Uzbekistan
Tula, Tula, Russian Federation
UDK 616-01/09 Общие вопросы патологии
UDK 61 Медицина. Охрана здоровья
A sufficient number of scientific papers have been accumulated on the association of hyperuricemia with cardiovascular diseases and their consequences (stroke and myocardial infarction), metabolic syndrome, arterial hypertension, insulin resistance, type 2 diabetes mellitus, chronic kidney disease, lipid metabolism disorders, atrial fibrillation. The association of GU with an increased risk of mortality is shown. Pathogenetic connections between the components of the metabolic syndrome have been established.
hyperuricemia, metabolic syndrome, gout, risk factors, hypertension, hyperinsulinemia, vasoconstriction, endothelial dysfunction
1. Eliseev M.S., Barskova V.G., Denisov I.S. Dinamika klinicheskih proyavleniy podagry u muzhchin (dannye 7-letnego retrospektivnogo nablyudeniya). Terapevticheskiy arhiv. - 2015.T. 87. - № 5. - S. 10-5.
2. Ruda M.M., Karpov Yu.A.. Giperurikemiya i serdechno-sosudistyy risk: sovremennyy vzglyad na problemu. AtmosferA. Novosti kardiologii 1*2020str3-15
3. Eliseev M.S., Novikova A.M. Komorbidnost' pri podagre i giperurikemii: rasprostranennost', prichiny, perspektivy uratsnizhayuschey terapii. Terapevticheskiy arhiv. 2019; 91 (5): 120-128. DOI:https://doi.org/10.26442/00403660.2019.05.000232
4. Eliseeva M.E., Eliseev M.S. Znachenie giperurikemii v razvitii zabolevaniy cheloveka i metody ee korrekcii Kardiologiya Terapiya № 2 (157), 2019 str.47-56
5. Eliseev M.S. Hronicheskaya bolezn' pochek: rol' giperurikemii i vozmozhnosti urat-snizhayuschey terapii. Sovremennaya revmatologiya. - 2018. - T. 12. - № 1. - S. 60-5. / Eliseev M.S. Khronicheskaya bolezn' pochek: rol' giperurikemii i vozmozhnosti uratsnizhayushchey terapii. Sovremennaya revmatologiya. 2018; 12 (1): 60-5.
6. Efremova E.V., Shutov A.M., Borodulina E.O.. Problema Komorbidnosti Pri Hronicheskoy Serdechnoy Nedostatochnosti Ul'yanovskiy Mediko-Biologicheskiy Zhurnal. № 4, 2015 Str.47-53.
7. «Obnovlennye v 2018 g. rekomendacii Evropeyskoy protivorevmaticheskoy ligi po diagnostike podagry, osnovannye na fakticheskih dannyh» (2020g.)
8. Il'ina A.E., Barskova V.G., Nasonov E.L. Bessimptomnaya giperurikemiya - pol'za ili vred? RMZh. - 2008. - № 24. - S. 1619. / Il'ina AE, Barskova VG, Nasonov EL. Bessimptomnaya giperurikemiya - pol'za ili vred? RMZH. 2008; 24: 1619. [in Russian].
9. «Klinicheskie rekomendacii Ital'yanskogo obschestva revmatologov» (2019g.),
10. Kobalava Zh.D., Troickaya E.A. Bessimptomnaya giperurikemiya i risk razvitiya serdechno-sosudistyh i pochechnyh zabolevaniy. Kardiologiya. 2020;60(10):113-121
11. Campo C., Ruilope L.M., Segura J. et al. Hyperuricemia, low urine urate excretion and target organ damage in arterial hypertension. Blood press. 2003; 12: 277-283.
12. Bekmatova Sh.K. Struktura Metabolicheskogo Sindroma I Ego Klinicheskoe Znachenie V Razlichnye Periody Zhizni, disser. PhD, Urgench,2021str.5
13. Nedogoda S.V., Salasyuk A.S., Barykina I.N., Ledyaeva A.A., Coma V.V., Chumachek E.V., Hripaeva V.Yu. Vozmozhnosti Korrekcii Giperurikemii Pri Metabolicheskom Sindrome.Medicinskiy sovet №2,2014 str 18-24
14. Denisov IS, Eliseev MS, Barskova VG. Ishody podagry. Obzor literatury. Chast' II. Komorbidnye zabolevaniya, risk razvitiya serdechno-sosudistyh katastrof i smerti pri podagre. Nauchno-prakticheskaya revmatologiya. 2013;51(6):703-10.
15. Mayko O.Yu., Ivanova K.V. Nekotorye Aspekty Racional'noy Terapii Arterial'noy Gipertonii U Bol'nyh Podagroy I Bessimptomnoy Giperurikemiey, Klinicheskaya Gerontologiya, 5-6, 2015 Str60-67,
16. Balanova Yu.A. Arterial'naya gipertoniya v rossiyskoy populyacii: rasprostranennost', vklad v vyzhivaemost' i smertnost', vozmozhnosti snizheniya social'no-ekonomicheskogo uscherba. Disst.dmn.2021,Moskva
17. Malik R., Aneni E.C., Shahrayar S. et al. Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging. Aging Clin. Exp. Res. 2016; 28 (2); 359-62.
18. Kang D., Park S., Lee I., Johnson R. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J. Am. Soc. Nephrol. 2005; 16:3553-3562
19. Markelova E.I. Znachenie sutochnogo monitorirovaniya arterial'nogo davleniya v diagnostike arterial'noy gipertonii u bol'nyh podagroy / E.I. Markelova, V.G. Barskova, A.E. Il'ina i dr. // Nauchno-prakticheskaya revmatologiya. 2010. № 1. S. 61-66.
20. Gustafsson D., Unwin R. The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol. 2013; 14: 164.
21. Ramirez A.J., Christen A.I., Sanchez R.A. Serum Uric Acid Elevation is Associated to Arterial Stiffness in Hypertensive Patients with Metabolic Disturbances. Curr. Hypertens. Rev. 2018; 14(2): 154-60. DOI:https://doi.org/10.2174/1573402114666180413143312
22. Markelova E.I., Eliseev M.S., Barskova V.G. Arterial'naya gipertenziya u bol'nyh podagroy: osnovy patogeneza, klinicheskoe znachenie, diagnostika 2012g Sovremennaya revmatologiya №4,12. Str 23-29
23. Mantovani A, Rigolon R, Civettini A, Bolzan B, Morani G, Bonapace S, Dugo C, Zoppini G, Bonor E, Targher G. Hyperuricemia is associated with an increased prevalence of paroxysmal atrial fibrillation in patients with type 2 diabetes referred for clinically indicated 24h Holter monitoring. Journal of Endocrinological Investigation 2018 Feb;41(2):223-31.
24. Mitsuke Y., Nakaya R., Kiriba C., Tsutani H. Prognositc value of urc acid levels in elderly chronic heart failure patients. J. Cardiac Fail. 2013; 19 (10S): S138, Abstract O-025.
25. Xue Li. Phenome-wide association study (PheWAS) on the genetic determinants of serum urate leveland disease outcomes in UK Biobank. Doctor of Philosophy - The University of Edinburgh - 2018
26. Qin T., Zhou X., Wang J., Wu X., Li Y., Wang L. et al. Hyperuricemia andthe Prognosis of Hypertensive Patients: A Systematic Reviewand MetaAnalysis. J. Clin. Hypertens. (Greenwich). 2016; 18(12): 1268-78. DOIhttps://doi.org/10.1111/jch.12855
27. Soltani Z., Rasheed K., Kapusta D.R., Reisin E. Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal? Curr Hypertens Rep. 2013 Jun; 15 (3): 175-81.
28. Topolyanskaya S.V., Vakulenko O.N., Semashkova A.E., Kupina L.M., Strizhova N.V. Giperurikemiya i serdechno-sosudistye zabolevaniya v starcheskom vozraste. Klin. Med. 2017; 95 (5): 457-464.DOI http://dx.doi.org/10.18821/0023-2149-2017-95-5-457-464
29. Kuwabara M, Niwa K, Nishihara S, Nishi Y, Takahashi O, Kario K, Yamamoto K, Yamashita T, Hisatome I. Hyperuricemia is an independent competing risk factor for atrial fibrillation. International Journal of Cardiology 2017 Mar;231:137-42
30. Richette P., Latourte A., Bardin T. Cardiac and renal protective effects of uratelowering therapy. Rheumatology (Oxford). 2018 Jan1;57 (Suppl 1): i47-i50.
31. Malik R., Aneni E.C., Shahrayar S. et al. Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging. Aging Clin. Exp. Res. 2016; 28 (2); 359-62.
32. Orlova E.V.Giperurikemiya v terapevticheskoy praktike - lechit' ili nablyudat'/ Trudnyy pacient №10, TOM 16, 2018 str.17 DOI:https://doi.org/10.24411/2074-1995-2018-10015)
33. Ferreira T.D.S., Fernandes J.F.R., Araújo L.D.S., Nogueira L.P., Leal P.M., Antunes V.P. et al. Serum Uric Acid Levels are Associated with Cardiometabolic Risk Factors in Healthy Young and Middle-Aged Adults. Arq. Bras. Cardiol. 2018; 111(6): 833-40. DOI: 10.5935/ abc.20180197.
34. Toirov H.K., Kardiovaskulyarnye narusheniya pri podagre. Disst. kmn.2013, Dushanbe
35. Umarova Sh.Z., Sultanbaeva N.M.U. Optimizaciya sistemnoy farmacevticheskoy pomoschi dlya bol'nyh serdechno-sosudistymi zabolevaniyami. Tashkent 2020
36. Larina V. N., Bart B. Ya., Larin V. G., Donskov A. S. Giperurikemiya I Serdechno-Sosudistyy Kontinuum. Klinicheskaya Medicina, № 1, 2013. Str11-16
37. Cicero A.F., Rosticci M., Fogacci F., Grandi E., D'Addato S., Borghi C.;Brisighella Heart Study Group. High serum uric acid is associated to poorly controlled blood pressure and higher arterial stiffness in hypertensive subjects. Eur. J. Intern. Med. 2017; 37: 38-42. DOIhttps://doi.org/10.1016/j.ejim.2016.07.026.
38. Topolyanskaya S.V., Vakulenko O.N., Semashkova A.E., Kupina L.M., Strizhova N.V. Giperurikemiya i serdechno-sosudistye zabolevaniya v starcheskom vozraste. Klin. Med. 2017; 95 (5): 457-464.DOI http://dx.doi.org/10.18821/0023-2149-2017-95-5-457-464
39. Rossiyskoe medicinskoe obschestvo po arterial'noy gipertonii. Rekomendacii po vedeniyu bol'nyh arterial'noy gipertoniey s metabolicheskimi narusheniyami i saharnym diabetom 2-go tipa. Sistemnye gipertenzii. 2020; 17 (1): 7-45. DOI:https://doi.org/10.26442/2075082X.2020.1.200051
40. Kushnarenko N.N Serdechno-sosudistye narusheniya u muzhchin s podagroy: klinicheskie osobennosti, mehanizmy razvitiya, prognozirovanie, dissert., 2012
41. Kobalava Zh.D., Troickaya E.A. Bessimptomnaya giperurikemiya i risk razvitiya serdechno-sosudistyh i pochechnyh zabolevaniy. Kardiologiya. 2020;60(10):113-121
42. Lin K.C., Lin H.Y., Chou P. The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. J. Rheumatol. 2000; 27(6): 1501-5.;
43. Park J.J., Roudier M.P., Soman D., Mokadam N.A., Simkin P.A. Prevalence of birefringent crystals in cardiac and prostatic tissues, an observational study. BMJ Open. 2014; 4(7): e005308. DOI: 10.1136/
44. Zhernakova Yu.V., Chazova I.E., Oschepkova E.V. i dr. Rasprostranennost' saharnogo diabeta v populyacii bol'nyh arterial'noy gipertoniey. Po dannym issledovaniya ESSE-RF. Sistemnye gipertenzii. 2018; 15 (1): 56-62. [Zhernakova Iu.V., Chazova I.E., Oshchepkova E.V. et al. Rasprostranennost' sakharnogo diabeta v populiatsii bol'nykh arterial'noi gipertoniei. Po dannym issledovaniia ESSE-RF. Systemic Hypertension. 2018; 15 (1): 56-62 (in Russian).
45. Demidova T.Yu., Kishkovich Yu.S. Prediabet: sovremennoe sostoyanie problemy i vozmozhnosti korrekcii. RMZh(Russkiy medicinskiy zhurnal). Medicinskoe obozrenie. 2019;3(10(II)):60-67.
46. International Diabetes Federation. IDF Diabetes Atlas. 9th edition. IDF; 2019; c.168.
47. Feig D.I., Kang D.H., Johnson R.J. Uric acid and cardiovascular risk.N. Engl. J. Med. 2008; 359: 1811-21.
48. Feig D.I., Nakagawa T., Karumanchi S.A. et al. Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int 2004;66:281-7.
49. Anker S.D., Doehner W., Rauchhaus M. et al. Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging. Circulation 2003; 107: 1991-7.
