Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy

V. Solodkiy; V. M. Sotnikov; S. Trotsenko; V. Kharchenko; V. Chkhikvadze; N. Nudnov; G. Panshin; A. Morgunov

doi:10.12737/article_5c0b90d10ff212.78053112

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NON-SMALL CELL LUNG CANCER RECURRENCES AFTER SURGICAL AND COMBINED MODALITY TREATMENT WITH POSTOPERATIVE RADIATION THERAPY Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy

АА Аа

Published in Medical Radiology and radiation safety · Volume 63, Issue 6 · Pages 59–64 · Rubric: Radiation therapy

DOI: https://doi.org/10.12737/article_5c0b90d10ff212.78053112

Received: 21.11.2018 Accepted: 24.03.2024 Language of publication: RUS

Authors

V. Solodkiy

V. M. Sotnikov

S. Trotsenko

V. Kharchenko

et al.

V. Chkhikvadze

N. Nudnov

G. Panshin

A. Morgunov

V. Solodkiy

Academic degree: doctor of medical sciences

Science rang: academician author.academy_titles.32

Russian Scientific Center of Roentgenoradiology Director · Russian Federation · Moscow

V. M. Sotnikov

Academic degree: doctor of medical sciences

Science rang: professor

Russian Scientific Center of Roentgenoradiology Head of Laboratory · Russian Federation · Moscow

S. Trotsenko

Academic degree: candidate of medical sciences

Russian Scientific Center of Roentgenoradiology Radiologist · Russian Federation · Moscow

V. Kharchenko

Academic degree: doctor of medical sciences

Science rang: academician author.academy_titles.32

Russian Scientific Center of Roentgenoradiology Scientific Supervisor · Russian Federation · Moscow

V. Chkhikvadze

Academic degree: doctor of medical sciences

Russian Scientific Center of Roentgenoradiology Head of Department · Russian Federation · Moscow

N. Nudnov

Academic degree: doctor of medical sciences

Russian Scientific Center of Roentgenoradiology Deputy Director · Russian Federation · Moscow

G. Panshin

Academic degree: doctor of medical sciences

Russian Scientific Center of Roentgenoradiology Head of Department · Russian Federation · Moscow

A. Morgunov

Russian Scientific Center of Roentgenoradiology Senior Researcher · Russian Federation · Moscow

ABSTRACT

Purpose: To compare the patterns of the relapses after the surgical and combined modality treatment of non-small cell lung cancer (NSCLC) with the postoperative radiotherapy (PORT). Material and methods: The comparative evaluation of the patterns of the relapses was carried out in 528 NSCLC patients with the IA–IIIB stage after surgical treatment (n = 174) and combined modality treatment (n = 354) using PORT in the hypofractionation regimen 3 Gy/fraction, 5 times a week, TD 36–39 Gy (EQD2 = 43.2–46.8 Gy, α/β = 3) and classical fractionation 2 Gy/fraction, 5 times a week, TD 44 Gy. Results: The local and the regional relapses developed from 2 to 59 months after treatment, most often in the first three years of follow-up (median 15 months). The local and the regional relapses were statistically significantly more frequent in the surgical treatment group (31.6 % vs 7.1 %). The frequency of the distant metastases in the both groups was not statistically different (46.6 % vs 42.3 %), however, in the surgical treatment group, the distant metastases were more often combined with the locoregional relapses (18.4 % vs 4.5 %). Surgery+PORT in comparison with surgical treatment alone reduces the incidence of locoregional recurrence at the central location of the tumor (8.8 % vs 40.0 %), peripheral non-small cell lung cancer (5.2 % vs 26.0 %), with squamous histological type of tumor (8.4 % vs 37.5 %) and in adenocarcinoma (4.6 % vs 26.4 %), regardless of the volume of surgical treatment (pneumonectomy – 7.0 % vs 47, 1 %, p = 0.0002, lobectomy and bilobectomy – 7.1 % vs 20.6 %, p = 0.001, segmentectomy – 7.1 % vs 50.0 %, p = 0.0001). In the subgroup of patients undergoing adjuvant chemotherapy and PORT, the local, regional and locoregional relapses were statistically significantly less common than in the group of non-small cell lung cancer patients who received only adjuvant chemotherapy (3.9 % vs 17.5 %, p = 0.002, 5.4 % vs 23.8 %, p = 0.001, 6.2 % vs 36.5 %, p = 0.0001). The number of combined relapses (local and/or regional relapses + distant metastases) was actually four times less in all subgroups of patients with PORT (4.7 % vs 20.6 %, p = 0.001). Conclusion: PORT as the part of combined treatment of non-small cell lung cancer statistically significantly reduces the incidence of the local, regional, locoregional and combined relapses in the squamous cell lung cancer and adenocarcinoma, central and peripheral localization of the tumor, after surgical treatment in the volume of pneumonectomy, lob-bilobectomy and segmentectomy, and when using with or without adjuvant chemotherapy.

KEYWORDS

lung cancer, surgical treatment, combined modality treatment, postoperative radiation therapy, the characteristic of recurrences

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GOST

Solodkiy V. A., Sotnikov V. M., Trotsenko S. D., Kharchenko V. P., Chkhikvadze V. D., Nudnov N. V., Panshin G. A., Morgunov A. A. Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy // Medical Radiology and radiation safety. 2018. no. 6. pp. 59-64. DOI: https://doi.org/10.12737/article_5c0b90d10ff212.78053112. (Date of access 09.10.2026).

MLA

V. Solodkiy, Sotnikov V. M., Trotsenko S. D., Kharchenko V. P., Chkhikvadze V. D., Nudnov N. V., Panshin G. A., Morgunov A. A.. "Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy." Medical Radiology and radiation safety 63.6 (2018): 59-64. DOI: https://doi.org/10.12737/article_5c0b90d10ff212.78053112.

APA

Solodkiy V. A., Sotnikov V. M., Trotsenko S. D., Kharchenko V. P., Chkhikvadze V. D., Nudnov N. V., Panshin G. A., Morgunov A. A. (2018). Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy. Medical Radiology and radiation safety, 63(6), 59-64. https://doi.org/10.12737/article_5c0b90d10ff212.78053112

Chicago

V. Solodkiy, Sotnikov V. M., Trotsenko S. D., Kharchenko V. P., Chkhikvadze V. D., Nudnov N. V., Panshin G. A., Morgunov A. A.. "Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy." Medical Radiology and radiation safety 63, no. 6 (2018): 59-64. https://doi.org/10.12737/article_5c0b90d10ff212.78053112.

WIKI

{{cite journal | author = Solodkiy V. A., Sotnikov V. M., Trotsenko S. D., Kharchenko V. P., Chkhikvadze V. D., Nudnov N. V., Panshin G. A., Morgunov A. A. | title = Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy | journal = Medical Radiology and radiation safety | year = 2018 | volume = 63 | issue = 6 | pages = 59-64 | doi = 10.12737/article_5c0b90d10ff212.78053112 }}

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NON-SMALL CELL LUNG CANCER RECURRENCES AFTER SURGICAL AND COMBINED MODALITY TREATMENT WITH POSTOPERATIVE RADIATION THERAPY Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy

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