Clinical data are based on material obtained during the examination and treatment of 88 patients with different forms of acute intestinal obstruction non-tumor genesis. The subjects were: men – 48 (54.5%), 40 women (45.5%). Low small bowel obstruction was the most common in 61.7% of patients, high level – in 38.3%. Among 88 patients, 29.4% of patients were in the stage of ischemia - reperfusion IPOs, 29.4% of patients with volemic disorders and 41.2% – in the stage of peritonitis. 42 patients of the main group received complex postoperative therapy, and endolymphatic administration of Cytoflavin and Sulodexide. The patients of comparison group had standard treatment. The clinical results indicate that the use of endolymphatic drug therapy in complex therapy of acute intestinal obstruction allows to optimizing the course of early postoperative period. Postoperative complications decreased in 9.7%; the mortality in 5.7%; and rate of bed – days at 3. Comparative characteristics proved that endolymphatic drug therapy provides adequate correction of immunological disorders, reducing the intensity of lipid peroxidation. The reduction of hypoxia was recorded in the main group. The content of lactic and pyruvic acids in plasma, respectively, is decreased by 9.8 and 14.8%. The results show that the use of Cytoflavin and Sulodexide results in strengthening the integral response of the immune system.
endolymphatic drug therapy, acute intestinal obstruction, ischemia – reperfusion
1. Vlasov A.P., Trofimov V.A., Krylov V.G. Sistemnyy lipidnyy distress-sindrom v khirurgii. M.: Nauka, 2009. S. 224.
2. Grinev M.V., Kurygin A.A., Khanevich M.D. Ostraya kishechnaya neprokhodimost´ kak problema neotlozhnoy khirurgii. Vest.khir. 1992. №5. S.130-138.
3. Dobritsa V.P., Boterashvili N.M., Dobritsa E.V. Sovremennye immunomodulyatory dlya klinicheskogo primeneniya. Rukovodstvo dlya vrachey. SPb.: Politekhnika, 2001. S. 164-165.
4. Zatevakhin I.I., Magomedova E.G., Pashkov D.I. Rak tolstoy kishki, oslozhnennyy obturatsionnoy kishechnoy neprokhodimost´yu. Vestnik khirurgicheskoy gastroenterologii. 2010. № 2. S. 30-34.
5. Osobennosti formirovaniya entero-enteroanastomoza v usloviyakh peritonita / Zubritskiy V.F., Osipov I.S., Shadrivova E.V. [i dr.]. Khirurgiya. 2009. № 12. S. 25-29.
6. Sindrom kishechnoy nedostatochnosti v abdominal´noy khirurgii / Ermolov A.S., Popova T.S., Pakhomova G.V. [i dr.]. M.: MedEkspertPress, 2005. S. 450.
7. Izmaylov S.G., Izmaylov G.A., Podushkina I.V. Lechenie ran. Kazan´: Izd-vo KGTU, 2003. 292 s.
8. Karsonova M.I., Pinegin B.V., Khaitov R.M. Immunokorregiruyushchaya terapiya pri khirurgicheskoy infektsii. Analizy khirurgicheskoy gepatologii. 1999. Tom 4, №1. S. 88-96.
9. Magomedov M.M., Aligadzhiev D.M. Ostraya kishechnaya neprokhodimost´. Makhachkala, 2007. 260 s.
10. Sil´manovich N.N., Yarema V.I., Tkachev V.K., Yarema V.M. Khirurgicheskie metody immunokorrektsii. Khirurg. 2007. №7. S. 28-37.
11. Struchkov Yu.V., Sotnikov D.N., Kurilov V.P. Korrektsiya enteral´noy nedostatochnosti pri ostroy kishechnoy neprokhodimosti. Meditsinskie nauki. 2010. № 5. S. 29-34.
12. Bailey I.S. Laparoscopic management of acute small bowel obstruction. Br. J. Surg. 2008. № 1. P. 84-87.
13. Rauchfuss E. The immunomodulator GAJLAVIT - a new’ hope for cancer patients?. Achievements in science & technology of research in the black sea region. 2001. P. 46-48.
14. Sehlag G., Redl H. Mediators of injury and inflammation. World. J. Surgery. 1996. V. 20, №4. P. 406-410.
15. Wilson P.G., Manji M., Neoptolemos J.P. Acute pancreatitis as a model of sepsis. J. Antimicrob. Chemother. 1998. V. 41. P. 51-63.
16. Wittman R.H. Intraabdominal infections. Introduction. World. J Surgery. 1990. V. 14, №2. P. 145-147.
17. Wilson M.S. Natural history of adhesional small bowel obstruction: counting the cost. Br. J. Surg. 2008. №9. P. 85-94.
