Russian Federation
Russian Federation
Netherlands
Irkutsk Scientific Center SB RAS (otdel mediko-biologicheskih issledovaniy i tehnologiy, zaveduyuschiy)
Irkutsk, Irkutsk region, Russian Federation
Aim: to reveal the association of gene CYP2C19 polymorphisms and efficacy and safety endpoints of clopidogrel therapy in patients with acute coronary syndrome. Materials and methods. A total of 431 patients with acute coronary syndrome undergoing coronary stent placement was studied. CYP2C19 polymorphisms (*2, *3, *17) were evaluated, platelet aggregation with ADP and efficacy and safety for 30 days after coronary stent placement was studied. Results. Within the selected patients there was no significant association between carriage of at least one allele of the CYP2C19*2, and/or CYP2C19*3 and paradoxical response to clopidogrel. Significant association between carriage of allele CYP2C19*17 and the presence of bleeding was detected. The algorithm for selection of individual drug therapy for patients receiving clopidogrel therapy was developed. Conclusion. The results can be extremely important for decision-making about the strategy of dual antiplatelet therapy and the tactics of choice of drugs.
CYP2C19, clopidogrel, paradoxical reaction, stent thrombosis, residual platelet aggregation, dual antiplat elet t herapy
Одним из основных препаратов для двойной антитромбоцитарной терапии в кардиологии является клопидогрел, использование которого позволяет снизить частоту тромботических осложнений. Антитромбоцитарная терапия для
оптимизации результатов стентирования коронарных сосудов должна обеспечивать баланс между минимизированным риском тромбоза стентов и риском кровотечения [1].
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