IMPORTANCE OF MICROBIOFILMS IN INFECTION PATHOLOGY OF HUMAN (REVIEW)
Abstract and keywords
Abstract (English):
This article deals with biofilms – a special form of existence of bacteria. We consider the stage of formation of biofilm, regulatory processes ("quorum sensing") occurring in biofilms. By the "effect of quorum" is a transfer of information in the following ways: contact between the cells of microorganisms, the synthesis of diffusing in the medium pheromone-like agents generating bacteria physical (and other electromagnetic) fields. According to the literature, well established role of biofilms at least 60% of all chronic or recurrent infections. Established, that the formation of biofilms clinically significant strains occur on endoprothesis catheters coated medical instruments, ventilators and other medical supplies. There is evidence that the results of experiments according to the most resistant biofilm in a medium capable of forming a gastric strain Helicobacter pylori TK 1402. Also discusses the role of microbial biofilm formation in acute and chronic infections of the ENT - organs. In addition, the results of experiments designed to combat the formation of biofilms.

Keywords:
biofilm matrix "quorum sensing", biocides, colonization.
References

1. Bondarenko V.M. Mekhanizmy formirovaniya patogennosti opportunisticheskimi mikroorga-nizmami. Materialy II Ezhegodnogo Vserossiyskogo kongressa po infektsionnym boleznyam. M., 2010. S. 42-43.

2. Bondarenko V.M. Rol´ uslovno-patogennykh bakteriy pri khronicheskikh vospalitel´nykh protses-sakh razlichnoy lokalizatsii. Tver´: Triada, 2011. 88 s.

3. Bekhalo V.A. Immunobiologicheskie osobennosti bakterial´nykh kletok, vkhodyashchikh v sostav «me-ditsinskikh bioplenok». Mikrobiologiya. 2010. № 4. S. 97-107.

4. Elinov N.P. Strukturirovannye i nestrukturirovannye formy sushchestvovaniya mikromitsetov v iskusstvennykh i estestvennykh usloviyakh. Problemy meditsinskoy mikologii. 2009. T. 11. № 3. S. 3-9.

5. Il´ina T.S. Bioplenki kak sposob sushchestvovaniya bakteriy v okruzhayushchey srede i organizme khozyaina: fenomen, geneticheskiy kontrol´ i sistemy regulyatsii ikh razvitiya. Genetika. 2004. № 40. S. 1-12.

6. Milenin D.O. Mikrobnaya bioplenka Helicobacter Pylori i ee rol´ v patogeneze yazvennoy bolezni zheludka i dvenadtsatiperstnoy kishki. Farmateka. 2010. №20. S. 20-24.

7. Chernyavskiy V.I. Bakterial´nye bioplenki i infektsii. Annals of Mechnikov Institute. 2013. №1. R. 86-90.

8. Khrenov P.A., Chestnova T.V. Obzor metodov bor´by s mikrobnymi bioplenkami pri vospali-tel´nykh zabolevaniyakh. Vestnik novykh meditsinskikh tekhnologiy. Elektronnoe izdanie. 2013. №1. Pub-likatsiya 2-13. URL: http://www.medtsu.tula.ru/VNMT/ Bulletin/E2013-1/4102.pdf (data obrashcheniya: 01.02.2013).

9. Khrenov P.A., Chestnova T.V. Effekt dimetilsul´foksida v otnoshenii bioplenkoobrazovaniya shtammami Staphylococcus aureus. Mezhdunarodnyy zhurnal prikladnykh i fundamental´nykh issledovaniy. 2014. № 5-1. S. 140-141.

10. Hall-Stoodley L. Evolving concepts in biofilm infections. Cell Microbiol. 2009. Vol. 11. N. 7. P. 1034-1043.

11. Donlan R.M. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin. Microbiol. Rev. 2002. Vol. 15. N. 2. P. 167-193.

12. Bester E. Metabolic differentiation in biofilms as indicated by carbon dioxide production rates. Appl. Environ. Microbiol. 2010. Vol. 76. N. 4. P. 1189-1197.

13. Guiot E. Heterogeneity of diffusion inside microbial biofilms determined by fluorescence correlation spectroscopy under two-photon excitation. Photochem. Photobiol. 2002. Vol. 75. N. 6. P. 570-579.

14. Dietrich L.E. The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa. Mol. Microbiol. 2006. Vol. 61. N. 5. P. 1308-1321.

15. Flemming H.C. The EPS matrix: the "house of biofilm cells". J. Bacteriol. 2007. Vol. 189. N. 22. P. 7945-7947.

16. Hibbing M.E. Bacterial competition: surviving and thriving in the microbial jungle. Nat. Rev. Mi-crobiol. 2010. Vol. 8. N. 1. P. 15-25.

17. Hurlow J. Clinical experience with wound biofilm and management: a case series. Ostomy Wound Manage. 2009. Vol. 55. N. 4. P. 38-49.

18. James G.A. Biofilms in chronic wounds. Wound Repair Regen. 2008. Vol. 16. N. 1. P. 37-44.

19. Bjarnsholt T. Why chronic wounds will not heal: a novel hypothesis. Wound Repair Regen. 2008. Vol. 16. N. 1. P. 2-10.

Login or Create
* Forgot password?