Благовещенск, Амурская область, Россия
Благовещенск, Амурская область, Россия
Прогестерон – естественный стероидный гормон, выполняющий в организме множество функций, регулирующих работу репродуктивных и нерепродуктивных тканей. В статье рассмотрен механизм эффектов гормона. Представлены данные о геномном и негеномном способах действия прогестерона, осуществляющегося через разные виды рецепторов: внутриклеточных и плазмомембранных. Специфические эффекты прогестерона в различных тканях зависят от набора рецепторов и их корегуляторов. Прогестерон является главным гормоном беременности, поэтому большой раздел обзора посвящен его действию в этот период. К функциям гормона относятся: участие в процессах овуляции и имплантации, преобразование эндометрия в децидуальную ткань, торможение сократимости матки, подавление иммунной системы матери, накопление питательных веществ в виде подкожного жира для обеспечения ими плода, рост и развитие молочных желез, участие в развитии тканей зародыша. Детально рассмотрены несколько эффектов предотвращения сократимости миометрия и механизм перехода иммунной системы матери на функционирование в условиях беременности. Помимо роли гормона во время беременности кратко описана регуляция других важных функций организма человека.
прогестерон, механизм действия, беременность
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