Аннотация (русский):
В обзоре представлены результаты экспериментальных исследований о влиянии гипертермии на физиологические процессы в злокачественных опухолях и нормальных тканях: кровоток, уровни PО2, рН, синтез белков теплового шока. Также изучен противоопухолевый иммунитет и метастазирование опухоли при действии гипертермии. Дан анализ радио- и химосенсибилизирующего действия гипертермии, ее роли при термолипосомальной химиотерапии и возможности применения метода с магнитными наночастицами в онкологии.

Ключевые слова:
гипертермия, злокачественные опухоли, нормальные ткани, PО2, рН, белки теплового шока, термотолерантность, противоопухолевый иммунитет, раковые стволовые клетки, метастазирование, термолипосомы, магнитные наночастицы

В онкологии под гипертермией (ГТ) подразумевается нагревание опухоли при 39–46 °C с целью модификации действия лучевой, лекарственной, иммуно- и гормонотерапии. Температурный режим 39–40 °C используется при общей гипертермии, 41–46 °C – локорегионарной. В первом случае продолжительность ГТ в режиме плато составляет 180 мин и более, во 2-ом – 30–90 мин [1–6].

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