The paper contains information about the mechanisms of therapeutic action of hyperbaric oxy-genation on oxygen regime and state functions of brain cortex and stem during acute cerebral ischemia of 90 minutes length and on renal cortex during acute serum glomeralonephritis. Experimental acute cerebral ischemia is simulated by deligation of both common carotid arteries which leads to subcompensated and decompensated forms of ischemia. Experimental acute serum glomeralonephritis is simulated by a single intravenous injection of bovine serum albumin. A single session of hyperbaric oxygenation is carried out within 60 minutes (3 absolute atmospheres mode) at the first day of the pathological process formation. The following factors are analyzed: motion activity, electrical activity of brain and heart, volume rate of cerebral blood flow, blood pH, oxygen tension in the arterial and venous blood, arteriovenous oxygen and oxyhemoglobin difference, oxygen consumption by brain tissue in the end of 90 minutes of cerebral ischemia in conditions of hyperoxia. Volumetric blood flow rate, oxygen tension in renal cortex are measured; condition of renal ultrafiltration in early and late post hyperoxia periods during acute serum glomeralonephritis is defined. This paper shows a positive effect which hyperoxia has on the functional and metabolic processes at tissue and cellular level in the brain suffered from ischemia and kidneys during acute serum glomeralonephritis. Hyperbaric oxygenation restores blood flow and oxygen regime in the brain cortex and stem and renal cortex, normalizes metabolic processes in the brain cells and restore renal function.
hyperoxia, hyperbaric oxygenation, blood flow, oxygen, glomeralonephritis, cerebral ischemia, adaptation
Эволюционные программы адаптации охватывают все уровни саморегуляции высших организмов. В эволюционном периоде биосферы с пониженным давлением кислорода сформировалась генетическая программа адаптации к гипоксии, а с повышением напряжения кислорода - программа адаптационных реакций на гипероксию. Живые организмы сформировали стереотипные реакции адаптации - биоэнергетики, деток-сикации и биосинтеза на недостаток или избыток кислорода. При резко выраженной кислородной недостаточности приспособительные реакции организма могут оказаться недостаточными. Возникающий дефицит кислорода в тканях головного мозга, приводит к нарушению жизнедеятельности нервных клеток и клеток других органов и развитию ряда серьезных заболеваний [1, 8]. Распространенность заболеваний, сопровождающихся ишемией головного мозга, почек велика: от незначительных нарушений функций до терминальных состояний, вызванных экстремальными факторами [2].
1. Leonov AN. Giperoksiya: Adaptatsiya. Sanogenez. Voronezh; 2006. Russian.
2. Mal´tseva LD, Bolotskikh VI. Rol´ elektrolitnykh narasheniy v mekhanizmakh razvitiya ishemii golovnogo mozga [The role of electrolyte imbalance in the cerebral ischemia pathogenic mechanisms]. Vestnik novykh meditsinskikh tekhnologiy. 2011;18(2):135-7. Russian.
3. Lou M, Eschenfelder CC, Herdegen T, Brecht S, Deuschl G. Therapeutic window for use of hyperbaric oxygenation in focal transient ischemia in rats. Stroke. 2004;35:578-83.
4. Kolomeets NYu, Aver´yanova NI, Zarnitsyna NYu, Kosareva PV. Eksperimental´nyy ostryy poststreptokokkovyy glomerulonefrit. Fundamental´nye issledovaniya. 2010;6:49-53. Russian.
5. Mal´tseva LD. Izmenenie elektrolitnogo obmena kak sanogeneticheskiy effekt giperoksii pri ishemii go-lovnogo mozga [Changes in electrolyte metabolism as to sanogenetic effect of hyperoxia during cerebral ischemia]. Vestnik novykh meditsinskikh tekhnologiy. 2011;18(2):37-40. Russian.
6. Xing B, Chen H, Zhang M. Ischemic post conditioning inhibits apoptosis after focal cerebral ischemia reperfusion injury in the rat. Stroke. 2008;39(8):2362-9.
7. Ayus J, Achinger S, Arieff A. Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia. Am J Physiol Renal Physiol. 2008;295:619-24.
8. Es´kov VM, Mishina EA, Tatarnikov VS, Khadartseva KA. Gipoksiya i regulyatsiya dykhaniya s pozi-tsiy teorii khaosa i sinergetiki [Hypoxia and breath regulation according the theory of chaos and synergetic]. Vestnik novykh meditsinskikh tekhnologiy. 2008;15(2):29-33. Russian.
9. Dzasokhov AS. Perspektivy primeneniya Giperbaricheskoy oksigenatsii pri lechenii raka endometriya [Prospects of the use of hyperbaric oxygen in the treatment of endometrial cancer]. Vestnik novykh meditsinskikh tekhnologiy (elektronnyy zhurnal) [Internet]. 2013 [cited 2013 oct 15];1:[about 3 p.] Russian. Available from: http://www.medtsu. tula.ru/VNMT/Bulletin/E2013-1/4512.pdf
10. Dzasokhov AS. Sravnitel´naya kharakteristika effektivnosti metodov oksigenoterapii pri kombinirovannom lechenii raka yaichnikov [Comparative characteristics of efficiency of oxygenotherapy methods at combined treatment of ovarian cancer]. Vestnik novykh meditsinskikh tekhnologiy (elektronnyy zhurnal). [Internet]. 2013 [cited 2013 Jul 30]; 1:[about 4 p.] Russian. Available from: http://www.medtsu.tula.ru/VNMT/Bulletin/E2013-1/4467.pdf
11. Khadartsev AA, Gerashchenko MA, Savkova RF, Yudina LF, Dzasokhov AS. Obosnovanie primeneniya giperbaricheskoy i normobaricheskoy oksigenatsii v onkoginekologii. I Mezhdunarodnaya nauchno-prakticheskaya konferentsiya «Innovatsionnye tekhnologii upravleniya zdorov´em i dolgoletiem cheloveka» (Sankt-Peterburg, 8-9 aprelya 2010 g.). SPb.; 2010. Russian.
