The paradigm of formation of science about nitrogen-containing compounds (protein complex) of raw milk - Proteomics - is stated. The monitoring of fractional composition, possibility of extraction, modification and application of the whole protein complex, caseins and serum proteins, their fractions and derivatives allows to consider the traditional and innovative component of dairy business in an absolutely new light, based on nanoclusters and biotechnology. The road map of casein complex of raw milk is considered. The characteristic of the main fractions of casein, from the point of view of modern biotechnology of cheeses and cottage cheese is provided. The characteristic of serum proteins of raw milk in the native and denatured states and after the microparticulation directed into nanotubes is separately considered. The unimproved opportunities for the modernization of technologies of extraction of protein clusters with the receipt of products for import substitution with export orientation are emphasized. For the first time in the logistics of system analysis the problems of controlled proteolysis of albumins of milk - casein and serum proteins, with the receipt of products for clinical nutrition are considered.
milk proteins, casein, whey proteins, amino acids, composition and properties of protein complex of milk, ways of receipt, ways of use
1. Khramtsov A.G. Laltoomika as the science of milk. Modernization of our ideas. Dairy Industry, 2011, no. 6, pp. 45-48. (In Russian).
2. Khramtsov A.G. Innovatsionnye prioritety i praktika tekhnologicheskoy platformy modernizatsii molochnoy otrasli APK [innovative priorities and practice of technological platform of modernization of dairy industry of agrarian and industrial complex]. Voronezh: VSUET Publ., 2015. 260 p.
3. Khramtsov A.G. and Anisimov S.V. Logistika innovatsionnykh prioritetov tekhnologicheskoy platformy molochnogo dela v usloviyakh ogranichennykh resursov traditsionnogo syr'ya, realiy rynochnoy ekonomiki i VTO (na primere molochnogo kombinata «Stavropol'skiy») [logistics of innovative priorities of technological platform of dairy business under the conditions of limited resources of traditional raw materials, realities of market economy and the wto (using the example of the dairy combine "stavropolsky")]. Materialy Mezhdunarodnoy nauchno-prakticheskoy konferentsii «Innovatsionnye tekhnologii v proizvodstve i pererabotke sel'skokhozyaystvennoy produktsii v usloviyakh VTO» [Proc. of the Inter. Sci. and Prac. Conf. “Innovative Technologies in Production and Processing of Agricultural Products under the Conditions of the WTO”]. Volgograd, 2013, June 4-5, pp. 191.
4. Khramtsov A.G. Glycoomics clusters of lactose and its derivatives in nanotechnology of living cultures. Food and Raw Materials, 2015, vol. 3, no. 1, pp. 3-12. DOI:https://doi.org/10.12737/11168.
5. Khramtsov A.G. An epistemological background on paradigm formation of lipidomics of dairy industry. Food and Raw Materials, 2016, vol. 4, no. 1, pp. 79-89. DOI:https://doi.org/10.21179/2308-4057-2016-1-79-89.
6. Tepel A. Khimiya i fizika moloka [Chemistry and physics of milk]. St. Petersburg: Professija Publ., 2012. 832 p.
7. El'chaninov V.V., Koval' A.D., and Belov A.N. Some technological aspects of receiving cow milk whey proteins. 1. Introduction. Principle strategies of the group division of whey proteins and caseins. Dairy Industry, 2015, no. 2, pp. 40-41. (In Russian).
8. El'chaninov V.V. Some technological aspects of receiving whey proteins of cow milk. 2. Production of milk whey and products fortified with whey proteins. Dairy Industry, 2015, no. 3, pp. 64-66. (In Russian).
9. El'chaninov V.V., Koval' A.D., and Belov A.N. Some technological aspects of receiving cow milk whey proteins. 3. Receiving of ß-lactoglobulin and a-lactalbumin in the denatured or partially denatured forms. Dairy Industry, 2015, no. 4, pp. 50-52. (In Russian).
10. El'chaninov V.V. Issledovanie molokosvertyvayushchego fermenta iz sychugov severnykh oleney. Diss. kand. tekhn. nauk [Research of Milk-Clotting Enzyme from the Rennets of Reindeers. Dr. eng. sci. diss] Kemerovo, 2005. 172 p.
11. Trukhachev V.I., Molochnikov V.V., Orlova T.А., et al. Teoriya i praktika bezotkhodnoy pererabotki moloka v zamknutom tekhnologicheskom tsikle [Theory and Practice of Waste-Free Milk Processing in a Closed Technological Cycle]. Stavropol: AGRUS Publ., 2012. 360 p.
12. Gorbatova K.K. Khimiya i fizika belkov moloka [Chemistry and physics of milk proteins]. Moscow: Kolos Publ., 1993. 192 p.
13. Merkulova N.G., Merkulov M.Yu., and Merkulov I.Yu. Proizvodstvennyy kontrol' v molochnoy promyshlennosti [Production Control in the Dairy Industry]. St. Petersburg: Professija Publ., 2009. 334 p.
14. Yurova E.A., Kobzeva T.V., Parfenova E.Yu., and Mel'denberg D.N. Specifics of Control of Milk Protein. Milk Processing, 2014, no. 12, pp. 6-9. (In Russian).
15. Dolgonosov A.M., Rudakov O.B., Surovtsev I.S., and Prudkovskiy A.G. Kolonochnaya analiticheskaya khromatografiya kak ob''ekt matematicheskogo modelirovaniya [Columnar Analytical Chromatography as the Subject of Mathematical Modeling]. Voronezh: Voronezh State Technical University Publ., 2013. 400 p.
16. D'yachenko P.F. Issledovanie belkov moloka v svyazi s ego promyshlennoy pererabotkoy. Avtoref. diss. dokt. tekhn. nauk [Research of Milk Proteins in Connection with its Industrial Processing. Dr. eng. sci. thesis]. Мoscow, 1957. 40 p.
17. Gorbatova K.K. Biokhimiya moloka i molochnykh produktov [Biochemistry of Milk and Milk Products]. Moscow: GIORD Publ., 2003. 320 p.
18. Osintsev A.M. Razvitie fundamental'nogo podkhoda k tekhnologii molochnykh produktov [Development of Fundamental Approach to the Technology of Dairy Products]. Kemerovo: KemIFST Publ., 2004. 152 p.
19. Smykov I.T. Modelirovanie protsessov strukturirovaniya i upravlenie strukturoobrazovaniem v geterogennykh biopolimernykh sistemakh. Diss. dokt. tekhn. nauk [Modeling of Processes of Structuring and Control of Structurization in Heterogeneous Biopolymer Systems. Dr. eng. sci. diss.]. Uglich, 2014. 370 p.
20. Babich O.O. Issledovanie i razrabotka tekhnologii molochnogo belkovogo ekvivalenta dlya spetsializirovannykh produktov pitaniya. Diss. kand. tekhn. nauk [Research and Development of Technology of Milk Protein Equivalent for Specialized Foodstuffs. Dr. eng. sci. diss.]. Kemerovo, 2009. 115 p.
21. Witten T.A. and Sander L.M. Diffusion-Limited Aggregation, a Kinetic Critical Phenomenon. Physical Review Letters, 1981, vol. 47, no. 19, pp. 1400-1403. DOI:https://doi.org/10.1103/PhysRevLett.47.1400.
22. Vold M.J. Computer Simulation of Floc Formation in a Colloidal Suspension. Journal of Colloid Science, 1963, vol. 18, no. 7, pp. 684-695. DOI:https://doi.org/10.1016/0095-8522(63)90061-8.
23. Vold R.D. and Vold M.J. Colloid and Interface Chemistry. Reading: Addison-Wesley, 1983. 694 p.
24. Meakin P.A. Effects of cluster trajectories on cluster- cluster aggregation: A comparison of linear and Brownian trajectories in two-and three-dimensional simulation. Physical Review A, 1984, vol. 29, no. 2, pp. 997-999. DOI: https://doi.org/10.1103/PhysRevA.29.997.
25. Eden M. Proceedings of the Fourth Berkeley Symposium on Mathematical Statistics and Probability. Berkeley: Univ. of California Publ., 1961, vol. 4. 223 p.
26. Ball R.C., Weitz D.A., Witten T.A., and Leyvraz F. Universal Kinetics in Reaction-Limited Aggregation. Physical Review Letters, 1987, vol. 58, no. 3, pp. 274-277. DOI: https://doi.org/10.1103/PhysRevLett.58.274.
27. Schaefer D.W., Martin J.E., Wiltzius P., and Cannell D.S. Fractal Geometry of Colloidal Aggregation. Physical Review Letters, 1984, vol. 52, no. 26, pp. 2371. DOI: https://doi.org/10.1103/PhysRevLett.52.2371.
28. Meakin P.A. Historical Introduction to Computer Models for Fractal Aggregates. Journal of Sol-Gel Science and Technology, 1999, vol. 15, pp. 97-117.
29. Kolb M., Botet R., and Jullien R. Scaling Kinetically Growing Clusters. Physical Review Letters, 1983, vol. 51, no. 13, pp. 1123. DOI: https://doi.org/10.1103/PhysRevLett.51.1123.
30. Weitz D.A., Huang J.S., Lin M.Y., and Sung J. Limits of the Fractal Dimension for Irreversibl KineticAggregation of Gold Colloids. Physical Review Letters, 1985, vol. 54, no. 13, pp. 1416-1419. DOI: https://doi.org/10.1103/ PhysRevLett.54.1416.
31. Gonzalez A.E. Universality of Colloid Aggregation in the Reaction Limit-the Computer-Simulations. Physical Review Letters, 1993, vol. 71, no. 14, pp. 2248-2251. DOI: https://doi.org/10.1103/PhysRevLett.71.2248.
32. Fry D. Aggregation in Dense Particulate System. Ph. D. Thesis. Kansas State Universality, 2003.
33. Suterland D.N. and Goodarzn-Nia I. Floc Simulations - Effect of Collision Sequence. Chemical Engineering Science, 1971, vol. 26, no. 12, pp. 2071-2085. DOI:https://doi.org/10.1016/0009-2509(71)80045-3.
34. Meakin P. and Donn B. Aerodynamic Properties of Fractal Grains - Implications for the Primordial Solar Nebula. The Astrophysical Journal, 1988, vol. 329, pp. 39.
35. Hasmy A. Aerogelation Process Simulation by Cluster- Cluster Aggregation Algorithm. Journal of Sol-Gel Science and Technology, 1999, vol. 15, pp. 137-146.
36. Meacin P. Computer-Simulations of the Cluster- Cluster Aggregation using Linear Trajectories-Results from 3-Dimensional Simulations and a Comparison with Aggregates Formed using Brownian Trajectories. J. of Colloid and Interface Science, 1984, vol. 102, pp. 505-512.
37. Mandelbrot B.B. The Fractal Geometry of Nature. US: W. H. Freeman and Co Publ., 1982. 480 p. (Russ. ed.: Mandelbrot B.B. Fraktal'naya geometriya prirody. Moscow: Institute of Computer Researches Publ., 2002. 656 p.).
38. Babich O.O., Razumnikova I.S. and Kozlova O.V. Tekhnologii polucheniya biologicheski aktivnykh peptidov iz belkov moloka [Technologies of Receiving Bioactive Peptides from Proteins of Milk]. Kemerovo: Kuzbassvuzizdat Publ., 2011. 119 p.
39. Wheyvolution. Proceedings of the 5th International Whey Conference. Paris, France, 2008. 51 p.
40. Smol'nikov N. Organization of Effective Conversion of Serum. Milk Processing, 2011, no. 8, pp. 16. (In Russian).
41. Tikhomirova N.A. Nauchnye i prakticheskie osnovy polucheniya iz molochnogo syr'ya biologicheski aktivnogo veshchestva angiogenina. Diss. dokt. tekhn. nauk [Scientific and Practical Bases of Receiving the Biologically Active Agent Angiogenin from Raw Milk. Dr. eng. sci. diss.]. Moscow, 2000. 320 p.
42. Tikhomirova N.A. Nauchnye i prakticheskie osnovy polucheniya iz molochnogo syr'ya biologicheski aktivnogo veshchestva angiogenina [Scientific and Practical Fundamentals of Receiving the Biologically Active Agent Angiogenin from Raw Milk]. Мoscow: Pishchevaya promyshlennost' Publ., 1999. 137 p.
43. Gorbatova K.K. Fiziko-khimicheskie i biokhimicheskie osnovy proizvodstva molochnykh produktov [Physico-Chemical and Biochemical Fundamentals of Production of Dairy Products]. Moscow: GIORD Publ., 2003. 352 p.
44. Lafishev A.F. Razrabotka tekhnologii belkovo-zhirovogo produkta na osnove tsel'nogo moloka i neseparirovannoy podsyrnoy syvorotki. Diss. kand. tekhn. nauk [Development of Technology of Protein and Fat Product on the Basis of Whole Milk and Unseparated Subcheese Serum. Cand. eng. sci. diss.]. Stavropol, 2003. 140 p.
45. Onopriyko V.A. Issledovanie i sovershenstvovanie tekhnologii kombinirovannykh syrov na osnove sistemnogo analiza. Avtoref. diss. kand. tekhn. nauk [Research and Improvement of Technology of Combined Cheeses on the Basis of System Analysis. Cand. eng. sci. thesis]. Stavropol, 2002. 19 p.
46. Klepker V.M. Razrabotka tekhnologii tvorozhnykh izdeliy s bifidogennoy aktivnost'yu. Diss. kand. tekhn. nauk [Development of Technology of Cottage Cheese Products with Bifidogenic Activity. Cand. eng. sci. diss.]. Stavropol, 2005.
47. Dudnikova O.A. Razrabotka tekhnologii lipidno-belkovogo kontsentrata iz molochnogo syr'ya. Avtoref. diss. kand. tekhn. nauk [Development of Technology of Lipid and Protein Concentrate of Raw Milk. Cand. eng. sci. thesis]. Stavropol, 2011. 24 p.
48. Suyunchev O.A. Razrabotka resursosberegayushchikh tehnologiy myagkikh syrov i drugikh produktov iz korov'ego i koz'ego moloka. Diss. dokt. tekhn. nauk [Development of Resource-Saving Technologies of Soft Cheeses and Other Products of Cow and Goat Milk. Dr. eng. sci. diss.]. Stavropol, 2006. 330 p.
49. Zobkova Z.S., Zenina D.V., Fursova T.P., et al. Criteria of Assessment of Safety of the Milk Products with Transglutaminase. Dairy Industry, 2015, no. 3, pp. 48-51.
50. Smirnova I.А. Teoreticheskoe obosnovanie i issledovanie zakonomernostey formirovaniya syrov s termokislotnoy koagulyatsiey belkov moloka. Avtoref. diss. dokt. tekhn. nauk [Theoretical Justification and Research of Regularities of Formation of Cheeses with the Thermal Acid Coagulation of Milk Proteins. Dr. eng. sci. thesis]. Kemerovo, 2003. 40 p.
51. Trukhachev V.I., Molochnikov V.V., Orlova T.А., et al. Teoriya i praktika bezotkhodnoy pererabotki moloka v zamknutom tekhnologicheskom tsikle [Theory and Practice of Waste-Free Milk Processing in a Closed Technological Cycle]. Stavropol: AGRUS Publ., 2012. 360 p.
52. Khramtsov A.А. Teoreticheskoe i eksperimental'noe obosnovanie biomembrannoy tekhnologii molochnogo polisakharidnogo kontsentrata. Diss. dokt. tekhn. nauk [Theoretical and Experimental Justification of Biomembrane Technology of Dairy Polysaccharidic Concentrate. Dr. eng. sci. diss.]. Moscow, 1999. 405 p.
53. Orlova T.А. Tekhnologicheskie printsipy proizvodstva funktsional'nykh molochnykh produktov s primeneniem polisakharidov. Diss. dokt. tekhn. nauk [Technological Principles of Production of Functional Dairy Products Using Polysaccharides. Dr. eng. sci. diss.]. Stavropol: North Caucasian State Technical University Publ., 2010. 362 p.
54. Molochnikov V.V., Orlova T.А., and Anisimov S.V. Bezotkhodnaya pererabotka obezzhirennogo moloka na osnove bezmembrannogo osmosa [Non-Waste Processing of Non-Fat Milk on the Basis of Membraneless Osmosis]. Moscow: AgroNIITEIMMP Publ., 1986. 36 p.
55. Molochnikov V.V., Orlova T.А., Ostroukhova L.A., et al. Concentrate of the Natural Casein. Dairy Industry, 2008, no. 12, pp. 57-58. (In Russian).
56. Molochnikov V.V., Orlova T.А., and Suyunchev O.A. Processing of Dairy Raw Materials with the Use of Polysaccharides Using the Technology "Bio-Ton". Food Processing Industry, 1996, no. 5, pp. 34-35.
57. Kruglik V.I. Teoriya i praktika realizatsii tekhnologiy spetsializirovannykh produktov na osnove fermentativnykh gidrolizatov molochnykh belkov [Theory and Practice of Implementation of Technologies of Specialized Products on the Basis of Enzymatic Hydrolyzates of Milk Proteins]. Kemerovo-Moscow: Publishing Association "Russian Universities", 2007. 220 p.
58. Babich O.O. Biotekhnologiya L-fenilalanin-ammoniy-liazy [Biotechnology of L-phenylalanine-ammonium-lyase]. Novosibirsk: Nauka Publ., 2013. 199 p.
59. Prosekov A.Yu., Mudrikova O.V., and Babich O.O. Determination of cinnamic acid by capillary zone electrophoresis using ion-pair reagents. Journal of Analytical Chemistry, 2012, vol. 67, no. 5, pp. 474-477.
60. Babich O.O., Pokrovsky V.S., Anisimova N.Yu., et al. Recombinant L-phenylalanine ammonia lyase from Rhodosporidium toruloides as a potential anticancer agent. Biotechnology and Applied Biochemistry, 2013, vol. 60, no. 3, pp. 316-322.
61. Babich O.O., Dyshlyuk L.S., and Prosekov A.Yu. Effect of lyophilization conditions of recombinant L-phenylalanine-ammonia-lyase on enzyme properties. Middle-East Journal of Scientific Research, 2013, no. 15(10), pp. 1455-1459.
62. Patent US, no. 4734287, 1984.
63. Manylov S.V. Issledovanie vliyaniya denaturirovannykh syvorotochnykh belkov na svoystva nizkokaloriynykh molochno-belkovykh produktov. Avtoref. diss. kand. tekhn. nauk [Research of Influence of the Denatured Serumal Proteins on Properties of Low-Calorie Dairy and Proteinaceous Products. Cand. eng. sci. thesis]. Kemerovo, 2009. 22 p.
64. Podgornyy N.A. Poluchenie novoy pishchevoy kompozitsii i ee primenenie v tekhnologii sinbioticheskogo napitka. Diss. kand. tekhn. nauk [Receipt of a New Food Composition and its Application in the Technology of Synbiotic Drink. Cand. eng. sci. diss.]. Voronezh, 2013. 209 p.
65. Shtrigul' V.K. Issledovanie i razrabotka tekhnologii obezzhirennykh kislomolochnykh napitkov s primeneniem etapa mikropartikulyatsii belka. Avtoref. diss. kand. tekhn. nauk [Research and Development of Technology of Fat-Free Dairy Drinks with the Application of a Stage of Protein Microparticulation. Cand. eng. sci. thesis]. Kemerovo, 2013. 20 p.