THE INFLUENCE OF THE HORMONE-THERAPY ON THE SEX HORMONE LEVELS OF THE WOMEN WITH THE FIBROADENOMAS OF THE MAMMARY GLANDS, OPERATED BY VACUUM EXTRACTION
Authors:
Type:
Article
Pages:
from 47
to 53
Status:
Published
Received:
28.12.2015
Accepted:
28.12.2015
Published:
28.12.2015
Language:
Russian
Keywords:
benign breast disease, vacuum aspiration of the tumor, sex hormones, hormone‐therapy.
Abstract (English):
48 women at the age of 26,5±3,8 with the benign tumors of the mammary glands (fibroadenomas) were operated by means of vacuum aspiration with the En‐cor apparatus (made in the USA) under the ultrasound control. The tactics of the surgery satisfied the requirements (standards) accepted in Russia. In the core group (II, 20 patients) low‐dose monophasic combination oral contraceptives with the ethinylastradicol as an active ingredient at a dose of 20 mcg were prescribed for six months beginning with the 1st day of the menstrual cycle (period) which followed the operation. In the group of comparison (22 patients) the hormone‐therapy during the post‐operative period wasn’t carried out. The observing time after the operation lasted in average two and a half years (the maximal duration was 3,2 years, the minimal one – 2,1 years). For the two check points the date of the access and the sixth month after the adenomammectomy were chosen. During this time the laboratory, breast ultrasound and the clinical forms of control of the condition of the mammary gland and of the hormonal background were carried out. The investigation revealed the normalization of the background of the female and the male sex hormones after the adenomammectomy by means of the aspiration method. It was characteristic for the women to whom the hormone‐therapy after the adenomammectomy was prescribed that the changes with them were maximal. Apart from the normalization of the general hormonal background of these women there were also some signs of a significant reduction in the risk of recurrence and the development of new fibroadenoma of breast.
48 women at the age of 26,5±3,8 with the benign tumors of the mammary glands (fibroadenomas) were operated by means of vacuum aspiration with the En‐cor apparatus (made in the USA) under the ultrasound control. The tactics of the surgery satisfied the requirements (standards) accepted in Russia. In the core group (II, 20 patients) low‐dose monophasic combination oral contraceptives with the ethinylastradicol as an active ingredient at a dose of 20 mcg were prescribed for six months beginning with the 1st day of the menstrual cycle (period) which followed the operation. In the group of comparison (22 patients) the hormone‐therapy during the post‐operative period wasn’t carried out. The observing time after the operation lasted in average two and a half years (the maximal duration was 3,2 years, the minimal one – 2,1 years). For the two check points the date of the access and the sixth month after the adenomammectomy were chosen. During this time the laboratory, breast ultrasound and the clinical forms of control of the condition of the mammary gland and of the hormonal background were carried out. The investigation revealed the normalization of the background of the female and the male sex hormones after the adenomammectomy by means of the aspiration method. It was characteristic for the women to whom the hormone‐therapy after the adenomammectomy was prescribed that the changes with them were maximal. Apart from the normalization of the general hormonal background of these women there were also some signs of a significant reduction in the risk of recurrence and the development of new fibroadenoma of breast.
Keywords:
benign breast disease, vacuum aspiration of the tumor, sex hormones, hormone‐therapy.
benign breast disease, vacuum aspiration of the tumor, sex hormones, hormone‐therapy.
Доброкачественные новообразо‐
вания молочных желез не являются облигат‐
ными предраковыми состояниями, однако на
их фоне частота возникновения рака молочной
железы в 4‐5 раз выше, чем в популяции, а при
локализованных формах фиброзно‐кистозной
болезни с явлениями пролиферации – выше в
35‐40 раз [4,8,11]. На сегодня основной онколо‐
гической патологией у женщин репродуктив‐
ного возраста являются доброкачественные но‐
вообразования молочных желез, наиболее час‐
тые из которых служат фиброаденомы [3,6].
