The purpose of the study was to identify the relationship between the initial state of the organism and the result of the treatment of hypertrophic scars. 38women of 16–35years of age were examined on the 5–7th days of the menstrual cycle, 16 of them had normotrophic scars and 22 – hypertrophic scars. The quality of scars, lipid profile, the concen-tration of thyrotropin, free fraction of thyroxine, growth hormone (GH), luteinizing and follicle stimulating hormone (FSH), cortisol, prolactin, estradiol, testosterone, progesterone , the concentration of TNF-α, IL-4, IL-6, IL-10, and the level of autoantibodies to DNA, IFN-α , IFN-γ, b2-glycoprotein, Fc-fragments, collagen-2 were determined. Further on the laser treatment was performed: the scar surface was treated by multiple perforations under local anesthesia. Treatment outcome was assessed in 3months by the clinical characteristics of the scar. It was found that in 10women hypertrophic scars reformed in normotrophic scars after the treatment, and 12women still had hypertrophic scars. Patients with a positive result of treatment had a low concentration of GH (0.5±0.1) and high concentrations of proges-terone (6.0±0.4) and FSH (6.7±0.5 in the follicular phase of the cycle). The negative result of the treatment obtained in patients with significant shifts reactivity indicators: high atherogenic index (2.6±0.2) and the level of GH (2.1±0.5), low levels of cortisol (346.8±39), testosterone (1.5±0.2), IL-10 (3.89±1.6) and antibodies to IFN-γ (0.206±0.05), IFN-α (0.385±0.02), Fc-fragments (0.317±0.04).
treatment of hypertrophic scars, reactivity, pathogenesis of hypertrophic scars
1. PolyakovLM, SumenkovaDV, KnyazevRA (2011).Analysis of the interaction of lipoproteins and steroid hormones [Analiz vzaimodeystviya lipoproteinov i steroidnykh gormonov]. Biomeditsinskaya khimiya, 57(3), 308-313.
2. TenchurinaTG (2005). Significance of sex steroids and angiogenic growth factors in the prevention of scarring complications after cosmetic surgery [Znachenie polovykh steroidov i angiogennykh faktorov rosta v profilaktike os-lozhneniy rubtsevaniya posle kosmeticheskikh operatsiy]. Eksperimental’naya i klinicheskaya dermatokosmetologiya, (4), 17-20
3. SchwartzYS (2009). Effects of cholesterol and nuclear hormone receptor agonists in the production of trans-forming growth factor-beta in macrophages [Deystvie kholesterina i agonistov yadernykh gormonal’nykh ret-septorov na produktsiyu transformiruyushchego faktora rosta-beta v makrofagakh]. Byulleten’ eksperimental’noy biologii i meditsiny, (9), 294-297.
4. AshcroftGS, DodsworthJ, van BoxtelE (1997). Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med., 3(11), 1209-1215.
5. GilliverSC (2006). Androgens modulate the inflammatory response during acute wound healing. J.CellSci., 119(4), 722-732
6. FruchtmanS, SimmonsJG, MichayliraCZ (2005). Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells. Am.J..Physiol. Gastrointest. Liver Physiol., 289(2), 342-350
7. HuZC, TangB, GuoD, ZhangJ, LiangYY, MaD,ZhuJY (2014). Expression of insulin-like growth factor-1 receptor in keloid and hypertrophic scar. Clin. Exp. Dermatol.,39(7), 822-828.
8. KandaN, WatanabeS (2005) Regulatory roles of sex hormones in cutaneous biology and immunology. J.Dermatol. Sci., 38(1), 1-7
9. KaramoutiM, KolliaP, KallitsarisA, Vamvakopou-losN, KolliosG, MessinisIE (2008) Growth hormone, insulin-like growth factor I, and leptin interaction in hu-man cultured lutein granulosa cells steroidogenesis. Fertil. Steril., 90(4), 1444-1450
10. LawrenceJW (2012). Epidemiology and impact of scarring after burn injury: a systematic review of the literature. J.Burn. Care Res., 33(1), 136-146.
11. SchmidtM, RennerC, LöfflerG (1998) Proges-terone inhibits glucocorticoid-dependent aromatase induction in human adipose fibroblasts. J.Endocrinol.,158(3), 401-407.
12. TaketaniT, YamagataY, TakasakiA, MatsuokaA, TamuraH, SuginoN (2008) Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells. Fertil. Steril., 90(3), 744-748.
13. Van VugtHH (2008). Somatostatin in the rat periventricular nucleus: sex differences and effect of gonadal steroids. Exp.Brain.Res., 188(4), 483-491.
14. WangJ, JiaoH, StewartTL, ShankowskyHA,ScottPG, TredgetEE (2007). Increased TGF-beta-producing CD4+ T lymphocytes in postburn patients and their potential interaction with dermal fibroblasts in hypertrophic scarring. Wound Repair Regen., 15(4), 530-539.
15. ZhuZ, DingJ, ShankowskyHA, TredgetEE (2013).The molecular mechanism of hypertrophic scar. J.Cell. Commun. Signal., 7(4), 239-252.
