Russian Federation
CSCSTI 76.33
CSCSTI 76.03
Russian Classification of Professions by Education 31.06.2001
Russian Classification of Professions by Education 31.08.08
Russian Classification of Professions by Education 32.08.12
Russian Classification of Professions by Education 14.04.02
Russian Library and Bibliographic Classification 534
Russian Library and Bibliographic Classification 51
Russian Trade and Bibliographic Classification 5712
Russian Trade and Bibliographic Classification 5734
Russian Trade and Bibliographic Classification 6212
Russian Trade and Bibliographic Classification 5708
Purpose: Study of the influence of high-power pulses of coherent non-ionizing terahertz (THz) radiation on the formation of foci of double-strand DNA breaks and the proliferative activity of human neuronal cells. Material and methods: Irradiated cell cultures are direct reprogramming neural progenitor cells (drNPCs), neuroblastoma cells (SK-N-BE). Cells are irradiated with a sequence of THz radiation pulses with a peak intensity of ~ 20 GW/cm2 and electric field strength of 2.8 MV/cm. Irradiation lasts 30 mins. Results: There is no statistically significant difference in the number of γH2AX histone foci between experimental and control cell groups. Conclusion: It was shown that a short exposure (30 min) of cells to THz radiation with intensity of 20 GW/cm2 does not affect the proliferative activity of both neural progenitor cells and neuroblastoma cells and does not cause a significant increase in γH2AX foci in any of the studied cell lines.
non-ionizing radiation, terahertz radiation, H2AX histone foci, proliferative activity, neural stem cells, SK-N-BE neuroblastoma
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