Russian Federation
Tula, Tula, Russian Federation
The article is devoted to the problem of cardiotoxicity of chemotherapy drugs used in cancer patients, the nonspecificity of early clinical manifestations of cardiomyopathy developing against this background, and the search for informative diagnostic techniques to confirm this disease. As an illustration, a clinical case of cardiomyopathy in a young woman who developed against the background of chemotherapy for breast cancer is presented.
chemotherapy, cardiotoxicity, chronic heart failure, cardiomyopathy
1. Felker G. M. , Thompson R. E. , Hare J. M. , et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med, 342 (2000), pp. 1077-1084. http: //dx. doi. org/10. 1056/NEJM200004133421502
2. O'Hare M, Sharma A. , Murphy K. , et. al. Cardio-oncology Part I: chemotherapy and cardiovascular toxicity. Expert Rev Cardiovasc Ther. 2015 Apr 5: 1-8. http: //dx. doi. org/10. 1586/14779072. 2015. 1027686
3. Truong J, Yan A. T. ,Cramarossa G. et. al. Chemotherapy-induced cardiotoxicity: detection, prevention, and management. Can J Cardiol. 2014 Aug;30 (8): 869-78. doi: 10. 1016/j. cjca. 2014. 04. 029.
4. Cardinale, D. , Colombo, A. , Torrisi, R. , Sandri, M. T. , Civelli, M. , Salvatici, M. et al. Trastuzumab-induced cardiotoxicity: clinical and prognostic implications of troponin I evaluation. J Clin Oncol. 2010; 28: 3910-3916. doi: 10. 1200/JCO. 2009. 27. 3615.
5. Kardiomiopatii: uchebnik /pod red.Reznik E.V. - Moskva: Yurayt, 2021, 246 str.
6. DolciA. ,Dominici R. , Cardinale D. , Sandri M. T. et. al. Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: systematic review of the literature and recommendations for use. Am J Clin Pathol. 2008 Nov;130 (5): 688-95. doi: 10. 1309/AJCPB66LRIIVMQDR.
7. Golubcov O.Yu., Tyrenko V.V., Lyutov V.V., Maslyakov V.V., Makiev R.G. Kardiovaskulyarnye oslozhneniya protivoopuholevoy terapii// Sovremennye problemy nauki i obrazovaniya. - 2017. - № 2.
8. Huang C. , Zhang X. , Ramil J. M. , et al. Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation, 121 (2010), pp. 675-683. doi: 10. 1161/CIRCULATIONAHA. 109. 902221.
9. OretoL. , Todaro M. C. , Umland M. M. , Kramer C. et. al. Use of echocardiography to evaluate the cardiac effects of therapies used in cancer treatment: what do we know? J Am Soc Echocardiogr. 2012 Nov;25 (11): 1141-52. doi: 10. 1016/j. echo. 2012. 09. 001
10. Gudkova A.Ya. Kardiomiopatii. Nacional'noe Rukovodstvo «Kardiologiya» (kratkoe izdanie) pod red. akad. RAN E.V. Shlyahto. Izd. «Geotar», Moskva, 2018g-815 s.
