Tomsk, Russian Federation
employee
Tomsk, Russian Federation
employee
Tomsk, Russian Federation
employee
Tomsk, Russian Federation
employee
National Research Tomsk Polytechnic University (Deputy Director)
employee
Tomsk, Russian Federation
This publication demonstrates the possibility of dynamic observation of a patient with a diagnosis of a malignant brain tumor at the stages of combined treatment using SPECT with a new radiopharmaceutical drug 99mTc-1-thio-D-glucose. Also in the described clinical case, an attempt was made to semi-quantitatively assess the accumulation of 99mTc-1-thio-D-glucose drug in the tumor, reflecting the dynamics of changes occurring in the tumor tissue under therapeutic effect. The SPECT data with 99mTc-1-thio-D-glucose in the course of dynamic observation of the patient were supported by the results of MRI and, most importantly, by PET data with 11C-methionine. Based on the results presented, it was suggested that a promising method would appear for evaluating the results of treatment of malignant brain tumors, which is an alternative to PET with labeled amino acids, which favorably differ in the availability and cost of the diagnostic procedure.
radiopharmaceutical, brain tumor, technetium-99m, labeled glucose
1. Weller M., van den Bent M., Tonn J.C., et al. European Association for Neuro-Oncology (EANO): Guideline on the Diagnosis and Treatment of Adult Astrocytic and Oligodendroglial Gliomas // Lancet Oncol. 2017. Vol. 18. P.315-329
2. Segtnan E.A., Hess S., Grupe P., et al. 18F-Fluorodeoxyglucose PET/Computed Tomography for Primary Brain Tumors // PET Clin. 2015. Vol. 10. P.59-73
3. Song P.J., Lu Q.Y., Li M.Y., et al. Comparison of Effects of 18F-FDG PET-CT and MRI in Identifying and Grading Gliomas // J. Biol. Regul. Homeost Agents. 2016. Vol. 30. P.838-848.
4. Chernov V.I., Medvedeva A.A., Sinilkin I.G., Zel'chan R.V., Bragina O.D., Skuridin V.S. Opyt razrabotki innovacionnyh radiofarmprepartov v Tomskom NII onkologii // Sibirskiy onkologicheskiy zhurnal. 2015. T.12. №2. S.45-47c.
5. Chernov V., Sinilkin I., Choynzonov E. Zelchan R.V., Bragina O.D., Skuridin V.S. Comparative Evaluation of 99mTs-Al2O3 and 99mTs-fitat Nanocolloids for Sentinel Lymph Nodes Visualization in Patients with Cancer of Larynx and Hypopharynx // Eur. J Nucl. Med. and Molec. Imaging. 2015. Vol. 42. №1. P.704-709.
6. Chernov V.I., Bragina O.D., Sinilkin I.G. i dr. Radionuklidnaya teranostika zlokachestvennyh obrazovaniy // Vestnik rentgeno-logii i radiologii, 2016. T.97, №.5. S.306-313.
7. Karunanithi S., Sharma P., Kumar A., et al. Can 18F-FDOPA PET/CT Predict Survival in Patients with Suspected Recurrent Glioma? A Prospective Study // Eur J Radiol. 2014. Vol. 83. P. 219-225.
8. Ullrich RT, Kracht L, Brunn A, et al. Methyl-L-11C-methionine PET as a Diagnostic Marker for malignant progression in Patients with Glioma // J Nucl Med. 2009. Vol. 50. P.1962-1968.
9. Glaudemans A.W., Enting R.H., Heesters M.A., et al. Value of 11C-methionine PET in Imaging Brain Tumours and Metastases // Eur J Nucl Med Mol Imaging. 2013. Vol. 40. P.615-35.
10. Chernov V.I., Bragina O.D., Sinilkin I.G. i dr. Radioimmuno-terapiya v lechenii zlokachestvennyh obrazovaniy // Sibirskiy onkolo-gicheskiy zhurnal, 2016. T.15, №.2. S.101-6
11. Zeltchan R., Medvedeva A., Sinilkin I. et al. Experimental Study of Radiopharmaceuticals Based on Technetium-99m Labeled Derivative of Glucose for Tumor Diagnosis // IOP Conference Series // Materials of Science and Engineering. «VIII International Scientific Conference «Issues of Physics and Technology in Science, Industry and Medicine». 2016. P. 012054.
12. Krylov A.S., Ryzhkov A.D., Shiryaev S.V. i dr. OFEKT/KT s 99mTc-tehnetrilom v diagnostike zlokachestvennyh opuholey golovy i shei u detey // Medicinskaya radiologiya i radiacionnaya bezopasnost'. 2020. T.65, №.1. S.27-36. DOI:https://doi.org/10.12737/1024-6177-2020-65-1-27-36.
13. Ryzhkov A.D., Yakovleva L.P., A.S. Krylov i dr. OFEKT/KT v posleoperacionnoy diagnostike funkcional'nogo sostoyaniya autotransplantatov chelyustno-licevoy oblasti // Medicinskaya radiologiya i radiacionnaya bezopasnost'. 2018. T.63, № 5. S. 26-32. DOI: 10.12737 /article_5bc8968bb9d9a3.36167944.
14. Krylov A.S., Shiryaev S.V., Ryzhkov A.D. i dr. OFEKT/RKT s 99mTc-tehnetrilom v monitoringe estezioneyroblastomy // Sibirskiy onkologicheskiy zhurnal. 2017. T.16, №.2. S.97-102. DOI: 10.21294 /1814-4861-2017-16-2-97-102
15. Zel'chan R.V., Medvedeva A.A., Bragina O.D. i dr. Izuchenie obschey ostroy toksichnosti novogo radiofarmpreparata 99mTc-1-tio-D-glyukoza v eksperimente // Molekulyarnaya medicina. 2019. T.9, №.1. S.58-66.
16. Zel'chan R.V., Medvedeva A.A., Sinilkin I.G. i dr. Izuchenie funkcional'noy prigodnosti tumorotropnogo radiofarm-preparata 99mTs-1-tio-D-glyukoza v eksperimente // Molekulyarnaya medicina. 2018. T.16, №3. S.54-7.
17. Zeltchan R., Medvedeva A., Sinilkin I., Chernov V., Stasyuk E., Rogov A., Skuridin V. Study of Potential Utility of New Radiopharmaceuticals Based on Technetium-99m Labeled Derivative of Glucose // Paper Presented at the AIP Conference Proceedings. 2016. P.1760. DOI:10.1063 /1.4960291
18. Chernov V.I., Bragina O.D., Sinilkin I.G., Medvedeva A.A., Zelchan R.V. Radioimmunotherapy: Current State of the Problem // Problems of Onkology. 2016. Vol. 62, №1. P.24-30.
