Moskva, Moscow, Russian Federation
Modern bioengineering research requires the development artificial nutrient supply systems (ANSS) for organs-on-a-chip capable of efficiently delivering nutrients and oxygen to cellular structures. One of the key problems is the modeling of vascular networks that ensure the viability of tissues in vitro. In this paper, a solution based on fractal geometric models simulating the circulatory system of living organisms is proposed. The research focuses on two-dimensional fractal trees, the parameters of which (branching angles, depth of the permeability zone, similarity coefficients) are optimized to maximize power efficiency (F). Parametric models have been developed in the COMPASS 3D CAD system and a specialized program "Fractal IPS v1.18", which allows automating calculations. It is shown that the best results are achieved at branching angles from 90° to 180°, as well as with variable selection of parameters R and j, which allows increasing F up to 70%. The results of the work can be applied not only in bioengineering, but also in microelectronics (cooling systems) and agrotechnics (irrigation systems). A promising area of further research is the transition to three-dimensional models and multiparametric optimization algorithms.
organs-on-a-chip, fractal models, geometric modeling, artificial feeding system, geometric optimization
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