевтических и нефармацевтических методов предупреждения образования биопленок или разрушения образовавшихся [1,2].
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