Purpose of the investigation is to develop and introduce the methods of prognosis complications of oral sanitation at the treatment of the patients with locally common cancer of oral mucosa. Sanitation of oral cavity in patients with locally common cancer of oral mucus membrane is connected with development of various complications among which infections and hemorrhages play a leading part. It determines problem of development of methods of forecasting of these complications as relevant. Material and methods: Based on a comparative analysis of 340 patients with above pathology the authors have traced dependence between the development of complications in oral cavity after chemical and radial therapy and levels of lactoferrin (LF) in saliva. This simple and non-invasive method can be as a marker of pathological states in oral cavity. Among the complex of the parameters the authors have studied risk factors of complications after the use of the cytostatics and radial therapy with resulting index of prognosis (IP) for development of complications. Based on the index of prognosis individual tactics of treatment was determined. Results: Depending on the saliva levels of lactoferrin in patients receiving chemo- and radial therapy a complex of prophylactic and curable measures was developed, which allowed to decreasing the number of inflammatory processes in a zone of dental procedures from 14,1 to 2,8% and the number of bleedings from 8,0 to 5,0%. Conclusions. Level of LF in saliva can be considered as valid prognostic marker of the development of destructive complications while oral sanitation in patients received chemo- and radial therapy. Assessment of the probability of these complications with correction of preventive and therapeutic measures should be implemented depending on the prognostic value of the index. Prevention activities for development of complications in sanitation of oral cavity in cancer patients after combined and complex treatment can reduce the number of hemorrhagic complications to 5.0%, and the local inflammatory processes to 2.8%.
lactoferrin, sanitation, chemo- and radial therapy, locally common cancer of mucosa of oral cavity.
1. Davydov M.I., Aksel´ E.M. Zlokachestvennye novo-obrazovaniya v Rossii i stranakh SNG v 2002. M.: MMA, 2004. 254 s.
2. Khimioluchevoe lechenie bol´nykh s mestno-rasprostranennym rakom organov polosti rta i rotoglotki / Karaseva V.V. [i dr.]. «Rossiyskaya onkologiya». 2000. №4. S. 21-23.
3. Epidemiologiya raka slizistoy obolochki polosti rta i sostoyanie onkologicheskoy pomoshchi naseleniyu s dannoy patologiey v Rossiyskoy Federatsii / Podvyazni-kov S.O. [i dr.]. Materialy nauchn. konf. «Sovremennye metody diagnostiki i lecheniya raka slizistoy obolochki polosti rta», Samara - M., 2011. S. 42.
4. Late toxicities due to multimodal treatment of head and neck cancer (HNC) / Buentzel J. [et al]. Radiotherapy and oncology. 2004. Vol. 73(1). P. 716.
5. Effects of lapatinibmonotherapy: result of a randomized phase II study in therapy- naive patients with locally advanced squamous cell carcinoma of the head and neck / Del Campo J.M. [et al]. Br. J. Cancer. 2011. Vol.105(5). P.618-627.
6. Treatment results of postoperative radiotherapy on squamous cell carcinoma of the oral cavity: coexistence of multiple minor risk factors results in higher rates / Fan E.I. [et al]. Int. J. Radiat. Oncol. Biol. Phys. 2010. Vol. 77(4). P.1024-1029.
7. Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy vs accelerated hyperfractionated radiotherapy vs concomitant radiotherapy and chemotherapy - a multicenter randomized trial. Update at 5 years / Falli C. [et al]. Radiotherapy and oncology. 2004. Vol.73(1). P. 676.
8. Phase II trial of induction chemotherapy followed by surgery for squamous cell carcinoma of the oral tongue in young adults / Kies M.S. [et al]. Head Neck. 2012. Vol. 34(9). P. 1255-1262.
9. Preoperative concurrent chemoradiotherapy for stages II-IV oral squamous cell carcinoma: a retrospective analysis and future possibility of this treatment strategy / Kirita T. [et al]// Int. J. Oral Maxillofac. Surg. 2012. Vol. 41(4). P. 241-248.
10. Ord R.A. Surgical management of the N0 neck in early stage Tl-2 oral cancer; a personal perspective of early and impalpable disease. Oral Maxillofac. Surg. 2012. Vol.16(2). P. 181-188.
